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/ Ketoprofen/酮洛芬

Ketoprofen/酮洛芬 {[allProObj[0].p_purity_real_show]}

货号：A164797 同义名： 酮基布洛芬 / RP-19583; 2-(3-benzoylphenyl)Propionic Acid

Ketoprofen 是一种双重 COX1/2 抑制剂，对人重组 COX-1 和 COX-2 的 IC50 分别为 0.5 μM 和 2.33 μM，用于关节炎等炎症疼痛机制研究。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Ketoprofen/酮洛芬 化学结构 CAS号：22071-15-4
Ketoprofen/酮洛芬 化学结构
CAS号：22071-15-4
Ketoprofen/酮洛芬 3D分子结构
CAS号：22071-15-4
Ketoprofen/酮洛芬 化学结构 CAS号：22071-15-4
Ketoprofen/酮洛芬 3D分子结构 CAS号：22071-15-4
规格 价格 会员价 库存 数量
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Ketoprofen/酮洛芬 纯度/质量文件 产品仅供科研

货号：A164797 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
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• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 COX ↓ COX-1 ↓ COX-2 ↓ 其他靶点 纯度
Piroxicam ✔ 98%
Salicylic acid ✔ 98%
Phenacetin ✔ 98%
Etodolac ✔ 99%
Flunixin meglumine ✔ 98%
Ibuprofen L-lysine ✔ 98%
Nabumetone ✔ 98%
Acemetacin ✔ 98%
Diflunisal ✔ 98%
Pranoprofen ✔ 98%
Ampiroxicam ✔ 98%
Meloxicam ✔ 98%
Sulindac ✔ 98%
Ketoprofen ✔ 98%
Mefenamic Acid ✔ 95%
Bromfenac sodium ✔ 98%
Oxaprozin ✔ 99%
Aspirin ✔ 99%
Nepafenac ✔ 98%
Zaltoprofen ✔ 99%
Salicin ✔ 98%
Suprofen ✔ 99%+
Xanthohumol ✔ 99%
Parecoxib ✔ 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

 		98%
Etoricoxib ✔ 99%
Niflumic Acid ✔ 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

 		99+%
Ibuprofen +

COX-1, IC50: 13 μM

 		+

COX-2, IC50: 370 μM

 		98%
Indomethacin ++

COX1, IC50: 0.28 μM

 		+

COX-2, IC50: 14 μM

 		97%
Lornoxicam ++++

COX-1, IC50: 5 nM

 		++++

COX-2, IC50: 8 nM

 		98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

 		+++

COX-2, IC50: 50 nM

 		99%
Asaraldehyde ✔ 98%
Naproxen +

COX-1, IC50: 8.7 μM

 		+

COX-2, IC50: 5.2 μM

 		98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

 		+++

COX-2, IC50: 200 nM

 		98%
NS-398 ++

COX-2, IC50: 3.8 μM

 		95%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

 		+++

COX-2, IC50: 150 nM

 		98%+
Nimesulide +

COX-2, IC50: 26 μM

 		98%
Lumiracoxib ++

COX-1, Ki: 3 μM

 		+++

COX-2, Ki: 60 nM

 		98%
Rutaecarpine ✔ 95%
Celecoxib ++++

COX-2, IC50: 40 nM

 		98%
Carprofen ++++

canine COX2, IC50: 30 nM

 		98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

 		++

COX-2 (human), IC50: 3.50 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ketoprofen/酮洛芬 生物活性

