There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Galanthamine Hydrobromide is acetylcholinesterase inhibitor (AChEI) and a neuroactive drug capable of passing through the blood–brain barrier and can slow down the effects of AD[3]. Incubation of the cells for 48 h with 300 nM galantamine doubled the density of α7 nicotinic receptors and tripled the expression of the antiapoptotic protein Bcl-2[4]. Moreover, pretreatment with galantamine (8 mg/kg, i.m.) prevented the reduction of EPSC (excitatory postsynaptic currents) frequency observed at 6-9 days after the soman challenge[5].
Galanthamine HBr/氢溴酸加兰他敏 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HT-22 cells
10 μM
24 hours
To investigate the effect of galantamine on Mi-sup-induced inflammatory response in HT-22 cells. Galantamine reduced the Mi-sup-induced increase in NF-κB p65 levels and expression of pro-inflammatory cytokines (IL-1β and IL-6).
J Neuroinflammation. 2018 Apr 18;15(1):112
BV-2 cells
10 μM
24 hours
To investigate the effect of galantamine on LPS-induced inflammatory response in BV-2 cells. Galantamine reduced the LPS-induced increase in NF-κB p65 levels.
J Neuroinflammation. 2018 Apr 18;15(1):112
α7 nACh receptors stably expressed in HEK293 cells
10 nM to 10 μM
40 s pre-application (60 s for 0.01 μM), followed by 250 ms co-application with ACh
To validate modulatory effects of galanthamine on α7 nACh receptors in HEK293 cells. Results aligned with oocyte experiments, showing no positive modulation and inhibition at high concentrations (100 μM).
Br J Pharmacol. 2018 Jul;175(14):2911-2925
RAW 264.7 cells
10 μmol/L
24 hours
To investigate the effect of Galanthamine on LPS-induced migration of RAW 264.7 cells, results showed that Galanthamine significantly inhibited LPS-induced cell migration.
Acta Pharm Sin B. 2020 Oct;10(10):1926-1942
Galanthamine HBr/氢溴酸加兰他敏 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Kunming mice
LPS-induced neuroinflammation model
Intraperitoneal injection
4 mg/kg
Once daily for 14 days
To investigate the effect of galantamine on LPS-induced cognitive impairment and neuroinflammation. Galantamine improved LPS-induced deficits in spatial learning and memory, reduced the expression of CD11b, GFAP, NF-κB p65, and pro-inflammatory cytokines in the hippocampus, and increased the levels of synapse-associated proteins (SYN and PSD-95).
J Neuroinflammation. 2018 Apr 18;15(1):112
Wistar rats
Adolescent intermittent ethanol (AIE) exposure model
Intraperitoneal injection
4 mg/kg
In the prevention study, administered 30 min prior to each gavage, totaling 16 doses; in the restoration study, administered daily for 2 weeks starting from P57
Galanthamine prevented and reversed AIE-induced neuroimmune signaling and loss of hippocampal neurogenesis. In the prevention study, galantamine pretreatment blocked AIE induction of CCL2, HMGB1, and COX-2, and prevented the reduction in neurogenesis. In the restoration study, galantamine treatment reversed AIE induction of these inflammatory markers and restored neurogenesis.
J Neuroinflammation. 2021 Sep 16;18(1):212
Mice
Caerulein-induced acute pancreatitis model
Intraperitoneal injection
1, 4, or 6 mg/kg body weight
Administered once 1 hour before the first caerulein injection and again 30 minutes after the third injection
Galanthamine significantly attenuated pancreatic histologic injury, reflected by a reduction in serum amylase and pancreatic inflammatory cytokines and an increase in the anti-inflammatory cytokine IL-10 in the serum. These beneficial effects were not altered by bilateral subdiaphragmatic vagotomy, knockout of either choline acetyltransferase-positive T cells or α7nAChR, or administration of the nAChR ganglionic blocker mecamylamine or the more selective α7nAChR antagonist methyllycaconitine.
Mol Med. 2023 Oct 31;29(1):149
Mice
Opa1–/– mice and aged WT mice
Oral
3.28 mg/kg bodyweight/d
Daily for 90 days (Opa1–/– mice) or 18 weeks (aged mice)
To assess the impact of long-term Galanthamine on chronic inflammation in FMF-KI mice. Results demonstrated significant attenuation of splenomegaly, reduced inflammatory cell infiltration (e.g., spleen and subcutaneous air pouch), decreased serum amyloid A (SAA) levels, and improved anemia. Notably, Galanthamine's effects persisted in vagotomized or α7nAChR-KO mice, suggesting a mechanism independent of the classical cholinergic anti-inflammatory pathway.
Mol Med. 2022 Dec 9;28(1):148
Sprague-Dawley rats
Cardiac ischemia/reperfusion (I/R) model
Isolated heart perfusion
5 × 10^-8 M
30 min ischemia followed by 40 min reperfusion
To investigate the effect of galantamine on cardiac ischemia/reperfusion injury in isolated hearts. Results showed that galantamine treatment significantly improved left ventricular function (LVDP, ±dP/dt, WP) without affecting heart rate.
Mol Med. 2017 Jul;23:120-133
Male adult Wistar rats
Experimental model of dementia induced by scopolamine
Intraperitoneal injection
1 mg/kg
For 9 consecutive days
To evaluate the neuroprotective effects of galantamine in scopolamine-induced dementia in rats. Results showed that galantamine significantly increased brain ACh levels, improved recognition memory and habituation, and restored the cholinergic system influence index.
Antioxidants (Basel). 2022 Feb 12;11(2):374
NOD mice
Type 1 diabetes model
Intraperitoneal injection
1 mg/kg
Daily for 20 weeks
To study the preventive effects of galantamine in type 1 diabetes, results showed that galantamine significantly delayed the onset of hyperglycemia, reduced pancreatic islet inflammation, and decreased serum levels of anti-insulin antibodies.
搜索
HazMat Fee +
