Mefenamic Acid | 甲灭酸 | C.I. 473 | COX Inhibitor | AmBeed-信号通路专用抑制剂

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Mefenamic Acid/甲芬那酸 {[allProObj[0].p_purity_real_show]}

货号：A138400 同义名： 甲灭酸 / C.I. 473; CN-35355

Mefenamic Acid是一种非甾体抗炎药，为 hCOX-1 和 hCOX-2 的竞争性抑制剂 (IC50 = 40 nM 和 3 μM)，具有抗炎和镇痛作用，广泛用于炎症相关疾病研究。

Mefenamic Acid/甲芬那酸化学结构
CAS号：61-68-7

Mefenamic Acid/甲芬那酸 3D分子结构
CAS号：61-68-7

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Mefenamic Acid/甲芬那酸纯度/质量文件产品仅供科研

货号：A138400 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

环氧化酶亚型比较

产品名称	COX ↓ ↑	COX-1 ↓ ↑	COX-2 ↓ ↑	纯度
Piroxicam	✔			98%
Salicylic acid	✔			98%
Phenacetin	✔			98%
Etodolac	✔			99%
Flunixin meglumine	✔			98%
Ibuprofen L-lysine	✔			98%
Nabumetone	✔			98%
Acemetacin	✔			98%
Diflunisal	✔			98%
Pranoprofen	✔			98%
Ampiroxicam	✔			98%
Meloxicam	✔			98%
Sulindac	✔			98%
Ketoprofen		✔		98%
Mefenamic Acid		✔		95%
Bromfenac sodium		✔		98%
Oxaprozin		✔		99%
Aspirin		✔		99%
Nepafenac		✔		98%
Zaltoprofen		✔		99%
Salicin		✔		98%
Suprofen		✔		99%+
Xanthohumol		✔		99%
Parecoxib			✔	98%
Tolfenamic Acid			+++ COX-2, IC50: 0.2 μM	98%
Etoricoxib			✔	99%
Niflumic Acid			✔	98%
Valdecoxib			++++ COX-2, IC50: 5 nM	99+%
Ibuprofen		+ COX-1, IC50: 13 μM	+ COX-2, IC50: 370 μM	98%
Indomethacin		++ COX1, IC50: 0.28 μM	+ COX-2, IC50: 14 μM	97%
Lornoxicam		++++ COX-1, IC50: 5 nM	++++ COX-2, IC50: 8 nM	98%
Meclofenamic acid sodium		++++ COX-1, IC50: 40 nM	+++ COX-2, IC50: 50 nM	99%
Asaraldehyde			✔	98%
Naproxen		+ COX-1, IC50: 8.7 μM	+ COX-2, IC50: 5.2 μM	98%
Diclofenac Sodium Salt		+++ COX-1, IC50: 60 nM	+++ COX-2, IC50: 200 nM	98%
NS-398			++ COX-2, IC50: 3.8 μM	95%
Amfenac Sodium Hydrate		++ COX-1, IC50: 250 nM	+++ COX-2, IC50: 150 nM	98%+
Nimesulide			+ COX-2, IC50: 26 μM	98%
Lumiracoxib		++ COX-1, Ki: 3 μM	+++ COX-2, Ki: 60 nM	98%
Rutaecarpine			✔	95%
Celecoxib			++++ COX-2, IC50: 40 nM	98%
Carprofen			++++ canine COX2, IC50: 30 nM	98%
Ketorolac		++ COX-1 (human), IC50: 1.23 μM	++ COX-2 (human), IC50: 3.50 μM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Mefenamic Acid/甲芬那酸生物活性

靶点

COX-1

描述

Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively^[2]. Mefenamic acid exerted cytotoxic effects on KB, Saos-2, and 1321N cells, where the viability was approximately 75%. U-87MG cells were resistant to mefenamic acid^[3]. Moreover, the memory enhancing activity of mefenamic acid might be due to activation of cholinergic transmission that has protected neuroinflammatory and neurodegenerative conditions caused by alcohol^[4]. Mefenamic acid had anti-inflammatory effects but did not reduce the progression of OA (osteoarthritis) lesions, thereby indicating that it is only effective for symptomatic control of OA^[5].

Mefenamic Acid/甲芬那酸细胞实验

Cell Line Pig urethral smooth muscle cells	Concentration	Treated Time	Description	References
Pig urethral smooth muscle cells	300 µM	5 min	To investigate the effects of mefenamic acid on voltage-dependent Ba2+ inward currents, the results showed that mefenamic acid increased voltage-dependent Ba2+ inward currents through the activation of L-type Ca2+ channels.	Br J Pharmacol. 2005 Apr;144(7):919-25.

