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Demethoxycurcumin/去甲氧基姜黄素 {[allProObj[0].p_purity_real_show]}

货号：A982362 同义名： 脱甲氧姜黄 / Curcumin II; Desmethoxycurcumin

Demethoxycurcumin是一种主要的活性姜黄素类物质，具有抗炎特性，并通过诱导细胞凋亡对人类癌细胞表现出细胞毒性作用。

Demethoxycurcumin/去甲氧基姜黄素 化学结构 CAS号：22608-11-3
Demethoxycurcumin/去甲氧基姜黄素 化学结构
CAS号：22608-11-3
Demethoxycurcumin/去甲氧基姜黄素 3D分子结构
CAS号：22608-11-3
Demethoxycurcumin/去甲氧基姜黄素 化学结构 CAS号：22608-11-3
Demethoxycurcumin/去甲氧基姜黄素 3D分子结构 CAS号：22608-11-3
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Demethoxycurcumin/去甲氧基姜黄素 纯度/质量文件 产品仅供科研

货号：A982362 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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更多 >
产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		95%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 97%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 99%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine HCl ✔ 99%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 97%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		99%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 Autophagy ↓ 其他靶点 纯度
SBI-0206965 +++

ULK1, IC50: 108 nM

ULK2, IC50: 711 nM

 		95%
Hydroxychloroquine sulfate ✔ 99%
Valproic acid sodium ✔ HDAC 97%
PFK-015 ++

PFKFB3, IC50: 207 nM

 		99%+
MRT68921 HCl ++++

ULK1, IC50: 2.9 nM

ULK2, IC50: 1.1 nM

 		99%+
ROC-325 ✔ 99%+
Autophinib +++

Autophagy, IC50: 40 nM

 		99%
Lys05 ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Demethoxycurcumin/去甲氧基姜黄素 生物活性

描述 Monodemethoxycurcumin (demethoxycurcumin) is a major active curcuminoid and possess anti-inflammatory properties and also exert cytotoxic effects in human cancer cells via induction of apoptosis. DMC (demethoxycurcumin) significantly decreased NO secretion by 35-41% in our inflamed cell model[3]. Genes associated with DNA damage and repair, cell-cycle check point and apoptosis could be altered by DMC; in particular, 144 genes were found up-regulated and 179 genes down-regulated in NCI-H460 cells after exposure to DMC[4]. Administration of DMC to PD rats eased the protein expression of dopaminergic and apoptotic indices[5]. DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors[6].

Demethoxycurcumin/去甲氧基姜黄素 细胞实验

Cell Line
Concentration Treated Time Description References
BEAS-2B cells 1-4 μg/mL 48 h To study the effect of demethoxycurcumin on normal bronchial epithelial cells BEAS-2B, results showed no effect on cell growth. Int J Nanomedicine. 2015 Aug 5;10:5059-80
H460 cells 2-6 μg/mL 24-48 h To study the inhibitory effect of demethoxycurcumin on H460 cells, results showed H460 cells were more susceptible to apoptosis than A549 cells. Int J Nanomedicine. 2015 Aug 5;10:5059-80
A549 cells 2-6 μg/mL 24-48 h To study the inhibitory effect of demethoxycurcumin on A549 cells, results showed cell cycle arrest at G2/M phase and induction of apoptosis. Int J Nanomedicine. 2015 Aug 5;10:5059-80
SH-SY5Y cells 1 µM 24 h Evaluate the protective effect of demethoxycurcumin against Aβ42-induced neurotoxicity, results showed demethoxycurcumin protected 50-60% of cells from Aβ42-induced cell death Antioxidants (Basel). 2021 Oct 11;10(10):1592
N2a cells 1 µM 24 h Evaluate the protective effect of demethoxycurcumin against Aβ42-induced neurotoxicity, results showed demethoxycurcumin protected 50-60% of cells from Aβ42-induced cell death Antioxidants (Basel). 2021 Oct 11;10(10):1592
HeLa cells 10 µM 24 h Evaluate the effect of demethoxycurcumin on histone H3 citrullination in various cancer cells Philos Trans R Soc Lond B Biol Sci. 2023 Nov 20;378(1890):20220248
A375 cells 10 µM 24 h Evaluate the effect of demethoxycurcumin on histone H3 citrullination in various cancer cells Philos Trans R Soc Lond B Biol Sci. 2023 Nov 20;378(1890):20220248
SK-OV-3 cells 10 µM 24 h Evaluate the effect of demethoxycurcumin on histone H3 citrullination in various cancer cells Philos Trans R Soc Lond B Biol Sci. 2023 Nov 20;378(1890):20220248
A549 cells 10 µM 24 h Evaluate the effect of demethoxycurcumin on endogenous histone H3 citrullination Philos Trans R Soc Lond B Biol Sci. 2023 Nov 20;378(1890):20220248
HEK293T cells 10 µM 24 h Evaluate the effect of demethoxycurcumin on histone H3 citrullination in PAD2-overexpressing cells Philos Trans R Soc Lond B Biol Sci. 2023 Nov 20;378(1890):20220248