靶点

  • COX-1
描述 Cyclooxygenase (COX) is the rate-limiting enzyme for the synthesis of prostaglandins. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits both COX1 and COX2 in blood with the IC50 values of 0.11 μM and 0.88 μM, respectively[1]. Ketoprofen inhibited thromboxane B2 (TxB2) production in freshly isolated platelets from human blood with an IC50 value of 7.4 μM. The efficacy of ketoprofen in inhibiting LPS-induced TxB2 production in human mononuclear cells was determined with an IC50 value of 7.7 μM[2]. When HaCaT cells were irradiated with UVB (10 mJ/cm2), the activity of caspase-3 and the number of cells at the G2 phase were significant increased compared to cells without ketoprofen treatment. It was also shown that 100 μM Ketoprofen significantly provoked the accumulation of cyclin B1-cdc2-p21 complexes, as well as the amounts of Tyr15-phosphorylated cdc2 and p21 protein[3].
作用机制 Ketoprofen inhibits the activity of cyclooxygenase by conjugating with glucuronide and with coenzyme A[4].

Ketoprofen/酮洛芬 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
ICR mice Pain-related depression of nesting model Subcutaneous injection 0.01–10 mg/kg Single dose, administered 30 min before nesting Both ketoprofen and morphine produced dose-dependent blockade of acid-induced depression of nesting, whereas U69,593 had no significant effect. Pain. 2015 Jun;156(6):1153-1160
Mice C57BL/6J mice Subcutaneous injection 5 mg/kg Single injection Used for postoperative analgesia Nat Biotechnol. 2022 May;40(5):787-798
Pigs Pigs with acute respiratory disease outbreaks Oral 3 mg/kg Once daily for three days Ketoprofen reduced sickness behaviour and lowered the rectal temperature of the pigs, but had no significant effect on clinical signs, feed intake, or blood parameters. Ketoprofen treatment was associated with somewhat reduced weight gain over the 30-day follow-up period. Porcine Health Manag. 2018 Mar 6;4:7
Mice C57BL/6J mice Subcutaneous injection 5 mg/kg Single dose Used for postoperative analgesia Nat Methods. 2018 May;15(5):347-350
Mice Drd1-KO mice Subcutaneous injection 3 mg/kg Single administration Used as an analgesic Curr Biol. 2017 Aug 21;27(16):2465-2475.e3
Mice Brain metastasis model Subcutaneous injection 5 mg/kg Single dose Ketoprofen was used to alleviate pain in mice during the experiment ACS Appl Mater Interfaces. 2024 Jun 19;16(24):30860-30873
Mice Glioblastoma model Intraperitoneal injection 10 mg/kg Once daily for 3 days Used for analgesia, to prevent infection and pain Nat Commun. 2022 Oct 20;13(1):6211
Mice C57BL/6J mice Subcutaneous injection 5 mg/kg Once before surgery Used for analgesia before surgery Nature. 2021 Jul;595(7867):409-414
Nude mice Fat graft model Intramuscular injection 5 mg/kg Single dose Used to alleviate pain or discomfort in mice Plast Reconstr Surg. 2013 Oct;132(4):845-858

Ketoprofen/酮洛芬 动物研究

Dose Dog: 0.5 mg/kg - 2 mg/kg[5] (s.c.); 0.25 mg/kg - 5 mg/kg[5] (p.o.) Rat: 50 mg/kg[6] (p.o.)
Administration s.c., p.o.

