Darifenacin hydrobromide/氢溴酸达非那新
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货号：A211196
同义名：
UK-88525 hydrobromide; Darifenacin(hydrobromide)
Darifenacin HCl 是一种 M3 选择性拮抗剂（pKi = 8.9），具有抗胆碱能及抗痉挛作用，常用于尿失禁及膀胱过度活跃的研究。
Darifenacin hydrobromide/氢溴酸达非那新 化学结构
Darifenacin hydrobromide/氢溴酸达非那新 3D分子结构
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Darifenacin hydrobromide/氢溴酸达非那新 纯度/质量文件 产品仅供科研
货号：A211196
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Darifenacin hydrobromide/氢溴酸达非那新 质控信息
Darifenacin hydrobromide/氢溴酸达非那新 生物活性
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描述
Darifenacin hydrobromide is a selective M3 muscarinic receptor antagonist with pKi of 8.5[3] [4] [5]
Darifenacin hydrobromide/氢溴酸达非那新 参考文献
[1] Miller DW, Hinton M, Chen F. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn. 2011 Nov;30(8):1633-8.
[2] Hegde SS, Choppin A, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol. 1997 Apr;120(8):1409-18.
[3] Hegde SS, Choppin A, Bonhaus D, Briaud S, Loeb M, Moy TM, Loury D, Eglen RM. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol. 1997 Apr;120(8):1409-18.
[4] Miller DW, Hinton M, Chen F. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn. 2011 Nov;30(8):1633-8.
[5] Iijima K, De Wachter S, Wyndaele JJ. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol. 2007 Sep;52(3):842-7.
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Darifenacin hydrobromide/氢溴酸达非那新 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
1.97mL
0.39mL
0.20mL
9.85mL
1.97mL
0.99mL
19.71mL
3.94mL
1.97mL
Darifenacin hydrobromide/氢溴酸达非那新 技术信息
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