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货号 产品名 纯度
A503709 现货 BML-210

BML-210 is the HDAC inhibitor, and its mechanism of action has not been characterized.

98%
A421613 现货 Nirogacestat

PF-3084014 is a reversible inhibitor of γ-secretase with IC50 of 6.2 nM.

99%+
A136104 现货 FTI-277 HCl

FTI-277 HCl is an inhibitor of farnesyl transferase (FTase) and a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.

98%
A348526 现货 Deoxypodophyllotoxin/脱氧鬼臼毒素

Deoxypodophyllotoxin, a natural microtube inhibitor isolated and purified from the roots of Dysosma versipellis (Hance) M.Cheng ex Ying, is cytotoxic agent, antineoplastic agent and potent antitumor agent and may be beneficial in regulating the immediate-type allergic reaction.

98%
A961925 现货 NVS-CECR2-1

NVS-CECR2-1 is a potent and selective CECR2 (cat eye syndrome chromosome region, candidate 2) inhibitor with IC50 of 47 nM.

98%
A1340291 现货 TMI-1

Disintegrin and Metalloproteinase Domain-Containing Protein 17 (ADAM17; TACE) Inhibitors, MMP-1 (Interstitial Collagenase) Inhibitors, MMP-13 (Collagenase 3) Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-7 (Matrilysin) Inhibitors, MMP-9 (Gelatinase B) Inhibitors, Signal Transduction Modulators

99%+
A1365253 现货 T025

T025是一种具有口服活性的 Cdc2-like 激酶 (CLK) 抑制剂,对多种 CLK 激酶亚型的 Kd 值在纳摩尔级别 (如 CLK2 为 0.096 nM)。T025 可诱导 caspase-3/7 介导的细胞凋亡,适用于 MYC 驱动的肿瘤和细胞增殖异常的疾病研究。

99%+
A1398849 现货 Casein Kinase inhibitor A86

Casein Kinase inhibitor A86是一种有效且具有口服活性的酪蛋白激酶 1α (CK1α) 抑制剂,同时也抑制 CDK7 (TFIIH) 和 CDK9 (P-TEFb),并能诱导白血病细胞凋亡 (apoptosis),具有抗白血病活性。

95%
A1324931 现货 PD173952

PD173952 是一种酪氨酸激酶抑制剂,其对 LynAbl 和 Csk 的 IC50 值分别为 0.3 nM、1.7 nM 和 6.6 nM。它也是 Myt1 的抑制剂,Ki 为 8.1 nM,并可诱导细胞凋亡

97%
A496529 现货 Costunolide/木香烃内酯

Costunolide shows anti-inflammatory and anti-oxidant activities and also induces apoptosis. It is a sesquiterpene lactone isolated from stem bark of Magnolia sieboldii,

98%
A465968 现货 SB-218078

Inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics.

98%
A685594 现货 PD184161

PD184161 is an orally-active MEK inhibitor with antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity.

99%+
A866594 现货 Rilmenidine phosphate

Rilmenidine Phosphate is an oxazole-derived agonist of adrenergic receptor α2 and Imidazoline receptor, used in trials studying the treatment of hypertension and chronic kidney disease.

98%+
A1365046 现货 AOH1160

AOH1160是一种有效的、可口服的增殖细胞核抗原 (PCNA) 抑制剂,能够干扰 DNA 复制并阻断同源重组介导的 DNA 修复,进而导致细胞周期停滞并诱导细胞凋亡AOH1160 适用于研究 DNA 损伤反应和癌症治疗中的潜在应用。

99%+
A1176717 现货 SSE15206

SSE15206 is a microtubule depolymerizing agent which inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin. It causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation.

99%+
A202142 现货 LJH685

LJH685 is a potent pan-RSK inhibitor with IC50 of 6 nM, 5 nM and 4 nM for RSK1, RSK2, and RSK3, respectively.

99%+
A353729 现货 Acetylshikonin/乙酰紫草素

Acetyl shikonin, a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc., inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated, and is a non-selective cytochrome P450 inhibitor.

98%
A724348 现货 1A-116

1A-116 is a specific Rac1 inhibitor.

99%+
A746103 现货 Oncrasin-1

Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations and also leads to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.

99%+
A1145390 现货 Rotundifuran/蔓荆呋喃

Rotundifuran是一种从马鞭草属植物中分离的二萜类化合物,能通过抑制细胞周期进程并诱导凋亡,抑制骨髓性白血病细胞的增殖。

98%
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