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货号 产品名 纯度
A1684359 现货 Sulfosuccinimidyl oleate sodium

Sulfosuccinimidyl oleate sodium是一种长链脂肪酸,作为有效且不可逆的线粒体呼吸链抑制剂。它通过结合小胶质细胞上的 CD36 受体,阻止脂肪酸转运,具有显著的抗炎作用。该化合物在代谢和炎症相关疾病研究中具有潜在的应用价值。

99%+
A821402 现货 ABT-737

ABT-737 是一种选择性的 Bcl-2 家族蛋白抑制剂,能够有效抑制 Bcl-2Bcl-xLBcl-w 的活性,IC50 值分别为 30.3 nM、78.7 nM 和 197.8 nM。ABT-737 主要用于研究细胞凋亡、抗癌治疗和增强肿瘤对化疗药物的敏感性。

99%+
A155702 现货 Pinosylvin/赤松素

Pinosylvin, a natural product isolated and purified from the herbs of Pinus yunnanensis, can induce autophagy via AMPK activation. Pinosylvin has anti-inflammatory activity, may be utilized as a phytotherapic agent for the prevention of cardiovascular inflammatory diseases.

99%+
A142087 现货 GSK2578215A

GSK2578215A is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2, respectively.

99%+
A270430 现货 AC-55649

AC55649 is an agonist of the retinoic acid receptor β (RAR-β).

99%+
A247947 现货 N-dodecanoyl-L-Homoserine lactone

N-dodecanoyl-L-Homoserine lactone是一种群体感应信号分子,可抑制铜绿假单胞菌 (Pseudomonas aeruginosa) 生物膜的形成,通过阻止细菌的群体感应机制发挥抗菌作用,适用于抗感染及微生物研究。

97%
A1209424 现货 JGB1741

JGB1741是一种特异性的 SIRT1 抑制剂,IC50 为 15 μM,通过增加乙酰化 p53 的水平,调节 Bax/Bcl2 比率,诱导细胞凋亡,具有用于乳腺癌等肿瘤研究的潜力。

97%
A597744 现货 SU11274

SU11274 is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFRβ, EGFR or Tie2.

99%+
A823065 现货 ZPCK

ZPCK 是吉西他滨的前体,具备口服活性,旨在提高其口服生物利用度。

96%
A239847 现货 Peiminine/贝母素乙

Peiminine, a natural product isolated and purified from the bulbus of Fritillaria thunbergii Miq., is an effective inhibitor for lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury.It induces autophagic cell death thus represses colorectal carcinoma tumor growth.

98+%
A207157 现货 Tolcapone/托卡朋

Tolcapone is a potent, selective and orally active catechol-O-methyltransferase (COMT) inhibitor with Ki of 30 nM.

99%+
A124609 现货 Danshensu/丹参素

Danshensu, a herbal preparation used in traditional Chinese medicine, possesses potential antitumor and antiangiogenesis effects.

99%+
A123867 现货 Oroxin B/木蝴蝶苷B

Oroxin B, a natural product isolated and purified from the roots of Scutellaria baicalensis., can selectively induce tumor-suppressive ER stress and concurrently inhibit tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy.

99%+
A136104 现货 FTI-277 HCl

FTI-277 HCl is an inhibitor of farnesyl transferase (FTase) and a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.

98%
A348526 现货 Deoxypodophyllotoxin/脱氧鬼臼毒素

Deoxypodophyllotoxin, a natural microtube inhibitor isolated and purified from the roots of Dysosma versipellis (Hance) M.Cheng ex Ying, is cytotoxic agent, antineoplastic agent and potent antitumor agent and may be beneficial in regulating the immediate-type allergic reaction.

98%
A1541513 现货 SBI-0640756/SBI 0640756抑制剂

SBI-0640756是一种 eIF4G1 抑制剂,能够有效破坏 eIF4F 复合体。它在抑制癌细胞增殖和研究翻译调控方面具有潜在的应用价值。

99%
A1155098 现货 WYC-209

WYC-209 is a RAR agonist which induces apoptosis primarily via the caspase 3 pathway.

99%+
A1174034 现货 Niacin-d4

Niacin-d4是 Niacin 的氘代物,而 Niacin (烟酸) 是维生素 B 家族的一员。

98% 98%atom%D
A866594 现货 Rilmenidine phosphate

Rilmenidine Phosphate is an oxazole-derived agonist of adrenergic receptor α2 and Imidazoline receptor, used in trials studying the treatment of hypertension and chronic kidney disease.

98%+
A1249464 现货 SID-852843

SID-852843是一种 WNV NS2B-NS3 蛋白酶抑制剂,能够抑制其活性,IC50 为 0.105 μM,广泛用于病毒感染的研究。

98%
产品名 Autophagy 其他靶点 纯度
SBI-0206965 +++

ULK2, IC50: 711 nM

ULK1, IC50: 108 nM

97%
Hydroxychloroquine sulfate 99%
Valproic acid sodium HDAC 97%
PFK-015 ++

PFKFB3, IC50: 207 nM

99%+
MRT68921 hydrochloride ++++

ULK2, IC50: 1.1 nM

ULK1, IC50: 2.9 nM

99%+
ROC-325 99%+
Autophinib +++

Autophagy, IC50: 40 nM

97%
Lys05 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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