There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Salicylic acid is an effective inhibitor of COX-2 activity at concentrations far below those required to inhibit NF-κB (20 mg/mL) activation. Salicylic acid inhibits prostaglandin E2 release when add together with interleukin 1β for 24 hr with an IC50 value of 5 μg/mL, an effect that is independent of NF-κB activation or COX-2 transcription or translation. Salicylic acid acutely (30 min) also causes a concentration-dependent inhibition of COX-2 activity measured in the presence of 0, 1, or 10 μM exogenous arachidonic acid. In contrast, when exogenous arachidonic acid is increased to 30 μM, salicylic acid is a very weak inhibitor of COX-2 activity with an IC50 of >100 μg/mL. Salicylic acid causes a concentration-dependent inhibition of COX-2 activity in the absence of added arachidonic acid or in the presence of 1 or 10 μM exogenous substrate with an apparent IC50 value of approximately 5 μg/mL. However, when the same experiments are performed using 30 μM arachidonic acid, salicylic acid is an ineffective inhibitor of COX-2 activity, with an apparent IC50 value of more than 100 μg/mL, and achieves a maximal inhibition of less than 50%[3]. Salicylic acid (SA) is a key plant hormone that mediates host responses against microbial pathogens[4].
Salicylic acid/水杨酸 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Arabidopsis pollen tubes
1-50 µM
3 hours
SA inhibited pollen tube elongation and germination in a concentration-dependent manner.
Mol Plant. 2016 Nov 7;9(11):1478-1491
Salicylic acid/水杨酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Arabidopsis thaliana
Arabidopsis seedlings
Medium treatment
100 µM
13 or 24 hours
Salicylic acid regulates PIN2 auxin transporter hyperclustering and root gravitropic growth via Remorin-dependent lipid nanodomain organisation in Arabidopsis thaliana.
New Phytol. 2021 Jan;229(2):963-978
Arabidopsis thaliana
Wild-type and transgenic plants
Culture medium treatment
20 µM
3 hours
SA inhibited pollen tube growth, while MeSA promoted pollen tube growth.
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