Ginsenoside Rg5是一种从人参（Panax ginseng C. A. Mey.）根部分离和纯化的天然产物，具有抗炎作用。
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Ginsenoside Rg5 is a natural product isolated and purified from the roots of Panax ginseng C. A. Mey. showing anti-inflammatory effect.
Ginsenoside Rg5/人参皂甙 Rg5 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HEK293T cells
300 nM
24 hours
Increased interaction between MyoD and E2A
J Ginseng Res. 2023 Nov;47(6):726-734
conventional type 1 dendritic cells (cDC1s)
50 μM
2 hours
Enhanced efferocytosis of cDC1s from SLC7A11-WT mice
J Ginseng Res. 2023 Nov;47(6):784-794
bone marrow-derived dendritic cells (BMDCs)
50 μM
48 hours
Enhanced efferocytotic capability of BMDCs from db/db mice
J Ginseng Res. 2023 Nov;47(6):784-794
SK-N-SH cells
10 μM
48 hours
To evaluate the inhibitory effect of ginsenoside Rg5 on HSV-1-induced neuroinflammation, results showed that ginsenoside Rg5 significantly inhibited inflammatory cytokine expression.
J Ginseng Res. 2024 Jul;48(4):384-394
Vero cells
10 μM
48 hours
To evaluate the inhibitory effect of ginsenoside Rg5 on HSV-1 replication, results showed that ginsenoside Rg5 significantly inhibited HSV-1 replication.
Rg5 promoted HK-II binding to mitochondria and inhibited Drp1 activation via Akt activation, protecting mitochondrial morphological and functional integrity.
Cell Death Dis. 2017 Feb 23;8(2):e2625
Neonatal rat ventricular myocytes (NRVMs)
10 μM
2 hours
Rg5 prevented cellular acidification by combating fatty-acid oxidation and restoring PDH activity, thereby protecting mitochondrial HK-II binding and enhancing cardiomyocyte resistance to ischemic injury.
Cell Death Dis. 2017 Feb 23;8(2):e2625
Primary myoblast cells
300 nM
72 hours
Promoted primary myoblast differentiation, increased number of fused myoblasts
J Ginseng Res. 2023 Nov;47(6):726-734
C2C12 myoblasts
100，300 nM
48 hours
Promoted C2C12 myoblast differentiation, increased expression levels of MHC, troponin-T, and myogenin
J Ginseng Res. 2023 Nov;47(6):726-734
Caco-2 cells
8 μM
2 hours
To evaluate the effects of Rg5 on the function of ABCB1 transporter, results showed that Rg5 inhibited the function of ABCB1 transporter.
J Ginseng Res. 2020 Mar;44(2):247-257
A549/T cells
2, 4, 8 μM
48 hours
To evaluate the reversal effects of Rg5 on ABCB1-mediated multidrug resistance, results showed that Rg5 significantly increased the intracellular accumulation of ABCB1 substrates, thereby reversing drug resistance.
J Ginseng Res. 2020 Mar;44(2):247-257
A2780/T cells
2, 4, 8 μM
48 hours
To evaluate the reversal effects of Rg5 on ABCB1-mediated multidrug resistance, results showed that Rg5 significantly increased the intracellular accumulation of ABCB1 substrates, thereby reversing drug resistance.
J Ginseng Res. 2020 Mar;44(2):247-257
NCI-H292 human pulmonary mucoepidermoid carcinoma cells
0, 10, 50, 100 μg/mL
2 hours
To evaluate the effect of Rg5 on MUC5AC secretion and mRNA levels. Results showed that Rg5 significantly reduced MUC5AC secretion and mRNA levels without cytotoxicity.
J Ginseng Res. 2023 Jan;47(1):97-105
HT22 cells
0 mg/mL, 20 mg/mL, 40 mg/mL
4 h pretreatment followed by 6 h thermal stress
Investigate the protective effect of Rg5 against thermal stress-induced apoptosis in HT22 cells. Results showed Rg5 inhibited p21 expression and PARP cleavage, reduced NO production, and modulated HO-1/Nrf2 signaling and cognitive-associated proteins (e.g., BDNF, GSK3β).
J Ginseng Res. 2018 Apr;42(2):225-228
Ginsenoside Rg5/人参皂甙 Rg5 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
ICR mice
Isoproterenol-induced cardiac ischemia model
Oral
50 mg/kg
2 consecutive days
Rg5 promoted Akt translocation to mitochondria, increased mitochondrial HK-II binding, suppressed Drp1 recruitment, and reduced cell apoptosis, thereby protecting the heart from ischemic injury.
Cell Death Dis. 2017 Feb 23;8(2):e2625
Nude mice
A549/T cell xenograft model
Intraperitoneal injection
10, 30, 50 mg/kg
Every 3 days for a total of nine injections
To evaluate the reversal effects of Rg5 on ABCB1-mediated multidrug resistance in vivo, results showed that Rg5 significantly suppressed the growth of drug-resistant tumors.
J Ginseng Res. 2020 Mar;44(2):247-257
Mice
Db/db mice (diabetic model)
Oral gavage
20 or 80 mg/kg/day
Once daily for one week
Promoted skin wound healing in diabetic mice and reduced apoptotic cells in wound areas
J Ginseng Res. 2023 Nov;47(6):784-794
Zebrafish
Zebrafish model
Water bath exposure
2.54 mg/mL
24 hours
To study the metabolic pathways and metabolites of ginsenoside Rg5 in zebrafish
J Ginseng Res. 2017 Jan;41(1):78-84
C57BL/6 mice
Radiation-induced acute lung injury model
Intraperitoneal injection
30 mg/kg/day
For 3 consecutive days
Ginsenoside Rg5 pretreatment attenuated radiation-induced acute lung damage, preserved endothelial cell junction integrity, and maintained endothelial barrier function in vivo.
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