Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
药物研究 酶学 肿瘤
/
小分子阳性药
酶制剂 免疫/炎症 酶抑制剂 其他抑制剂/激动剂 肿瘤发展和微环境演变
/
抗炎
环氧化酶 环氧合酶抑制剂 环氧合酶
/ Meloxicam/美洛昔康

Meloxicam/美洛昔康 {[allProObj[0].p_purity_real_show]}

货号：A186352 同义名： UH-AC 62XX

Meloxicam是一种非甾体抗炎药，选择性抑制 COX2（IC50 = 11.8 μM），对 COX1（IC50 = 143 μM）的抑制作用较弱，具有较低的胃肠毒性。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Meloxicam/美洛昔康 化学结构 CAS号：71125-38-7
Meloxicam/美洛昔康 化学结构
CAS号：71125-38-7
Meloxicam/美洛昔康 3D分子结构
CAS号：71125-38-7
Meloxicam/美洛昔康 化学结构 CAS号：71125-38-7
Meloxicam/美洛昔康 3D分子结构 CAS号：71125-38-7
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}

{[ getRatePriceInt(item.pr_rmb, 1,1) ]}

{[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} 		{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]} 现货 1周 咨询 - +
购物车0 收藏 询单

Meloxicam/美洛昔康 纯度/质量文件 产品仅供科研

货号：A186352 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 COX ↓ COX-1 ↓ COX-2 ↓ 其他靶点 纯度
Piroxicam ✔ 98%
Salicylic acid ✔ 98%
Phenacetin ✔ 98%
Etodolac ✔ 99%
Flunixin meglumine ✔ 98%
Ibuprofen L-lysine ✔ 98%
Nabumetone ✔ 98%
Acemetacin ✔ 98%
Diflunisal ✔ 98%
Pranoprofen ✔ 98%
Ampiroxicam ✔ 98%
Meloxicam ✔ 98%
Sulindac ✔ 98%
Ketoprofen ✔ 98%
Mefenamic Acid ✔ 95%
Bromfenac sodium ✔ 98%
Oxaprozin ✔ 99%
Aspirin ✔ 99%
Nepafenac ✔ 98%
Zaltoprofen ✔ 99%
Salicin ✔ 98%
Suprofen ✔ 99%+
Xanthohumol ✔ 99%
Parecoxib ✔ 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

 		98%
Etoricoxib ✔ 99%
Niflumic Acid ✔ 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

 		99+%
Ibuprofen +

COX-1, IC50: 13 μM

 		+

COX-2, IC50: 370 μM

 		98%
Indomethacin ++

COX1, IC50: 0.28 μM

 		+

COX-2, IC50: 14 μM

 		97%
Lornoxicam ++++

COX-1, IC50: 5 nM

 		++++

COX-2, IC50: 8 nM

 		98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

 		+++

COX-2, IC50: 50 nM

 		99%
Asaraldehyde ✔ 98%
Naproxen +

COX-1, IC50: 8.7 μM

 		+

COX-2, IC50: 5.2 μM

 		98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

 		+++

COX-2, IC50: 200 nM

 		98%
NS-398 ++

COX-2, IC50: 3.8 μM

 		95%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

 		+++

COX-2, IC50: 150 nM

 		98%+
Nimesulide +

COX-2, IC50: 26 μM

 		98%
Lumiracoxib ++

COX-1, Ki: 3 μM

 		+++

COX-2, Ki: 60 nM

 		98%
Rutaecarpine ✔ 95%
Celecoxib ++++

COX-2, IC50: 40 nM

 		98%
Carprofen ++++

canine COX2, IC50: 30 nM

 		98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

 		++

COX-2 (human), IC50: 3.50 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Meloxicam/美洛昔康 生物活性

靶点

  • COX
描述 Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively[3]. Meloxicam (0.25 µg/mL) decreases CF41.Mg cell migration and invasion, induces decrease in MMP-2 expression, and increases β-catenin phophorylation in CF41.Mg cells, but does not affect the CF41.Mg cell apoptosis. Meloxicam inhibits COX+ tumor cells, but shows no cytotoxicity on CF41.Mg or MDCK cells at 0.25-25 µg/mL. Furthermore, Meloxicam in combination with doxorubicin, has no synergistic effect on CF41.Mg cells[4]. Meloxicam (10 mg/kg) alone or in combination with rutin significantly decreases paw liking time on 1st day by 55% and 49% compared with the formalin-treated group, respectively, however the combination reduces time non-significantly on 3rd day in mice. Meloxicam alone or in combination with rutin also decreases relative liver weights, reduces MDA contents, induces liver SOD activities, hampers IL-1β content, and significantly reduces the number of positive caspase-3 immunoreactive cells in mice[5].

Meloxicam/美洛昔康 细胞实验

Cell Line
Concentration Treated Time Description References
U937 cells 500 µM 6 h Test the effect of Meloxicam on the DNA-sensing pathway in U937 cells, results showed that Meloxicam inhibited the DNA-sensing pathway Cell Biosci. 2023 Apr 29;13(1):76.
L929 cells 500 µM 6 h Test the effect of Meloxicam on the DNA-sensing pathway in L929 cells, results showed that Meloxicam inhibited the DNA-sensing pathway Cell Biosci. 2023 Apr 29;13(1):76.
L929 cells 1000 µM 24 h Test the cytotoxicity of Meloxicam on L929 cells, results showed that concentrations below 1000 µM are safe for the cells Cell Biosci. 2023 Apr 29;13(1):76.

