Demethoxycurcumin

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Chemical Structure| 22608-11-3 同义名 : 脱甲氧姜黄 ;Curcumin II; Desmethoxycurcumin; DMC; Monodemethoxycurcumin
CAS号 : 22608-11-3
货号 : A982362
分子式 : C20H18O5
纯度 : 99%+
分子量 : 338.35
MDL号 : MFCD03427310
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(310.33 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Monodemethoxycurcumin (demethoxycurcumin) is a major active curcuminoid and possess anti-inflammatory properties and also exert cytotoxic effects in human cancer cells via induction of apoptosis. DMC (demethoxycurcumin) significantly decreased NO secretion by 35-41% in our inflamed cell model[3]. Genes associated with DNA damage and repair, cell-cycle check point and apoptosis could be altered by DMC; in particular, 144 genes were found up-regulated and 179 genes down-regulated in NCI-H460 cells after exposure to DMC[4]. Administration of DMC to PD rats eased the protein expression of dopaminergic and apoptotic indices[5]. DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01982734 Pharmacokinetics of New Curcum... 展开 >>in Formulations Safety of New Curcumin Formulations 收起 << Early Phase 1 Completed - Germany ... 展开 >> University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 收起 <<
NCT01330810 Comparative Multidose Pharmaco... 展开 >>kinetics 收起 << Phase 1 Completed - United States, North Carolina ... 展开 >> UNC Department of Family Medicine Chapel Hill, North Carolina, United States, 27599 收起 <<
NCT03621865 Healthy Not Applicable Completed - France ... 展开 >> Biofortis Mérieux NutriSciences Saint-Herblain, France, 44800 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.78mL

2.96mL

1.48mL

29.56mL

5.91mL

2.96mL
参考文献

[1]Somchit M, Changtam C, et al. Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 2014;15(4):1807-10.

[2]Wang X, Kim JR, et al. Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models. BMC Complement Altern Med. 2014 Mar 5;14:88.

[3]Somchit M, Changtam C, Kimseng R, Utaipan T, Lertcanawanichakul M, Suksamrarn A, Chunglok W. Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 2014;15(4):1807-10

[4]Ko YC, Hsu SC, Liu HC, Hsiao YT, Hsia TC, Yang ST, Hsu WH, Chung JG. Demethoxycurcumin alters gene expression associated with DNA damage, cell cycle and apoptosis in human lung cancer NCI-H460 cells in vitro. In Vivo. 2015 Jan-Feb;29(1):83-94. Erratum in: In Vivo. 2015 Nov-Dec;29(6):777

[5]Ramkumar M, Rajasankar S, Swaminathan Johnson WM, Prabu K, Venkatesh Gobi V. Demethoxycurcumin ameliorates rotenone-induced toxicity in rats. Front Biosci (Elite Ed). 2019 Jan 1;11:1-11

[6]Chueh FS, Lien JC, Chou YC, Huang WW, Huang YP, Huang JY, Kuo JY, Huang WN, Sheng SY, Tung HY, Chen HY, Peng SF. Demethoxycurcumin Inhibits In Vivo Growth of Xenograft Tumors of Human Cervical Cancer Cells. In Vivo. 2020 Sep-Oct;34(5):2469-2474