Salicin | D-(−)-Salicin;Salicoside;D-(-)-Salicin;NSC 5751 | D(-)-水杨苷 | Plant Standard | COX

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Salicin/水杨苷 {[allProObj[0].p_purity_real_show]}

货号：A190057 同义名： D(-)-水杨苷 / Salicoside; D-(-)-Salicin

Salicin是一种非选择性的 COX-1 和 COX-2 抑制剂，是从白柳（Salix alba L.）的树皮中提取的苯酚 β-糖苷，具有抗炎作用。

Salicin/水杨苷化学结构
CAS号：138-52-3

Salicin/水杨苷 3D分子结构
CAS号：138-52-3

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Salicin/水杨苷纯度/质量文件产品仅供科研

货号：A190057 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

环氧化酶亚型比较

产品名称	COX ↓ ↑	COX-1 ↓ ↑	COX-2 ↓ ↑	纯度
Piroxicam	✔			98%
Salicylic acid	✔			98%
Phenacetin	✔			98%
Etodolac	✔			99%
Flunixin meglumine	✔			98%
Ibuprofen L-lysine	✔			98%
Nabumetone	✔			98%
Acemetacin	✔			98%
Diflunisal	✔			98%
Pranoprofen	✔			98%
Ampiroxicam	✔			98%
Meloxicam	✔			98%
Sulindac	✔			98%
Ketoprofen		✔		98%
Mefenamic Acid		✔		95%
Bromfenac sodium		✔		98%
Oxaprozin		✔		99%
Aspirin		✔		99%
Nepafenac		✔		98%
Zaltoprofen		✔		99%
Salicin		✔		98%
Suprofen		✔		99%+
Xanthohumol		✔		99%
Parecoxib			✔	98%
Tolfenamic Acid			+++ COX-2, IC50: 0.2 μM	98%
Etoricoxib			✔	99%
Niflumic Acid			✔	98%
Valdecoxib			++++ COX-2, IC50: 5 nM	99+%
Ibuprofen		+ COX-1, IC50: 13 μM	+ COX-2, IC50: 370 μM	98%
Indomethacin		++ COX1, IC50: 0.28 μM	+ COX-2, IC50: 14 μM	97%
Lornoxicam		++++ COX-1, IC50: 5 nM	++++ COX-2, IC50: 8 nM	98%
Meclofenamic acid sodium		++++ COX-1, IC50: 40 nM	+++ COX-2, IC50: 50 nM	99%
Asaraldehyde			✔	98%
Naproxen		+ COX-1, IC50: 8.7 μM	+ COX-2, IC50: 5.2 μM	98%
Diclofenac Sodium Salt		+++ COX-1, IC50: 60 nM	+++ COX-2, IC50: 200 nM	98%
NS-398			++ COX-2, IC50: 3.8 μM	95%
Amfenac Sodium Hydrate		++ COX-1, IC50: 250 nM	+++ COX-2, IC50: 150 nM	98%+
Nimesulide			+ COX-2, IC50: 26 μM	98%
Lumiracoxib		++ COX-1, Ki: 3 μM	+++ COX-2, Ki: 60 nM	98%
Rutaecarpine			✔	95%
Celecoxib			++++ COX-2, IC50: 40 nM	98%
Carprofen			++++ canine COX2, IC50: 30 nM	98%
Ketorolac		++ COX-1 (human), IC50: 1.23 μM	++ COX-2 (human), IC50: 3.50 μM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Salicin/水杨苷生物活性

靶点

COX-1

描述

Salicin is a natural COX inhibitor. At the cellular level, salicin attenuates IL-1β-induced mitochondrial injury as revealed by its preservation on mitochondrial membrane potential (MMP). Furthermore, salicin inhibits IL-1β-induced production of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1), vascular adhesion molecules such as intercellular cell adhesion molecule-1 (iCAM-1) and vascular cell adhesion molecule 1 (VCAM-1), and high-mobility group protein 1 (HMGB-1) ^[3]. Salicin significantly reduced cell viability, cytokines, and matrix metalloproteinases-1/-3 expression in IL-1β-induced RA-FLSs and inhibited ROS generation and p65 phosphorylation as compared with IL-1β-induced treatment. Moreover, salicin promoted Nrf2 nuclear translocation and HO-1 expression and reduced ROS production in IL-1β-induced RA-FLSs^[4].

Salicin/水杨苷细胞实验

Cell Line HEK293 cells Mouse gingival fibroblasts (MGFs) proximal colonic epithelial cells	Concentration	Treated Time	Description	References
HEK293 cells	10 mM		To validate whether Salicin can activate calcium signaling in HEK293 cells via Tas2r143, results showed that Salicin induced an increase in intracellular calcium.	Front Immunol. 2024 Mar 28;15:1374900.
Mouse gingival fibroblasts (MGFs)	10 mM	12 h	To investigate the inhibitory effect of Salicin on LPS-induced chemokine expression in MGFs, results showed that Salicin significantly down-regulated the expression of CXCL1, CXCL2, and CXCL5.	Front Immunol. 2024 Mar 28;15:1374900.
proximal colonic epithelial cells	5 mM	7 days	stimulate proximal colonic epithelial cells to release IL-25 and induce tuft cell proliferation	Front Immunol. 2023 Oct 25;14:1259521.