Mefenamic Acid/甲芬那酸动物实验

Species Mouse	Animal Model Air pouch inflammation model	Administration	Dosage	Frequency	Description	References
Mouse	Air pouch inflammation model	Intraperitoneal injection	50 mg/kg	Single dose	Inhibited NLRP3 inflammasome-dependent IL-1β release	Nat Commun. 2016 Aug 11;7:12504

Mefenamic Acid/甲芬那酸临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02580344	Contraception	Phase 2	Completed	-	Egypt ... 展开 >> Assiut university Assiut, Egypt, 71111 收起 <<
NCT02968823	Pain, Postoperative ... 展开 >> Surgery, Oral 收起 <<	Not Applicable	Recruiting	December 2019	Austria ... 展开 >> MUVienna Recruiting Vienna, Austria Contact: Olga Plattner olga.plattner@meduniwien.ac.at 收起 <<
NCT02943655	Improve Quality of Life ... 展开 >> Heavy Menstrual Bleeding 收起 <<	Phase 3	Recruiting	February 2019	Egypt ... 展开 >> Ahmed Abbas Recruiting Assiut, Cairo, Egypt, 002 Contact: ahmed abbas bmr90@hotmail.com 收起 <<

Mefenamic Acid/甲芬那酸参考文献

[1]Pringsheim T, Davenport WJ, et al. Acute treatment and prevention of menstrually related migraine headache: evidence-based review. Neurology. 2008 Apr 22;70(17):1555-63.

[2]Gierse JK, Hauser SD, Creely DP, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995;305 ( Pt 2)(Pt 2):479-484

[3]Hashemipour MA, Mehrabizadeh Honarmand H, Falsafi F, Tahmasebi Arashlo M, Rajabalian S, Gandjalikhan Nassab SA. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016;17(3):219-225

[4]Rajesh V, Mridhulmohan M, Jayaseelan S, Sivakumar P, Ganesan V. Mefenamic Acid Attenuates Chronic Alcohol Induced Cognitive Impairment in Zebrafish: Possible Role of Cholinergic Pathway. Neurochem Res. 2018;43(7):1392-1404

[5]Aguiar GC, Queiroz-Junior CM, Sitta GL, et al. Mefenamic acid decreases inflammation but not joint lesions in experimental osteoarthritis. Int J Exp Pathol. 2016;97(6):438-446

Mefenamic Acid/甲芬那酸实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.14mL

0.83mL

0.41mL

20.72mL

4.14mL

2.07mL

41.44mL

8.29mL

4.14mL

Mefenamic Acid/甲芬那酸技术信息

CAS号	61-68-7
分子式	C₁₅H₁₅NO₂
分子量	241.29
SMILES Code	C1=C(C(=CC=C1)C(O)=O)NC2=C(C(=CC=C2)C)C
MDL No.	MFCD00051721

别名	甲灭酸 ;C.I. 473; CN-35355; Apo Mefenamic; Antigen Brand of Mefenamic Acid; Acid, Mefenaminic; Acid, Mefenamic; Mefacit; Clonmel Brand of Mefenamic Acid; Coslan; Parkemed; Ponstel; NSC 94437; CI 473
运输	蓝冰
InChI Key	HYYBABOKPJLUIN-UHFFFAOYSA-N
Pubchem ID	4044

