Meclofenamate Sodium (MS) is an nonsteroidal anti-inflammatory drugs (NSAIDs) used to reduce pain. Addition of exogenous proteasome to MS treated cells improved cell viability[2]. Single 100- and 200-mg doses of meclofenamate sodium are as safe as, and significantly more effective than, codeine 60 mg or placebo for episiotomy pain[3]. In the majority of patients (headache and craniofacial pain), the meclofenamate sodium period scored lowest or second-lowest after the follow-up period in mean pain intensity[4]. Meclofenamate sodium in the dose administered was equally effective in relieving pain and inflammation and restoring restricted function in patients with acute gout as indometacin when used in the generally recommended dose for this indication. Meclofenamate sodium, even at these high dosage levels, was better tolerated than indometacin[5]. Similar improvement in mobility of the vertebral column and spondylitic pain could be achieved with meclofenamate sodium and indometacin in patients with ankylosing spondylitis. Meclofenamate sodium offers an effective and safe alternative to indometacin in the treatment of patients with ankylosing spondylitis[6].
Meclofenamic acid sodium/甲氯芬那酸 钠盐 细胞实验
Cell Line
Concentration
Treated Time
Description
References
N87
0 μM, 10 μM, 20 μM, 30 μM, 40 μM, 50 Μm
To evaluate the effect of Meclofenamic acid on the proliferation of N87 cells, results showed that Meclofenamic acid inhibited N87 cell growth in a dose-dependent manner.
J Exp Clin Cancer Res. 2025 Jan 7;44(1):8.
HGC27
0 μM, 10 μM, 20 μM, 30 μM, 40 μM, 50 μM
To evaluate the effect of Meclofenamic acid on the proliferation of HGC27 cells, results showed that Meclofenamic acid inhibited HGC27 cell growth in a dose-dependent manner.
J Exp Clin Cancer Res. 2025 Jan 7;44(1):8.
HeLa cells
80 μM and 120 μM
24 h
To investigate the effect of MA2 on the level of m6A modification in HeLa cells, the results showed that MA2 significantly increased the level of m6A modification.
Nucleic Acids Res. 2015 Jan;43(1):373-84.
Mouse aortic smooth muscle cells
20 µM
Meclofenamic acid (20 µM) relaxed aortic segments precontracted with phenylephrine, and this relaxation was reversed by the Kv7 channel blocker XE991.
Br J Pharmacol. 2007 Jul;151(6):758-70.
GC-1 spg cells
40, 80, 120 μM
48 h
MA2 significantly increased the cellular m6A level and down-regulated the expression of CDK1, CDK2, CDK6 and CdC25a, resulting in arrest of G1/S transition and decrease of cell proliferation.
J Anim Sci Biotechnol. 2019 Jul 11;10:63.
bladder smooth muscle cells (SMC)
1 µM
MFA significantly reduced contraction amplitude, AUC, and baseline tone in bladder strips
Br J Pharmacol. 2013 Jul;169(6):1290-304.
HPC cells
50 mM
Treatment with MA2 significantly upregulated RNF183 protein levels, indicating that MA2 reversed the high glucose-induced downregulation of RNF183 expression by inhibiting m6A demethylase activity.
Cells. 2025 Mar 1;14(5):365.
Meclofenamic acid sodium/甲氯芬那酸 钠盐 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Hemorrhage-induced thalamic pain model
Intraperitoneal injection
1, 5, 10 mg/kg
Once daily for five days
MA significantly attenuated the Coll IV microinjection-induced TLR4 upregulation and contralateral mechanical allodynia, heat hyperalgesia, and cold hyperalgesia.
Stroke. 2021 Jul;52(7):2393-2403
Fetal lambs
Fetal lambs
Intravenous or intracerebral
0.8-10 mg/kg or 0.6-2.6 mg/kg
Not specified
Meclofenamate induced prolonged fetal breathing with a significant increase in breath amplitude, without altering blood gas values, heart rate, blood pressure, electrocortical activity, or eye movements.
United States, Florida
... 展开 >>
Baptist Health South Florida
Miami, Florida, United States, 33143
United States, New Jersey
Memoral Sloan Kettering Cancer Center
Basking Ridge, New Jersey, United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States, 07748
United States, New York
Memorial Sloan Kettering Cancer Center at Commack
Commack, New York, United States, 11725
Memorial Sloan Kettering Westchester
Harrison, New York, United States, 10604
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
United States, Pennsylvania
Lehigh Valley Health Network
Allentown, Pennsylvania, United States, 18103 收起 <<
United States, Florida
... 展开 >>
Baptist Health South Florida
Miami, Florida, United States, 33143
United States, New Jersey
Memoral Sloan Kettering Cancer Center
Basking Ridge, New Jersey, United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States, 07748
United States, New York
Memorial Sloan Kettering Cancer Center at Commack
Commack, New York, United States, 11725
Memorial Sloan Kettering Westchester
Harrison, New York, United States, 10604
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
United States, Pennsylvania
Lehigh Valley Health Network
Allentown, Pennsylvania, United States, 18103 收起 <<
搜索
