Parecoxib is a potent and selective COX-2 inhibitor. Parecoxib ameliorated postischemic mitochondria-mediated neuronal apoptosis induced by focal cerebral ischemia in rats and this neuroprotective potential is involved in phosphorylation of Akt and GSK-3β[3]. The prodrug Parecoxib as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB1-expressing HEK 293 cells and rat brain tissue. The analgesic effects of par and its metabolite val in Wistar rats may be at least partially mediated by a direct interaction with the CB1 receptors[4]. The COX-2 inhibitor parecoxib exerts its analgesic effect on surgical pain through the inhibition of neuronal ERK activation in the spinal cord. COX-2 inhibitor delivery prior to surgery has more potent analgesic effects[5]. Despite the absence of clinical adverse effects, parecoxib can impair anastomotic and abdominal wound healing on a histopathological level[6].
Parecoxib/帕瑞昔布 细胞实验
Cell Line
Concentration
Treated Time
Description
References
AC2F rat liver cells
5, 10, 20, 40, 80 µM
12 hours or 48 hours
To evaluate the cytotoxicity of parecoxib to Ac2F cells
Biomol Ther (Seoul). 2021 Sep 1;29(5):519-526
Human colorectal cancer DLD-1 cells
3 µM
48 hours
Parecoxib enhances resveratrol's ability to inhibit DLD-1 cell viability and increases apoptosis by inhibiting TXNDC5 and Akt phosphorylation.
Nutrients. 2024 Sep 6;16(17):3020
SW480 cells
3 µM
48 hours
To evaluate the inhibitory effect of parecoxib combined with 5-FU on the migration and invasion of SW480 cells. The results showed that the combination of parecoxib and 5-FU significantly inhibited cell migration and invasion.
Biomedicines. 2024 Jul 9;12(7):1526
DLD-1 cells
3 µM
48 hours
To evaluate the inhibitory effect of parecoxib combined with 5-FU on the migration and invasion of DLD-1 cells. The results showed that the combination of parecoxib and 5-FU significantly inhibited cell migration and invasion.
Biomedicines. 2024 Jul 9;12(7):1526
3T3-L1 murine preadipocytes
15, 30, 60 µM
8 days
To evaluate the effect of parecoxib on adipocyte differentiation
Biomol Ther (Seoul). 2021 Sep 1;29(5):519-526
Parecoxib/帕瑞昔布 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Sprague-Dawley rats
Pulmonary ischemia-reperfusion injury model
Intraperitoneal injection
10 mg/kg
Once daily for 5 consecutive days
Parecoxib sodium pretreatment alleviates pulmonary ischemia-reperfusion injury by inhibiting the ERK/NF-κB pathway and further activating the HIF-1α pathway.
Immun Inflamm Dis. 2022 Sep;10(9):e684
Sprague-Dawley rats
Ischemia reperfusion-induced intestinal injury model
Intraperitoneal injection
10 or 20 mg/kg
Once daily for 5 consecutive days
Parecoxib sodium pre-treatment significantly attenuated ischemia reperfusion-induced oxidative stress, inflammatory responses, and apoptosis, and increased the survival rate of rats.
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