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/ Pranoprofen/普拉洛芬

Pranoprofen/普拉洛芬 {[allProObj[0].p_purity_real_show]}

货号：A138748 同义名： Y 8004; Pyranoprofen

Pranoprofen是一种非类固醇的 COX 抑制剂，具有抗炎作用，主要用于眼科疾病的研究。

Pranoprofen/普拉洛芬 化学结构 CAS号：52549-17-4
Pranoprofen/普拉洛芬 化学结构
CAS号：52549-17-4
Pranoprofen/普拉洛芬 3D分子结构
CAS号：52549-17-4
Pranoprofen/普拉洛芬 化学结构 CAS号：52549-17-4
Pranoprofen/普拉洛芬 3D分子结构 CAS号：52549-17-4
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Pranoprofen/普拉洛芬 纯度/质量文件 产品仅供科研

货号：A138748 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
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更多 >
产品名称 COX ↓ COX-1 ↓ COX-2 ↓ 其他靶点 纯度
Piroxicam ✔ 98%
Salicylic acid ✔ 98%
Phenacetin ✔ 98%
Etodolac ✔ 99%
Flunixin meglumine ✔ 98%
Ibuprofen L-lysine ✔ 98%
Nabumetone ✔ 98%
Acemetacin ✔ 98%
Diflunisal ✔ 98%
Pranoprofen ✔ 98%
Ampiroxicam ✔ 98%
Meloxicam ✔ 98%
Sulindac ✔ 98%
Ketoprofen ✔ 98%
Mefenamic Acid ✔ 95%
Bromfenac sodium ✔ 98%
Oxaprozin ✔ 99%
Aspirin ✔ 99%
Nepafenac ✔ 98%
Zaltoprofen ✔ 99%
Salicin ✔ 98%
Suprofen ✔ 99%+
Xanthohumol ✔ 99%
Parecoxib ✔ 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

 		98%
Etoricoxib ✔ 99%
Niflumic Acid ✔ 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

 		99+%
Ibuprofen +

COX-1, IC50: 13 μM

 		+

COX-2, IC50: 370 μM

 		98%
Indomethacin ++

COX1, IC50: 0.28 μM

 		+

COX-2, IC50: 14 μM

 		97%
Lornoxicam ++++

COX-1, IC50: 5 nM

 		++++

COX-2, IC50: 8 nM

 		98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

 		+++

COX-2, IC50: 50 nM

 		99%
Asaraldehyde ✔ 98%
Naproxen +

COX-1, IC50: 8.7 μM

 		+

COX-2, IC50: 5.2 μM

 		98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

 		+++

COX-2, IC50: 200 nM

 		98%
NS-398 ++

COX-2, IC50: 3.8 μM

 		95%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

 		+++

COX-2, IC50: 150 nM

 		98%+
Nimesulide +

COX-2, IC50: 26 μM

 		98%
Lumiracoxib ++

COX-1, Ki: 3 μM

 		+++

COX-2, Ki: 60 nM

 		98%
Rutaecarpine ✔ 95%
Celecoxib ++++

COX-2, IC50: 40 nM

 		98%
Carprofen ++++

canine COX2, IC50: 30 nM

 		98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

 		++

COX-2 (human), IC50: 3.50 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Pranoprofen/普拉洛芬 生物活性

靶点

  • COX
描述 Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology. Pranoprofen 0.1% was found to be as effective as diclofenac sodium 0.1% in reducing inflammation and pain after strabismus surgery. Pranoprofen could be used as a safe and effective anti-inflammatory alternative for the treatment of inflammation following strabismus surgery[3]. Pranoprofen has efficacy equivalent to a moderate-potency corticosteroid with a better safety profile. It should be considered for the treatment of chronic conjunctivitis of presumed nonbacterial origin[4]. Pranoprofen inhibited ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. Moreover, pranoprofen inhibited ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor[5].

Pranoprofen/普拉洛芬 细胞实验

Cell Line
Concentration Treated Time Description References
THP-1 cells 5 µM 24 hours Pranoprofen enhanced Dicer expression and decreased H2O2-induced IL-6 expression Theranostics. 2020 Apr 27;10(13):5749-5762.
CCD-18Co cells 5 µM 24 hours Pranoprofen enhanced Dicer expression and decreased H2O2-induced IL-6 expression Theranostics. 2020 Apr 27;10(13):5749-5762.
FHC cells 5 µM 24 hours Pranoprofen enhanced Dicer expression and decreased H2O2-induced IL-6 expression Theranostics. 2020 Apr 27;10(13):5749-5762.

Pranoprofen/普拉洛芬 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c mice BAC-induced dry eye model Intraconjunctival injection 0.1% Twice daily for 14 days To evaluate the therapeutic effect of Pranoprofen in dry eye models, results showed that Pranoprofen improved dry eye symptoms but was less effective than miR-223-3p. Invest Ophthalmol Vis Sci. 2024 Oct 1;65(12):1
C57BL/6 mice DSS-induced acute colitis and AOM/DSS-induced chronic colitis-associated tumor model Oral administration in drinking water 16 mg/kg Continuous administration Pranoprofen alleviated colitis and prevented colitis-associated tumorigenesis by upregulating Dicer expression Theranostics. 2020 Apr 27;10(13):5749-5762.

Pranoprofen/普拉洛芬 参考文献

[1]Li YH, Wen Q, Fan TJ, et al. Dose dependent cytotoxicity of pranoprofen in cultured human corneal endothelial cells by inducing apoptosis. Drug Chem Toxicol. 2015 Jan;38(1):16-21.

[2]Hosoi T, Sasaki M, et al. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells. Neurochem Int. 2009 Jan;54(1):1-6.

[3]Akyol-Salman I, Leçe-Sertöz D, Baykal O. Topical pranoprofen 0.1% is as effective anti-inflammatory and analgesic agent as diclofenac sodium 0.1% after strabismus surgery. J Ocul Pharmacol Ther. 2007;23(3):280-283

[4]Notivol R, Martínez M, Bergamini MV. Treatment of chronic nonbacterial conjunctivitis with a cyclo-oxygenase inhibitor or a corticosteroid. Pranoprofen Study Group. Am J Ophthalmol. 1994;117(5):651-656

[5]Hosoi T, Sasaki M, Baba S, Ozawa K. Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells. Neurochem Int. 2009;54(1):1-6

Pranoprofen/普拉洛芬 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.92mL

0.78mL

0.39mL

19.59mL

3.92mL

1.96mL

39.17mL

7.83mL

3.92mL

Pranoprofen/普拉洛芬 技术信息

CAS号52549-17-4
分子式C15H13NO3
分子量 255.27
SMILES Code CC(C1=CC(CC2=CC=CN=C2O3)=C3C=C1)C(O)=O
MDL No. MFCD00866111
别名 Y 8004; Pyranoprofen
运输蓝冰
InChI Key TVQZAMVBTVNYLA-UHFFFAOYSA-N
Pubchem ID 4888
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, store in freezer, under -20°C
溶解方案

DMSO: 105 mg/mL(411.33 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: Pranoprofen | 52549-17-4 | Apoptosis | Immunology/Inflammation | COX | Apoptosis | PGE synthase | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Pranoprofen/普拉洛芬 纯度/质量文件 | Pranoprofen/普拉洛芬 亚型比较 | Pranoprofen/普拉洛芬 生物活性 | Pranoprofen/普拉洛芬 参考文献 | Pranoprofen/普拉洛芬 实验方案 | Pranoprofen/普拉洛芬 技术信息

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