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Catharanthine/长春质碱
Catharanthine/长春质碱
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货号：A247451
同义名：
(+)-3,4-Didehydrocoronaridine
Catharanthine 在10 μM时表现出对毒蕈碱受体的拮抗作用，并以IC50值59.6 μM完全抑制了烟碱受体介导的膈肌收缩。作为长春花碱和长春新碱的前体，它也能抑制微管蛋白自组装成微管。
Catharanthine/长春质碱 化学结构
Catharanthine/长春质碱 3D分子结构
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Catharanthine/长春质碱 纯度/质量文件 产品仅供科研
货号：A247451
标准纯度：
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Catharanthine/长春质碱 质控信息
Catharanthine/长春质碱 生物活性
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Catharanthine is a constituent of anticancer vinca alkaloids. Catharanthine evoked concentration-dependent decreases (I(max) >98%) in endothelium-independent tonic responses of aortic rings to phenylephrine (PE) and KCl (IC50 = 28 µM for PE and IC50 = 34 µM for KCl) and of third-order branches of the small mesenteric artery (MA) (IC50 = 3 µM for PE and IC50 = 6 µM for KCl). Catharanthine also increased the inner vessel wall diameter (IC50 = 10 µM) and reduced intracellular free Ca2+ levels (IC50 = 16 µM) in PE-constricted MAs. Patch-clamp studies demonstrated that catharanthine inhibited voltage-operated L-type Ca2+ channel (VOCC) currents in cardiomyocytes and VSMCs (IC50 = 220 µM and IC50 = 8 µM, respectively) of MA[3]
Catharanthine/长春质碱 参考文献
[1] Pereira DM, Ferreres F, et al. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine. 2010 Jul;17(8-9):646-52.
[2] Prakash V, Timasheff SN. Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline. Biochemistry. 1991 Jan 22;30(3):873-80.
[3] Jadhav A, Liang W, Papageorgiou PC, Shoker A, Kanthan SC, Balsevich J, Levy AS, Heximer S, Backx PH, Gopalakrishnan V. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345(3):383-92.
Catharanthine/长春质碱 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.97mL
0.59mL
0.30mL
14.86mL
2.97mL
1.49mL
29.72mL
5.94mL
2.97mL
Catharanthine/长春质碱 技术信息
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