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首页 / 抑制剂/激动剂 / 神经信号通路 / AChR / Pancuronium dibromide/泮库溴铵

Pancuronium dibromide/泮库溴铵 {[allProObj[0].p_purity_real_show]}

货号：A737050 同义名： Pavulon; Pancuronium(dibromide)

Pancuronium dibromide是一种竞争性乙酰胆碱受体拮抗剂，通过竞争性地与神经肌肉接头的尼古丁受体结合，导致骨骼肌放松和麻痹。

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Pancuronium dibromide/泮库溴铵 化学结构 CAS号：15500-66-0
Pancuronium dibromide/泮库溴铵 化学结构
CAS号：15500-66-0
Pancuronium dibromide/泮库溴铵 3D分子结构
CAS号：15500-66-0
Pancuronium dibromide/泮库溴铵 化学结构 CAS号：15500-66-0
Pancuronium dibromide/泮库溴铵 3D分子结构 CAS号：15500-66-0
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Pancuronium dibromide/泮库溴铵 纯度/质量文件 产品仅供科研

货号：A737050 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

hAChE, IC50: 11.6 nM

bAChE, IC50: 8.12 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		95%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 97%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 99%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine HCl ✔ 99%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 97%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		99%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α7 nAChRs, IC50: 122 nM

α4β2 nAChRs, IC50: 49 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Pancuronium dibromide/泮库溴铵 生物活性

靶点

  • AChR
描述 Pancuronium Dibromide is a competitive AChR antagonist.Pancuronium (10 mg/kg ) reduced ACh-induced bronchoconstriction. At doses which produce 100% neuromuscular blockade, both pancuronium (0.04 mg/kg) and gallamine (4 mg/kg) potentiated vagally-induced bronchoconstriction[3].Competitive block of embryonic-type nicotinic acetylcholine receptor channels by pancuronium or atracurium after preincubation of outside-out patches with the respective blocker[4]. Moreover, Pancuronium may reduce the sodium current by interacting with the sodium channels in both the resting and open states[5].

Pancuronium dibromide/泮库溴铵 细胞实验

Cell Line
Concentration Treated Time Description References
C2C12 myotubes 3μM To investigate the antagonistic effect of Pavulon on nicotinic acetylcholine receptors (nAChR), results showed that Pavulon completely blocked the carbachol-induced Ca2+ response. Br J Pharmacol. 1996 Apr;117(8):1785-91.
Mouse hemidiaphragm endplate-rich region 10^-5 M 3 min To investigate the effect of Pavulon on acetylcholine release, results showed Pavulon significantly reduced the [3H]-ACh release evoked by high-frequency stimulation. Br J Pharmacol. 1989 May;97(1):65-70.

Pancuronium dibromide/泮库溴铵 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Male ddY mice Diaphragm muscle Bath application 0.05 μM 30 min pretreatment To investigate the inhibitory effect of non-contractile Ca2+ mobilization on contractile Ca2+ transients Br J Pharmacol. 1995 Jan;114(2):461-7
Mice Myotonia (mto) mutant mice Subcutaneous injection 0.05 mg Single dose To study the effect of neuromuscular blocking agent on myotonic discharges, results showed no change in the character of the myotonia. J Neurosci. 1982 Jul;2(7):924-33

Pancuronium dibromide/泮库溴铵 参考文献

[1]Lowenick CV, Krampfl K, et al. Open channel and competitive block of nicotinic receptors by pancuronium and atracurium. Eur J Pharmacol. 2001 Feb 9;413(1):31-5.

[2]Melnikov AL, Malakhov KY, et al. Cardiac effects of non-depolarizing neuromuscular blocking agents pancuronium,vecuronium, and rocuronium in isolated rat atria. Gen Pharmacol. 1999 Oct;33(4):313-7.

[3]Fryer AD, Maclagan J. Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch Pharmacol. 1987 Apr;335(4):367-71.

[4]Löwenick CV, Krampfl K, Schneck H, Kochs E, Bufler J. Open channel and competitive block of nicotinic receptors by pancuronium and atracurium. Eur J Pharmacol. 2001 Feb 9;413(1):31-5.

[5]Maestrone E, Magnelli V, Nobile M, Usai C. Extracellular pancuronium affects sodium current in chick embryo sensory neurones. Br J Pharmacol. 1994 Jan;111(1):283-7.

Pancuronium dibromide/泮库溴铵 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.36mL

0.27mL

0.14mL

6.82mL

1.36mL

0.68mL

13.65mL

2.73mL

1.36mL

Pancuronium dibromide/泮库溴铵 技术信息

CAS号15500-66-0
分子式C35H60Br2N2O4
分子量 732.67
SMILES Code C[N+]1([C@@H]2[C@@H](OC(C)=O)C[C@@](CC[C@]3([H])[C@]4([H])CC[C@@]5(C)[C@@]3([H])C[C@H]([N+]6(C)CCCCC6)[C@@H]5OC(C)=O)([H])[C@]4(C)C2)CCCCC1.[Br-].[Br-]
MDL No. MFCD00079223
别名 Pavulon; Pancuronium(dibromide)
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, room temperature
溶解方案

DMSO: 105 mg/mL(143.31 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(136.49 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Pancuronium dibromide | 15500-66-0 | Membrane Transporter/Ion Channel | Neuronal Signaling | nAChR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Pancuronium dibromide/泮库溴铵 纯度/质量文件 | Pancuronium dibromide/泮库溴铵 亚型比较 | Pancuronium dibromide/泮库溴铵 生物活性 | Pancuronium dibromide/泮库溴铵 参考文献 | Pancuronium dibromide/泮库溴铵 实验方案 | Pancuronium dibromide/泮库溴铵 技术信息

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