There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively[3]. Carprofen (10 µg/mL) shows cytoprotective effects in CCL (cranial) and CaCL (caudal) cells and decreases apoptosis of both cells. Carprofen (10 μg/mL) had the greatest cytoprotective effects for CCL and CaCL cells[4]. Carprofen acts in vivo on target tissues as COX-1-sparing drugs by sparing gastric PGE1 and PGE2 synthesis and production of TXB2 (thromboxane B2) by platelets[5]. The administration of maropitant alone and carprofen alone produced clinically significant sparing effects on the sevoflurane MAC-BAR (minimum alveolar concentration for blunting adrenergic response) in dogs. However, the combination of maropitant and carprofen did not produce any additive effect on the sevoflurane MAC-BAR reduction[6].
Carprofen/卡洛芬 细胞实验
Cell Line
Concentration
Treated Time
Description
References
T24 bladder cancer cells
40-100 μM
48 h
Induced p75NTR expression and inhibited cell survival
Mol Cancer Ther. 2008 Nov;7(11):3539-45
DU-145 prostate cancer cells
40-100 μM
48 h
Induced p75NTR expression and inhibited cell survival, inducing apoptosis via the p38 MAPK pathway
Mol Cancer Ther. 2008 Nov;7(11):3539-45
PC-3 prostate cancer cells
40-100 μM
48 h
Induced p75NTR expression and inhibited cell survival, inducing apoptosis via the p38 MAPK pathway
Mol Cancer Ther. 2008 Nov;7(11):3539-45
H4 neuroglioma cells
100 μM
overnight
Evaluate the effects of NSAIDs on Aβ42 secretion. Carprofen was the most potent compound, reducing Aβ42 by more than 90%.
Neurobiol Dis. 2010 Sep;39(3):449-56
Mycobacterium tuberculosis H37Rv
400 mg/L
4 h
Assess the effect of carprofen on gene expression in Mycobacterium tuberculosis
J Antimicrob Chemother. 2020 Nov 1;75(11):3194-3201
Mycobacterium smegmatis
62.5 mg/L
5 days
Evaluate the effect of carprofen on extracellular polymeric substances (EPS) in Mycobacterium smegmatis biofilms
J Antimicrob Chemother. 2020 Nov 1;75(11):3194-3201
Mycobacterium smegmatis
250 mg/L
5 days
Assess the inhibitory effect of carprofen on biofilm formation in Mycobacterium smegmatis
J Antimicrob Chemother. 2020 Nov 1;75(11):3194-3201
Mycobacterium smegmatis
62.5 mg/L
60 min
Evaluate the inhibitory effect of carprofen on efflux pumps in Mycobacterium smegmatis
J Antimicrob Chemother. 2020 Nov 1;75(11):3194-3201
Mycobacterium smegmatis
250 mg/L
24 h
Determine the minimum inhibitory concentration (MIC) of carprofen against Mycobacterium smegmatis
J Antimicrob Chemother. 2020 Nov 1;75(11):3194-3201
Carprofen/卡洛芬 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Transgenic mice
T7A6 mice
Food
10 mg/kg
Daily for 6 months
Evaluate the effect of Carprofen on Aβ42 levels in muscle. Carprofen had no significant effect on Aβ42 levels in muscle.
Neurobiol Dis. 2010 Sep;39(3):449-56
Mice
Inflammatory pain model (CFA-induced)
Intraperitoneal injection
5 mg/kg
Starting 1 hour prior to testing on days 2, 4 and 5 following saline/CFA injection.
To evaluate the effect of carprofen on voluntary gait changes in CFA-induced inflammatory pain model. Results showed that carprofen did not significantly reverse CFA-induced gait changes but completely attenuated CFA-induced heat and mechanical hypersensitivity.
Neuropharmacology. 2018 Mar 1;130:18-29
Rats
Excisional wound pain model
Subcutaneous injection
5 mg/kg
Single dose, evaluated at 1, 4, and 24 hours post-administration
To evaluate the effect of Carprofen on pain responses to thermal and mechanical stimulation in an excisional wound pain model. Results showed that Carprofen increased the withdrawal time to thermal stimulation at 1 and 4 hours post-administration but had no significant effect on mechanical withdrawal thresholds.
Korean J Pain. 2021 Apr 1;34(2):165-175
Canine
Healthy dogs
Oral
4.4 mg/kg
Single dose, observed for 6 hours
Evaluated the effect of Carprofen on growth factor and cytokine release, showing increased TGF-β1 concentrations at 6 h and significantly decreased IL-10 concentrations
Gels. 2024 Jun 12;10(6):396
Mice
STR/Ort mice spontaneous osteoarthritis model
Intraperitoneal injection
5 mg/kg
3 consecutive days
To evaluate the effect of carprofen on osteoarthritis-related pain relief. Results showed that carprofen treatment did not modify any gait measurements or treadmill noncompliance, suggesting that gait changes in STR/Ort mice were not due to pain.
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