Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
生化试剂 囊泡 肿瘤 内分泌与代谢疾病
/
类固醇
NF-κB 帕金森与阿尔茨海默症 肿瘤干细胞 PPAR Signaling Pathway Wnt Signaling Pathway 细胞焦亡 胰腺癌 衰老 宫颈癌
/
NF-κB
胆汁酸
/ Phenethyl caffeate/咖啡酸苯乙酯

Phenethyl caffeate/咖啡酸苯乙酯 {[allProObj[0].p_purity_real_show]}

货号：A158279 同义名： 咖啡酸苯乙酯 / Caffeic acid phenethyl ester; CAPE

Phenethyl caffeate是一种天然产物，从肉桂（Cinnamomum cassia）树皮中分离纯化，是一种强效且特异性的 NF-κB 激活抑制剂，还表现出抗氧化、免疫调节和抗炎活性。

Phenethyl caffeate/咖啡酸苯乙酯 化学结构 CAS号：104594-70-9
Phenethyl caffeate/咖啡酸苯乙酯 化学结构
CAS号：104594-70-9
Phenethyl caffeate/咖啡酸苯乙酯 3D分子结构
CAS号：104594-70-9
Phenethyl caffeate/咖啡酸苯乙酯 化学结构 CAS号：104594-70-9
Phenethyl caffeate/咖啡酸苯乙酯 3D分子结构 CAS号：104594-70-9
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} 		{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Phenethyl caffeate/咖啡酸苯乙酯 纯度/质量文件 产品仅供科研

货号：A158279 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 NF-κB ↓ 其他靶点 纯度
Ammonium pyrrolidine-1-carbodithioate ✔ 98%
QNZ ++++

NF-κB, IC50: 11 nM

 		99%+
Sodium 4-Aminosalicylate Dihydrate ✔ 98%
Sodium Salicylate ✔ 95%
Parthenolide ✔ p53 97% HPLC
JSH-23 +

NF-κB, IC50: 7.1 μM

 		98%
Phenethyl caffeate ✔ 98%
Andrographolide ✔ 98+%
Curcumin ✔ HDAC,Nrf2 98%
SC75741 +++

NF-κB, EC50: 200 nM

 		99%+
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

 		p53 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Phenethyl caffeate/咖啡酸苯乙酯 生物活性

靶点

  • NF-κB
描述 NF-κB is a transcription factor with heterodimer or homodimer form of rel family proteins including RelA (p65), RelB, cRel, p50 and p52. Caffeic Acid Phenethyl Ester (CAPE) is an NF-κB inhibitor isolated from propolis. Treatment with CAPE at concentration ranging in 20-40μM for 2h could dose-dependently inhibit phosphorylation of IκBα and subsequently nuclear translocation of NF-κB (present as p65) induced by LPS in hepatic stellate cells. The increased nitrite production and the transcription and protein synthesis of MCP-1, IL-6 and iNOS induced by LPS could be significantly reduced by CAPE at concentration ranging in 5-40μM in a concentration-dependent manner in the same cells. Similarly, TNF-activated binding of NF-κB to DNA, phosphorylation of IκBα (within 30min) and p65 nuclear translocation could be observed in U937 cells pre-treated with 25μg/ml CAPE. Oral administration of 30mg/kg of CAPE daily for 4 weeks could improve the glucose sensitivity associated with the improvement in insulin-stimulated phosphorylation of the insulin receptor substrate-2 and an increase in Akt phosphorylation, promote amelioration in hepaticsteatosis, as well as reduced the induction of the inflammatory pathway, including JNK, NF-κB and COX-2 pathway, in high-fat-diet mice.

Phenethyl caffeate/咖啡酸苯乙酯 细胞实验

Cell Line
Concentration Treated Time Description References
HCT116 cells 10, 5, 2.5 mg/L 24 hours CAPE induced G0/G1 phase arrest and apoptosis in HCT116 cells, with apoptosis rates of 25.5±3.3%, 16.6±0.6%, 10.2±0.7%, respectively. World J Gastroenterol. 2005 Jul 14;11(26):4008-12
HCT116 cells 80, 40, 20, 10, 5, 2.5 mg/L 24, 48, 72, 96 hours CAPE inhibited HCT116 cell proliferation in a dose- and time-dependent manner, with IC50 values of 22.45, 12.07, 6.47, 5.36 mg/L, respectively. World J Gastroenterol. 2005 Jul 14;11(26):4008-12