Ketoprofen/酮洛芬 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01307020 Pain Phase 2 Completed - Germany ... 展开 >> Klinik und Polickinik für Mund-Kiefer-Gesichtschirurgie/Plastische Operationen Greifswald Greifswald, Mecklenburg-Vorpommern, Germany, 17475 Klinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum Schleswig Holstein, Campus Kiel Kiel, Schleswig-Holstein, Germany, 24105 Hungary Dr Tóth Bagi Zoltán Fogászati Rendeloje Budapest, Hungary, 1052 Italy Centro di Farmacologia Clinica per la Sperimentazione dei Farmaci Pisa, Italy, 56126 Centro di Ricerche Cliniche di Verona Srl. Policlinico G.B.Rossi Verona, Italy, 37134 Poland Gabinet Stomatologiczny Andrzej Wojtowicz AW Clinic Warsaw, Mazowieckie, Poland, 00-852 Dental Service spólka jawna Warszawa, Mazowieckie, Poland, 02-791 Spain Hospital Médico Quirúrgico de Conxo Santiago de Compostela, A Coruña, Spain, 15706 Facultad de Odontología. Departamento de Cirugía Bucal y Maxilofacial, University of Barcelona - Bellvitge Institute for Biomedical Research (IDIBELL) L'Hospitalet de Llobregat, Barcelona, Spain, 08907 Universidad Complutense de Madrid Madrid, Spain, 28040 Departamento de Estomatología, Facultad de Odontología. Universidad de Sevilla Sevilla, Spain, 41009 Departament d'Estomatologia, Clínica Odontològica, Universidad de Valencia - Fundació Lluís Alcanyís Valencia, Spain, 046010 Hospital General Universitario de Valencia Valencia, Spain, 46014 United Kingdom The School of Dentistry, College of Medical and Dental Sciences, University of Birmingham Birmingham, England, United Kingdom, B4 6 NN University Dental School Manchester Manchester, England, United Kingdom, M15 6FH University Dental Hospital Cardiff, Wales, United Kingdom, CF14 4 XY 收起 <<
NCT02092012 Pain Phase 4 Unknown July 2014 Turkey ... 展开 >> Erciyes Univercity Medicine Faculty Recruiting Kayseri, Turkey, 38039 Contact: selda kayaaltı, resident    +905558168918    drselda@hotmail.com    Contact: fatih ugur, assoc    +905359730073    ugurf@erciyes.edu.tr 收起 <<
NCT01307020 - Completed - -

Ketoprofen/酮洛芬 参考文献

[1]Cryer B, Feldman M. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am J Med. 1998;104(5):413-21.

[2]Grossman CJ, Wiseman J, et al. Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitors. Inflamm Res. 1995;44(6):253-7.

[3]Liu S, Mizu H, et al. Molecular response to phototoxic stress of UVB-irradiated ketoprofen through arresting cell cycle in G2/M phase and inducing apoptosis. Biochem Biophys Res Commun. 2007;364(3):650-5.

[4]Levoin N, Blondeau C, et al. Elucidation of the mechanism of inhibition of cyclooxygenases by acyl-coenzyme A and acylglucuronic conjugates of ketoprofen. Biochem Pharmacol. 2004;68(10):1957-69.

Ketoprofen/酮洛芬 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.93mL

0.79mL

0.39mL

19.66mL

3.93mL

1.97mL

39.33mL

7.87mL

3.93mL

Ketoprofen/酮洛芬 技术信息

CAS号22071-15-4
分子式C16H14O3
分子量 254.28
SMILES Code C2=C(C(C1=CC=CC=C1)=O)C=CC=C2C(C(O)=O)C
MDL No. MFCD00055790
别名 酮基布洛芬 ;RP-19583; 2-(3-benzoylphenyl)Propionic Acid; (R,S)-Ketoprofen; (±)-Ketoprofen
运输蓝冰
InChI Key DKYWVDODHFEZIM-UHFFFAOYSA-N
Pubchem ID 3825
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, room temperature
溶解方案

DMSO: 105 mg/mL(412.93 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: Ketoprofen | RP-19583;2-(3-benzoylphenyl)Propionic Acid;(R,S)-Ketoprofen;(±)-Ketoprofen | 酮基布洛芬 | Drug Standard | Anti-inflammation | Cyclooxygenase (COX) | Cyclooxygenase (COX) Inhibitor | COX | AmBeed-信号通路专用抑制剂 | Ketoprofen/酮洛芬 纯度/质量文件 | Ketoprofen/酮洛芬 亚型比较 | Ketoprofen/酮洛芬 生物活性 | Ketoprofen/酮洛芬 动物研究 | Ketoprofen/酮洛芬 临床数据 | Ketoprofen/酮洛芬 参考文献 | Ketoprofen/酮洛芬 实验方案 | Ketoprofen/酮洛芬 技术信息

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