Salicin/水杨苷动物实验

Species Mongolian gerbils Mice Mice	Animal Model Transient forebrain ischemia model Ligature-induced periodontitis (LIP) mouse model Proximal colonic tuft cell model	Administration	Dosage	Frequency	Description	References
Mongolian gerbils	Transient forebrain ischemia model	Intraperitoneal injection	20 mg/kg	Once daily for 3 days	Salicin significantly protected hippocampal CA1 pyramidal neurons from ischemic injury by attenuating oxidative stress and activating the PI3K/Akt/GSK3β pathway.	Antioxidants (Basel). 2021 Apr 20;10(4):629
Mice	Ligature-induced periodontitis (LIP) mouse model	Topical application	100 mg/kg	Twice a day for 7 days	To investigate the effect of Salicin on periodontitis via taste transduction pathway, results showed that Salicin significantly inhibited periodontal bone loss and inflammatory factor expression, but these effects were abolished in Gnat3-/- mice.	Front Immunol. 2024 Mar 28;15:1374900.
Mice	Proximal colonic tuft cell model	Anal administration	5 mM	Twice a day for 7 days	Promote proximal colonic tuft cell proliferation by activating Tas2r receptors	Front Immunol. 2023 Oct 25;14:1259521.

Salicin/水杨苷临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01920841	Weight Loss	Not Applicable	Withdrawn(Study Design changed... 展开 >> and will be resubmitted as a new study) 收起 <<	-	United States, Louisiana ... 展开 >> Pennington Biomedical Research Center Baton Rouge, Louisiana, United States, 70808 收起 <<
NCT01956500	Joint Pain, Stiffness, Functio... 展开 >>n 收起 <<	Not Applicable	Completed	-	United States, North Carolina ... 展开 >> ASU Human Performance Laboratory, North Carolina Research Campus Kannapolis, North Carolina, United States, 28081 收起 <<

Salicin/水杨苷参考文献

[1]Akao T, Yoshino T, et al. Evaluation of salicin as an antipyretic prodrug that does not cause gastric injury. Planta Med. 2002 Aug;68(8):714-8.

[2]Maclagan T. The Treatment of Rheumatism by Salicin and Salicylic Acid. Br Med J. 1876 May 20;1(803):627.

[3]Song Y, Tian X, Wang X, Feng H. Vascular protection of salicin on IL-1β-induced endothelial inflammatory response and damages in retinal endothelial cells. Artif Cells Nanomed Biotechnol. 2019;47(1):1995-2002

[4]Zhai KF, Duan H, Khan GJ, et al. Salicin from Alangium chinense Ameliorates Rheumatoid Arthritis by Modulating the Nrf2-HO-1-ROS Pathways. J Agric Food Chem. 2018;66(24):6073-6082

Salicin/水杨苷实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.49mL

0.70mL

0.35mL

17.47mL

3.49mL

1.75mL

34.93mL

6.99mL

3.49mL

Salicin/水杨苷技术信息

CAS号	138-52-3
分子式	C₁₃H₁₈O₇
分子量	286.28
SMILES Code	O[C@@H]1[C@@H](CO)O[C@@H](OC2=CC=CC=C2CO)[C@H](O)[C@H]1O
MDL No.	MFCD00006590

别名	D(-)-水杨苷 ;Salicoside; D-(-)-Salicin; NSC 5751
运输	蓝冰
InChI Key	NGFMICBWJRZIBI-UJPOAAIJSA-N
Pubchem ID	439503

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, room temperature

溶解方案

细胞实验：

DMSO: 145 mg/mL(506.5 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 12 mg/mL(41.92 mM)，配合低频超声，并水浴加热至45℃助溶

Salicin/水杨苷 {[allProObj[0].p_purity_real_show]}

Salicin/水杨苷纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Salicin/水杨苷质控信息

Salicin/水杨苷生物活性

Salicin/水杨苷细胞实验

Salicin/水杨苷动物实验

Salicin/水杨苷临床研究

Salicin/水杨苷参考文献

Salicin/水杨苷实验方案

Salicin/水杨苷技术信息

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全球学术期刊中引用的产品

Salicin/水杨苷 质控信息

Salicin/水杨苷 生物活性

Salicin/水杨苷 细胞实验

Salicin/水杨苷 动物实验

Salicin/水杨苷 临床研究

Salicin/水杨苷 参考文献

Salicin/水杨苷 实验方案

Salicin/水杨苷 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Salicin/水杨苷纯度/质量文件产品仅供科研

Salicin/水杨苷质控信息

Salicin/水杨苷生物活性

Salicin/水杨苷细胞实验

Salicin/水杨苷动物实验

Salicin/水杨苷临床研究

Salicin/水杨苷参考文献

Salicin/水杨苷实验方案

Salicin/水杨苷技术信息