Phenethyl caffeate/咖啡酸苯乙酯 动物研究

Dose Rat: 3 mg/kg, 6 mg/kg[3] (i.p.); 1 mg/kg - 20 mg/kg[4] (i.v.); 20 μg/kg/day[5] (p.o.) Pups: 40 mg/kg[6] (i.p.)
Administration i.p., i.v., p.o.
Pharmacokinetics
Animal Rats[7]
Dose 20 mg/kg
Administration i.v.
CLt 148.2 ± 70.4 ml/min/kg
T1/2 28.7 ± 9.1 min
B 1.071 ± 0.926 μg/ml
α 0.468 ± 0.038 min-1
Vz 5784 ± 2579 min/kg
A 53.6 ± 15.6 μg/ml
AUC∞ 160.5 ± 74.4 μg·min/ml
β 0.027 ± 0.011 min-1

Phenethyl caffeate/咖啡酸苯乙酯 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02744703 Matrix Metalloproteinase Inhib... 展开 >>itors Composite Resins 收起 << Not Applicable Completed - -

Phenethyl caffeate/咖啡酸苯乙酯 参考文献

[1]Banskota AH, Nagaoka T, et al. Antiproliferative activity of the Netherlands propolis and its active principles in cancer cell lines. J Ethnopharmacol. 2002 Apr;80(1):67-73.

[2]Natarajan K, Singh S, et al. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9090-5.

[3]Kumar M, Kaur D, et al. Caffeic Acid Phenethyl Ester (CAPE) Prevents Development of STZ-ICV Induced dementia in Rats. Pharmacogn Mag. 2017 Jan;13(Suppl 1):S10-S15.

[4]Iraz M, Fadillioglu E, et al. Role of vagal activity on bradicardic and hypotensive effects of caffeic acid phenethyl ester (CAPE). Cardiovasc Toxicol. 2005 Fall;5(4):391-6.

[5]Bozkurt Y, Bozkurt M, et al. Caffeic acid phenethyl ester protects kidneys against acetylsalicylic acid toxicity in rats. Ren Fail. 2012;34(9):1150-5.

[6]Wei X, Zhao L, et al. Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury. Brain. 2004 Dec;127(Pt 12):2629-35. Epub 2004 Oct 6.

[7]Wang X, Pang J, et al. Pharmacokinetics of caffeic acid phenethyl ester and its catechol-ring fluorinated derivative following intravenous administration to rats. Biopharm Drug Dispos. 2009 Jul;30(5):221-8.

Phenethyl caffeate/咖啡酸苯乙酯 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.17mL

7.03mL

3.52mL

Phenethyl caffeate/咖啡酸苯乙酯 技术信息

CAS号104594-70-9
分子式C17H16O4
分子量 284.31
SMILES Code O=C(OCCC1=CC=CC=C1)/C=C/C2=CC=C(O)C(O)=C2
MDL No. MFCD00866470
别名 咖啡酸苯乙酯 ;Caffeic acid phenethyl ester; CAPE; BAF-IN-C09; β-Phenylethyl Caffeate; 2-Phenylethyl Caffeate; Caffeic Acid phenylethyl ester; Phenylethyl Caffeate
运输蓝冰
InChI Key SWUARLUWKZWEBQ-VQHVLOKHSA-N
Pubchem ID 5281787
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C
溶解方案

DMSO: 105 mg/mL(369.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Caffeic acid phenethyl ester | 104594-70-9 | Apoptosis Inducer | NF-κB | Apoptosis | NF-κB | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Phenethyl caffeate/咖啡酸苯乙酯 纯度/质量文件 | Phenethyl caffeate/咖啡酸苯乙酯 亚型比较 | Phenethyl caffeate/咖啡酸苯乙酯 生物活性 | Phenethyl caffeate/咖啡酸苯乙酯 动物研究 | Phenethyl caffeate/咖啡酸苯乙酯 临床数据 | Phenethyl caffeate/咖啡酸苯乙酯 参考文献 | Phenethyl caffeate/咖啡酸苯乙酯 实验方案 | Phenethyl caffeate/咖啡酸苯乙酯 技术信息

AmBeed 相关网站 AmBeed.cn AmBeed.com
AmBeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    AmBeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 AmBeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z