Meloxicam/美洛昔康 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Mice Trex1–/– mouse model Intraperitoneal injection 5 mg/kg Once daily for 90 days Test the effect of Meloxicam on the Trex1–/– mouse model, results showed that Meloxicam significantly increased the survival rate of the mice Cell Biosci. 2023 Apr 29;13(1):76.
Wistar rats Osteoarthritis model Intra-articular injection 9.45 mg/kg Single injection, observed for 144 hours To evaluate the pharmacokinetics, tissue distribution, and pharmacodynamics of Meloxicam microspheres in vivo. The results showed that intra-articular injection of Meloxicam microspheres could prolong the drug action time and reduce side effects. Drug Deliv. 2022 Dec;29(1):3317-3327
Mice Alzheimer's disease model Intragastric gavage 5 mg/kg Once every 48 hours for 12 days To investigate the effects of Meloxicam on cognitive impairment in a mouse model of Alzheimer's disease, results showed that Meloxicam improved memory impairment in mice. Neural Regen Res. 2021 Apr;16(4):783-789
Rats Transient focal cerebral ischemia model Intravenous injection 1 mg/kg 1 and 24 hours after reperfusion To evaluate the neuroprotective effects of Meloxicam in a transient focal cerebral ischemia model. Results showed that Meloxicam maintained neuroprotective effects after 48 hours and 7 days of reperfusion, modulated glial scar reactivity, increased axonal sprouting, but decreased the formation of neuronal progenitor cells. Neural Regen Res. 2023 Sep;18(9):1961-1967
Dogs Ovariectomy model Subcutaneous and oral 0.2 mg/kg, 0.1 mg/kg Once before surgery and every 24 hours after surgery until the end of the experiment To evaluate the effect of Meloxicam on oxidative stress and serotonin levels during ovariectomy. Results showed a significant increase in oxidative stress and serotonin levels post-surgery, with a positive correlation between the two. Vet Q. 2024 Dec;44(1):1-8

Meloxicam/美洛昔康 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02191358 - Completed - United States, California ... 展开 >> Dr. Michael Dao Garden Grove, California, United States, 92844 United States, Colorado Kaiser Permanente Colorado Denver, Colorado, United States, 80011 United States, Kentucky Gill Heart Institute Lexington, Kentucky, United States, 40508 United States, Maryland IRC Clinics Towson, Maryland, United States, 21204 United States, Massachusetts Internal Medicine & Cardiology Associates Fall River, Massachusetts, United States, 02720 Prima CARE Fall River, Massachusetts, United States, 02720 United States, Virginia Carilion Clinic Christiansburg, Virginia, United States, 24073 收起 <<
NCT01638962 Osteoarthritis, Knee Not Applicable Completed - Denmark ... 展开 >> University of Southern Denmark Odense, Region Syddanmark, Denmark, 5230 收起 <<
NCT03549611 Kidney Calculi ... 展开 >> Pain, Postoperative 收起 << Phase 4 Not yet recruiting June 30, 2019 -

Meloxicam/美洛昔康 参考文献

[1]Tsubouchi Y, Mukai S, et al. Meloxicam inhibits the growth of non-small cell lung cancer. Anticancer Res. 2000 Sep-Oct;20(5A):2867-72.

[2]Busch U, Heinzel G, Narjes H. The effect of cholestyramine on the pharmacokinetics of meloxicam, a new non-steroidal anti-inflammatory drug (NSAID), in man. Eur J Clin Pharmacol. 1995;48(3-4):269-72.

[3]Lazer ES, Miao CK, Cywin CL, et al. Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity. J Med Chem. 1997;40(6):980-989

[4]Iturriaga MP, Paredes R, Arias JI, Torres CG. Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. Oncol Lett. 2017;14(2):2198-2206

[5]Fikry EM, Hasan WA, Mohamed EG. Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity. J Biochem Mol Toxicol. 2018;32(2):10.1002/jbt.22029

Meloxicam/美洛昔康 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.85mL

0.57mL

0.28mL

14.23mL

2.85mL

1.42mL

28.46mL

5.69mL

2.85mL

Meloxicam/美洛昔康 技术信息

CAS号71125-38-7
分子式C14H13N3O4S2
分子量 351.4
SMILES Code O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NC=C(C)S3
MDL No. MFCD00868752
别名 UH-AC 62XX
运输蓝冰
InChI Key ZRVUJXDFFKFLMG-UHFFFAOYSA-N
Pubchem ID 54677470
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, store in freezer, under -20°C
溶解方案

DMSO: 9 mg/mL(25.61 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二

Tags: Meloxicam/美洛昔康 |Meloxicam/美洛昔康 | UH-AC 62XX | 71125-38-7 | 抗炎 | 环氧化酶 | 环氧合酶抑制剂 | 环氧合酶 | Meloxicam/美洛昔康 纯度/质量文件 | Meloxicam/美洛昔康 亚型比较 | Meloxicam/美洛昔康 生物活性 | Meloxicam/美洛昔康 临床数据 | Meloxicam/美洛昔康 参考文献 | Meloxicam/美洛昔康 实验方案 | Meloxicam/美洛昔康 技术信息

AmBeed 相关网站 AmBeed.cn AmBeed.com
AmBeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    AmBeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 AmBeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z