Demethoxycurcumin/去甲氧基姜黄素 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Nude mice GBM 8401/luc2 cell xenograft tumor model Oral gavage 30 mg/kg and 60 mg/kg Once daily for 21 days DMC significantly inhibited tumor volume and weight growth, with 60 mg/kg showing higher efficacy than 30 mg/kg, without affecting body weight or causing liver toxicity Int J Mol Sci. 2021 May 23;22(11):5503

Demethoxycurcumin/去甲氧基姜黄素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01982734 Pharmacokinetics of New Curcum... 展开 >>in Formulations Safety of New Curcumin Formulations 收起 << Early Phase 1 Completed - Germany ... 展开 >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 收起 <<
NCT01330810 Comparative Multidose Pharmaco... 展开 >>kinetics 收起 << Phase 1 Completed - United States, North Carolina ... 展开 >> UNC Department of Family Medicine Chapel Hill, North Carolina, United States, 27599 收起 <<
NCT03621865 Healthy Not Applicable Completed - France ... 展开 >> Biofortis Mérieux NutriSciences Saint-Herblain, France, 44800 收起 <<

Demethoxycurcumin/去甲氧基姜黄素 参考文献

[1]Somchit M, Changtam C, et al. Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 2014;15(4):1807-10.

[2]Wang X, Kim JR, et al. Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models. BMC Complement Altern Med. 2014 Mar 5;14:88.

[3]Somchit M, Changtam C, Kimseng R, Utaipan T, Lertcanawanichakul M, Suksamrarn A, Chunglok W. Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 2014;15(4):1807-10

[4]Ko YC, Hsu SC, Liu HC, Hsiao YT, Hsia TC, Yang ST, Hsu WH, Chung JG. Demethoxycurcumin alters gene expression associated with DNA damage, cell cycle and apoptosis in human lung cancer NCI-H460 cells in vitro. In Vivo. 2015 Jan-Feb;29(1):83-94. Erratum in: In Vivo. 2015 Nov-Dec;29(6):777

[5]Ramkumar M, Rajasankar S, Swaminathan Johnson WM, Prabu K, Venkatesh Gobi V. Demethoxycurcumin ameliorates rotenone-induced toxicity in rats. Front Biosci (Elite Ed). 2019 Jan 1;11:1-11

[6]Chueh FS, Lien JC, Chou YC, Huang WW, Huang YP, Huang JY, Kuo JY, Huang WN, Sheng SY, Tung HY, Chen HY, Peng SF. Demethoxycurcumin Inhibits In Vivo Growth of Xenograft Tumors of Human Cervical Cancer Cells. In Vivo. 2020 Sep-Oct;34(5):2469-2474

Demethoxycurcumin/去甲氧基姜黄素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.78mL

2.96mL

1.48mL

29.56mL

5.91mL

2.96mL

Demethoxycurcumin/去甲氧基姜黄素 技术信息

CAS号22608-11-3
分子式C20H18O5
分子量 338.35
SMILES Code O=C(CC(/C=C/C1=CC=C(O)C=C1)=O)/C=C/C2=CC=C(O)C(OC)=C2
MDL No. MFCD03427310
别名 脱甲氧姜黄 ;Curcumin II; Desmethoxycurcumin; DMC; Monodemethoxycurcumin
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, 2-8°C
溶解方案

DMSO: 105 mg/mL(310.33 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一

Tags: Demethoxycurcumin | 22608-11-3 | Curcumin II | Desmethoxycurcumin | Monodemethoxycurcumin | Bacterial Inhibitor | Apoptosis | Autophagy | Anti-infection | Apoptosis | Autophagy | Bacterial | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Demethoxycurcumin/去甲氧基姜黄素 纯度/质量文件 | Demethoxycurcumin/去甲氧基姜黄素 亚型比较 | Demethoxycurcumin/去甲氧基姜黄素 生物活性 | Demethoxycurcumin/去甲氧基姜黄素 临床数据 | Demethoxycurcumin/去甲氧基姜黄素 参考文献 | Demethoxycurcumin/去甲氧基姜黄素 实验方案 | Demethoxycurcumin/去甲氧基姜黄素 技术信息

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