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, room temperature

溶解方案

细胞实验：

DMSO: 105 mg/mL(435.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02580344	Contraception	Phase 2	Completed	-	Egypt ... 展开 >> Assiut university Assiut, Egypt, 71111 收起 <<
NCT02968823	Pain, Postoperative ... 展开 >> Surgery, Oral 收起 <<	Not Applicable	Recruiting	December 2019	Austria ... 展开 >> MUVienna Recruiting Vienna, Austria Contact: Olga Plattner olga.plattner@meduniwien.ac.at 收起 <<
NCT02943655	Improve Quality of Life ... 展开 >> Heavy Menstrual Bleeding 收起 <<	Phase 3	Recruiting	February 2019	Egypt ... 展开 >> Ahmed Abbas Recruiting Assiut, Cairo, Egypt, 002 Contact: ahmed abbas bmr90@hotmail.com 收起 <<
NCT03383133	Metabolic Side Effects of Drug... 展开 >>s 收起 <<	Early Phase 1	Not yet recruiting	April 2018	-
NCT02417337	Pain Postoper... 展开 >>ative Pain Irreversible Pulpitis 收起 <<	Phase 2	Completed	-	Sudan ... 展开 >> University of Khartoum, Faculty of Dentistry, Khartoum, Sudan, 111-11 收起 <<
NCT01598012	Primary Dysmenorrhea	Phase 4	Completed	-	Thailand ... 展开 >> Gynecologic Endocrinology Unit, Department of Obstetric and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand, 10700 收起 <<
NCT01942122	Endometrioma ... 展开 >>Visual Analogue Pain Scale: Moderate or Severe Pain 收起 <<	Phase 2 Phase 3	Recruiting	February 2019	Indonesia ... 展开 >> Yasmin Clinic, Dr. Cipto Mangunkusumo Hospital (Kencana) Recruiting Jakarta Pusat, Jakarta, Indonesia, 10430 Contact: Kanadi Sumapraja, SpOG(K), MD +6221 3928720 kanadisuma@yahoo.com Contact: Budi Wiweko, SpOG(K), MD +6221 39831098 wiwekobudi@yahoo.co.id Sub-Investigator: R. Muharam, SpOG(K), MD Sub-Investigator: Andon Hestiantoro, SpOG(K), MD Sub-Investigator: Budi Wiweko, SpOG(K), MD Sub-Investigator: Herbert Situmorang, SpOG(K), MD Sub-Investigator: Gita Pratama, SpOG(K), MD Sub-Investigator: Achmad K Harzif, SpOG, MD Sub-Investigator: Mila Maidarti, SpOG, MD Sub-Investigator: Vita Silvana, SpOG, MD Department of Obstetrics and Gynecology, RSUP Persahabatan Recruiting Jakarta Pusat, Jakarta, Indonesia Contact: Botefilia, SpOG (K), MD +62214891708 botefilia@yahoo.com Principal Investigator: Botefilia, SpOG (K), MD Sub-Investigator: Zakia, SpOG, MD Sub-Investigator: Devi Marischa, SpOG, MD Department of Obstetrics and Gynecology RSUP Fatmawati Recruiting Jakarta, Indonesia Contact: Agus S As'adi, SpOG (K), MD +62217501524 agus_surur_asadi@yahoo.com Principal Investigator: Agus S As'adi, SpOG (K), MD Sub-Investigator: Luky S Syahbana, SpOG (K), MD Sub-Investigator: Malvin, SpOG (K), MD 收起 <<
NCT01295294	Uterine Hemorrhage	Phase 4	Completed	-	Denmark ... 展开 >> København NV, Denmark, DK-2400 Odense C, Denmark, DK-5000 Skive, Denmark, DK-7800 Søborg, Denmark, DK-2860 Ålborg, Denmark, DK-9000 Århus C, Denmark, DK-8000 Ireland Mallow, Cork, Ireland Blackrock, Dublin, Ireland Cork, Ireland Norway Elverum, Norway, 2403 Haugesund, Norway, 5507 Trondheim, Norway, 7012 收起 <<
NCT02183025	Dysmenorrhea	Phase 2	Completed	-	-
NCT03070678	Diabetes Mellitus	Phase 1	Completed	-	France ... 展开 >> Investigational site 250001 Gières, France 收起 <<
NCT03323671	Primary Dysmenorrhea	Phase 2 Phase 3	Completed	-	Egypt ... 展开 >> Mansoura University Mansourah, Egypt, 35516 收起 <<
NCT01060696	Infertility	Not Applicable	Unknown	May 2010	Thailand ... 展开 >> Siriraj hospital Mahidol university Bangkok, Thailand, 10700 收起 <<

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Mefenamic Acid/甲芬那酸纯度/质量文件产品仅供科研

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Mefenamic Acid/甲芬那酸生物活性

Mefenamic Acid/甲芬那酸细胞实验

Mefenamic Acid/甲芬那酸动物实验

Mefenamic Acid/甲芬那酸临床研究

Mefenamic Acid/甲芬那酸参考文献

Mefenamic Acid/甲芬那酸实验方案

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Mefenamic Acid/甲芬那酸纯度/质量文件产品仅供科研

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Mefenamic Acid/甲芬那酸临床研究

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Mefenamic Acid/甲芬那酸实验方案

Mefenamic Acid/甲芬那酸技术信息