There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Diclofenac Sodium (GP 45840) is a potent, nonselective anti-inflammatory agent that functions as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1]. Diclofenac Sodium triggers apoptosis in neural stem cells (NSCs) by activating the caspase cascade[3].
Diclofenac Sodium Salt/双氯芬酸钠 细胞实验
Cell Line
Concentration
Treated Time
Description
References
MRSE ATCC 35984
125 µg mL−1
24 hours
Inhibits MRSE growth
Adv Sci (Weinh). 2021 May 3;8(13):2100681.
MSSA ATCC 25923
125 µg mL−1
24 hours
Inhibits MSSA growth
Adv Sci (Weinh). 2021 May 3;8(13):2100681.
Mouse adult tail-tip fibroblasts (TTFs)
10 μM
1 week
Diclofenac significantly enhanced cardiac reprogramming efficiency in adult TTFs by about 3 fold
Nat Commun. 2019 Feb 20;10(1):674.
Mouse postnatal tail-tip fibroblasts (TTFs)
10 μM
1 week
Diclofenac significantly enhanced cardiac reprogramming efficiency in postnatal TTFs by 3-4 fold
Nat Commun. 2019 Feb 20;10(1):674.
Mouse embryonic fibroblasts (MEFs)
10 μM
1 week
Diclofenac did not substantially promote cardiac reprogramming in MEFs
Nat Commun. 2019 Feb 20;10(1):674.
Mouse primary hepatocytes
300 µM
24 hours
To evaluate the effect of diclofenac on lipid accumulation in mouse primary hepatocytes, results showed that diclofenac significantly increased neutral lipid accumulation and triglyceride levels.
Theranostics. 2022 Feb 21;12(5):2351-2369.
HepG2 cells
300 µM
24 hours
To evaluate the effect of diclofenac on lipid accumulation in hepatocytes, results showed that diclofenac significantly increased neutral lipid accumulation.
Theranostics. 2022 Feb 21;12(5):2351-2369.
MRSA ATCC 43300
125 µg mL−1
24 hours
Inhibits MRSA growth and does not easily induce drug-resistant mutations
Adv Sci (Weinh). 2021 May 3;8(13):2100681.
Intestinal microsomes
100 μmol/L
30 minutes
To evaluate the metabolic rate of diclofenac in intestinal microsomes, results showed that the formation rates of 4'-OH-DCF and 5-OH-DCF were reduced by 58% and 64%, respectively, in DSS-induced colitis mice.
Acta Pharm Sin B. 2020 Jan;10(1):123-135.
Hepatic microsomes
100 μmol/L
30 minutes
To evaluate the metabolic rate of diclofenac in hepatic microsomes, results showed that the formation rates of 4'-OH-DCF (CYP2C metabolite) and 5-OH-DCF (CYP3A metabolite) were reduced by 23% and 27%, respectively, in DSS-induced colitis mice.
Acta Pharm Sin B. 2020 Jan;10(1):123-135.
Fibroblast-like synoviocytes (FLS)
147.1 μmol/L (DC) and 73.6 μmol/L (LND)
24 hours
To verify the synergistic inhibitory effect of diclofenac (DC) and lonidamine (LND) on the survival, proliferation, and activation of FLS. Results showed that the combination treatment significantly reduced FLS viability and induced higher apoptosis rates (31.6%).
Acta Pharm Sin B. 2025 Jan;15(1):542-556.
Fadu cells
10ug/g
every other day
To investigate the effect of diclofenac on LAMP2A expression, results showed that diclofenac significantly decreased LAMP2A expression levels.
Theranostics. 2025 Feb 18;15(7):3207-3222.
Diclofenac Sodium Salt/双氯芬酸钠 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Rats
Carrageenan-induced rat paw edema model
Oral
10 mg/kg
Single dose
Evaluation of anti-inflammatory activity, diclofenac sodium showed 81.62% inhibition.
Acta Pharm Sin B. 2017 Mar;7(2):230-240
C57BL/6 mice
Osteoarthritis pain model
Oral
10 mg/kg
Daily for 4 weeks
To evaluate the analgesic effect of diclofenac on mechanical joint loading-induced osteoarthritis pain. Results showed that diclofenac significantly alleviated mechanical hypersensitivity and improved weight distribution after 2 weeks of treatment.
Arthritis Rheumatol. 2019 Jul;71(7):1078-1088
C57BL/6 mice
Hepatic steatosis model
Intraperitoneal injection
100 mg/kg
Every 12 hours for 24 hours
To evaluate the effect of diclofenac on hepatic lipid accumulation in mice, results showed that diclofenac significantly increased hepatic lipid accumulation and triglyceride levels.
Theranostics. 2022 Feb 21;12(5):2351-2369.
C57BL/6 mice
Head and neck squamous cell carcinoma model
Intraperitoneal injection
10 μg/g
Every other day for 10 days
To investigate the effect of diclofenac combined with PD-1 monoclonal antibody treatment, results showed that the combination treatment significantly inhibited tumor growth and enhanced CD8+ T cell infiltration.
Theranostics. 2025 Feb 18;15(7):3207-3222.
CD1 ICR mice
Skin and soft tissue infection model
Subcutaneous injection
80 mg/kg
Every 24 hours for 7 days
Combination with oxacillin significantly alleviates MRSA infection
Adv Sci (Weinh). 2021 May 3;8(13):2100681.
Nude mice
11q-deleted neuroblastoma xenograft model
Drinking water
250 mg/L
Nine consecutive days
To assess the effect of COX inhibition on tumor growth in an 11q-deleted neuroblastoma model, results showed diclofenac treatment significantly reduced tumor growth and PGE2 levels.
Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8070-5
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