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首页 / 抑制剂/激动剂 / 神经信号通路 / AChR / Ipratropium bromide/异丙托溴铵

Ipratropium bromide/异丙托溴铵 {[allProObj[0].p_purity_real_show]}

货号：A163960 同义名： Sch 1000; Ipratropium (bromide)

Ipratropium bromide是阿托品生物碱的合成衍生物，具有抗胆碱能性质。

Ipratropium bromide/异丙托溴铵 化学结构 CAS号：22254-24-6
Ipratropium bromide/异丙托溴铵 化学结构
CAS号：22254-24-6
Ipratropium bromide/异丙托溴铵 3D分子结构
CAS号：22254-24-6
Ipratropium bromide/异丙托溴铵 化学结构 CAS号：22254-24-6
Ipratropium bromide/异丙托溴铵 3D分子结构 CAS号：22254-24-6
规格 价格 会员价 库存 数量
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Ipratropium bromide/异丙托溴铵 纯度/质量文件 产品仅供科研

货号：A163960 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		95%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 97%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 99%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine HCl ✔ 99%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 97%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		99%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M2 mAChR, Ki: 0.1 nM

M4 mAChR, Ki: 0.21 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ipratropium bromide/异丙托溴铵 生物活性

靶点

  • mAChR
描述 Ipratropium Bromide, as short‐acting anticholinergic, is indicated for the maintenance treatment of bronchospasm associated with COPD (chronic obstructive pulmonary disease), including chronic bronchitis and emphysema[3]. Both IB (Ipratropium Bromide) and AS (Albuterol Sulfate) elicit significant bronchodilation, although the magnitude of the bronchodilator response is greater following IB[4]. Moreover, routine nebulized ipratropium bromide premedication for bronchoscopy could be useful and beneficial[5].

Ipratropium bromide/异丙托溴铵 细胞实验

Cell Line
Concentration Treated Time Description References
ILC2s 0.4 mg/ml 4 h ACh potently activated ILC2s as measured by intracellular cytokine staining of IL-5 and IL-13. Sci Immunol. 2021 Mar 5;6(57):eabe3218.
human isolated bronchial smooth muscle 10 nM 3.0 h To evaluate the inhibitory effect of ipratropium on human bronchial smooth muscle and its duration. Results showed that the inhibitory effect of ipratropium was short-lasting, with 110% recovery of response after 6 h. Br J Pharmacol. 2006 Jun;148(3):291-8.
guinea-pig isolated tracheal smooth muscle 10 nM 0.5 h To evaluate the inhibitory effect of ipratropium on carbachol-induced contraction and its duration. Results showed that the inhibitory effect of ipratropium was short-lasting, with 70% recovery of response after 4.5 h. Br J Pharmacol. 2006 Jun;148(3):291-8.

Ipratropium bromide/异丙托溴铵 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Guinea pigs ACh-induced bronchoconstriction in anaesthetized guinea-pig model Intratracheal instillation 1.45 nM/kg Single administration, effects evaluated at 3 and 24 hours To evaluate the inhibitory effect of ipratropium on ACh-induced bronchoconstriction and its duration. Results showed that the inhibitory effect of ipratropium was short-lasting, with 28.3% inhibition at 3 hours and 14.2% at 24 hours. Br J Pharmacol. 2006 Jun;148(3):291-8.

Ipratropium bromide/异丙托溴铵 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03405090 Chronic Obstructive Pulmonary ... 展开 >>Disease 收起 << Phase 4 Recruiting August 2019 Canada, Ontario ... 展开 >> Respiratory Investigation Unit Recruiting Kingston, Ontario, Canada, K7L 2V7 Contact: Megha Ibrahim Masthan, MSc    613-549-6666 ext 4314    mim5@queensu.ca    Contact: Sandra Vincent    613-549-6666 ext 4890    vincents@queensu.ca    Principal Investigator: Denis E O'Donnell, MD, FRCPC 收起 <<
NCT00498251 Lung Injury, Acute ... 展开 >> Thoracotomy Anesthesia Intensive Care, Surgical Extravascular Lung Water 收起 << Not Applicable Completed - Switzerland ... 展开 >> University Hospital of Geneva Geneva, Switzerland, CH-1211 收起 <<
NCT01395875 - Completed - -

Ipratropium bromide/异丙托溴铵 参考文献

[1]Zhang W, et al. Eur J Pharmacol,?010, 647(1-3), 178-187.

[2]Shaik N, et al. Cell Physiol Biochem,?012, 30(6), 1517-1525.

[3]MacGregor TR, ZuWallack R, Rubano V, Castles MA, Dewberry H, Ghafouri M, Wood CC. Efficiency of Ipratropium Bromide and Albuterol Deposition in the Lung Delivered via a Soft Mist Inhaler or Chlorofluorocarbon Metered-Dose Inhaler. Clin Transl Sci. 2016 Apr;9(2):105-13.

[4]Schilero GJ, Hobson JC, Singh K, Spungen AM, Bauman WA, Radulovic M. Bronchodilator effects of ipratropium bromide and albuterol sulfate among subjects with tetraplegia. J Spinal Cord Med. 2018 Jan;41(1):42-47.

[5]Wang F, Zheng H, Zhang Y, Zhu H, Shi J, Luo Y, Zhang X, Mao H, Herth FJF, Luo F. Nebulized Ipratropium bromide protects against tracheal and bronchial secretion during bronchoscopy: A randomized controlled trial. Medicine (Baltimore). 2019 Nov;98(47):e17942.

Ipratropium bromide/异丙托溴铵 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.43mL

0.49mL

0.24mL

12.13mL

2.43mL

1.21mL

24.25mL

4.85mL

2.43mL

Ipratropium bromide/异丙托溴铵 技术信息

CAS号22254-24-6
分子式C20H30BrNO3
分子量 412.36
SMILES Code CC([N@@+]1([C@H]2C[C@@H](C[C@@H]1CC2)OC(C(C3=CC=CC=C3)CO)=O)C)C.[Br-]
MDL No. MFCD00069291
别名 Sch 1000; Ipratropium (bromide)
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, room temperature
溶解方案

DMSO: 35 mg/mL(84.88 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(242.51 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Ipratropium | 22254-24-6 | Sch 1000 | Sch1000 | Sch-1000 | mAChR Antagonist | GPCR/G Protein | Neuronal Signaling | mAChR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Ipratropium bromide/异丙托溴铵 纯度/质量文件 | Ipratropium bromide/异丙托溴铵 亚型比较 | Ipratropium bromide/异丙托溴铵 生物活性 | Ipratropium bromide/异丙托溴铵 临床数据 | Ipratropium bromide/异丙托溴铵 参考文献 | Ipratropium bromide/异丙托溴铵 实验方案 | Ipratropium bromide/异丙托溴铵 技术信息

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