There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, reversible, selective inhibitor of acetylcholinesterase (AChE) used in China for the treatment of Alzheimer's disease[3]. Inhibition of fetal bovine serum acetylcholinesterase by (-)-Huperzine A was 35-fold more potent than (+)-Huperzine A, with KI values of 6.2 nM and 210 nM, respectively. In addition, (-)-Huperzine A was 88-fold more potent in inhibiting Torpedo acetylcholinesterase than (+)-Huperzine A, with KI values of 0.25 mM and 22 mM, respectively[4]. Huperzine A treatment significantly decreased the level of intracellular Aβ42 and ameliorated oligomeric Aβ42 induced mitochondrial dysfunctions in primary cortical neurons[5].
(-)-Huperzine A/石杉碱甲 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Rat cortical neurons
1 μM and 10 μM
24 h
To evaluate the effects of HupA on iron overload-induced LIP level increase. Results showed that HupA significantly decreased the iron overload-induced LIP level increase.
Acta Pharmacol Sin. 2016 Nov;37(11):1391-1400
Rat cortical neurons
1 μM and 10 μM
24 h
To evaluate the effects of HupA on iron overload-induced ATP decrease. Results showed that HupA significantly ameliorated the iron overload-induced ATP decrease.
Acta Pharmacol Sin. 2016 Nov;37(11):1391-1400
Rat cortical neurons
1 μM and 10 μM
24 h
To evaluate the effects of HupA on iron overload-induced ROS formation. Results showed that HupA significantly inhibited the iron overload-induced increase in ROS.
Acta Pharmacol Sin. 2016 Nov;37(11):1391-1400
Rat cortical neurons
1 μM and 10 μM
24 h
To evaluate the protective effects of HupA against iron overload-induced neuronal damage. Results showed that HupA significantly attenuated the iron overload-induced decrease in neuronal cell viability and improved neuronal morphology.
Acta Pharmacol Sin. 2016 Nov;37(11):1391-1400
SH-SY5Y cells
10 μM
24 h
HupA significantly increased ADAM10 levels, decreased BACE1 levels, increased sAPPα and C83 fragments, and decreased sAPPβ and C99 fragments, indicating that HupA modulates APP processing by enhancing the nonamyloidogenic pathway.
Neuropsychopharmacology. 2011 Apr;36(5):1073-89
(-)-Huperzine A/石杉碱甲 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
High-fat diet-induced obese mice and ob/ob mice
Intragastric administration
0.1 mg/kg/day and 0.3 mg/kg/day
Once daily for 3 months
Hup A (0.1 mg/kg/day) improved both the abilities of object recognition and spatial memory in HFD-fed mice, but not in ob/ob mice. Furthermore, Hup A treatment significantly upregulated the insulin and phosphorylated Akt levels in the cortex of HFD-fed mice, but not ob/ob mice. In addition, Hup A (0.3 mg/kg/day) significantly decreased cortical β-secretase (BACE1) expression.
Acta Pharmacol Sin. 2020 Feb;41(2):145-153
C57BL/6N mice
Chronic intermittent hypoxia model
Intraperitoneal injection
0.1 mg/kg/day
Once daily for 21 days
Huperzine A-Liposomes (HuA-LIP) significantly ameliorated cognitive dysfunction and neuronal damage in CIH mice, elevated T-SOD and GSH-Px abilities, decreased MDA content, reduced brain iron levels by downregulating TfR1, hepcidin, and FTL expression, and improved synaptic plasticity by activating the PKAα/Erk/CREB/BDNF signaling pathway and elevating MAP2, PSD95, and synaptophysin.
Int J Nanomedicine. 2023 Feb 17;18:843-859
APP/PS1 double-transgenic mice
Alzheimer's disease model
Intranasal administration
167 and 500 μg/kg
Once daily for 4 months
HupA reduced Aβ burden and generation, enhanced nonamyloidogenic processing of APP by inhibiting GSK3α/β activity and enhancing β-catenin levels, suggesting its neuroprotective effects involve not only AChE inhibition and antioxidation but also modulation of the Wnt/β-catenin signaling pathway.
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