Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. In the animal model, both ketorolac 0.4% and bromfenac 0.09% demonstrated maximal anti-inflammatory activity in treated eyes[3]. Ketorolac (4 mg/kg/day, p.o.) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats[4]. Ketorolac (60 μg/10 μL) reduces the histological changes such as ischemic cell death, including cytoplasmic eosinophilia with disintegration of cytoarchitecture and nuclear pyknosis in rats. Intrathecal pretreatment with 60 microg of ketorolac significantly reduced neuronal death and improved hindlimb motor function, and the long-term survival was similar to that in the control group[5].
Ketorolac/酮咯酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
C26 or CHX207 tumor model
Oral
2 mg/kg
Daily until study endpoint
R-ketorolac (RK) ameliorated cancer-associated cachexia, prolonged survival of tumour-bearing mice, reduced loss, and improved muscle and adipose tissue loss.
Ketorolac was used for post-operative analgesia, and its effect on tumor growth was not mentioned.
Cells. 2024 Jun 19;13(12):1061
Mice
LSL-KrasG12D/+;Trp53f/f;Pdx1-Cre mouse model
Intraperitoneal injection
2 mg/kg
Single injection
Ketorolac was used for post-surgical analgesia, and the experimental results did not mention specific effects.
Cell Rep. 2019 Oct 29;29(5):1287-1298.e6
Mice
Pancreatic cancer model
Intraperitoneal injection
2 mg/kg
Single dose
Postoperative pain relief
J Clin Invest. 2019 May 21;129(8):3264-3276
Mice
Injury-induced peripheral inflammation model
Subcutaneous injection
30 mg/kg
Single injection, measured 1 hour later
To evaluate the anti-inflammatory effect of Ketorolac on CFA-induced inflammation, results showed that food deprivation had a larger anti-inflammatory effect than Ketorolac
Cell Rep. 2023 Nov 28;42(11):113338
Mice
C57BL/6NHsd mice
Subcutaneous injection
5 mg/kg
Immediately after surgery and 24 hours later
Provide postoperative analgesia
Neuropharmacology. 2022 Sep 1;215:109168
Mice
Young and adult mice
Intraperitoneal injection
1 mg/kg
30 minutes before each anesthesia, for three days
Ketorolac ameliorated the sevoflurane anesthesia-induced cognitive impairment
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