Coclaurine, a natural product isolated and purified from the root of Coptis chinensis Franch, blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum.

Clozapine-d8是Clozapine的氘代同位素化合物。Clozapine 是一种抗精神病药物，具有高效结合多种神经受体的能力，广泛用于精神分裂症的研究。

nAChR agonist 1 is a novel positive allosteric modulator of α7 nAChR. It has shown excellent safety profile in phase 1 clinical trials and is being evaluated for efficacy and safety as monotherapy in patients with mild to moderate Alzheimer’s disease.

Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.

EVP-6124 is a partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) and shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs.

N-Methylcytisine's nicotinic receptors have high affinity (KD = 50 nM)to nAChR from squid optical ganglia.

Arecoline是一种天然生物碱，是烟碱和毒蕈碱乙酰胆碱受体的部分激动剂，具有刺激、警觉、抗焦虑和抗寄生虫的作用，同时也可诱导氧化应激。

Arecaidine but-2-ynyl ester tosylate is a potent muscarinic agonist that shows 4.6-fold that is selectivity for mAChR M2 in the atrium versus those in the ileum.

VU0152100 is a potent and selective allosteric potentiator of M4 mAChR.

Mepenzolate bromide mAchR antagonist, working as a post-ganglionic parasympathetic inhibitor to decrease gastric acid and pepsin secretion and suppresse spontaneous contractions of the colon.

Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell.

Cisatracurium besylate is an antagonize of AchR and inhibits neuromuscular transmission, a nondepolarizing skeletal muscle relaxant.

Nitenpyram is a nAchR agonist, used an antiparasitic drug.

Vecuronium bromide is a competitive AchR inhibitor and binds to cholinergic receptors at neuromuscular junctions, used as an aminosteroidal neuromuscular blocking agent.

Vinblastine Sulfate is a natural product targeting on microtubule formation, and also inhibits nAChR with IC50 value of 8.9 μM.

Rivastigmine tartrate is an AchR inhibitor use for treatment of mild to moderate Alzheimer's disease and Parkinson's disease with elimination half-life of ‎1.5 hours.

Dinotefuran is the third generation of neonicotinoid group,which works through inhibiting nAchRs.

Methylbenactyzium Bromide is a mAchR antagonist, used as a spasmolytic for the treatment of gastrointestinal ulcer and gastrointestinal spasms.

Pirenzepine 2HCl is a is an anticholinergic agent and induces the dimerization of muscarinic M1 receptors, used to treat myopia, gastric and duodenal ulcers.

Imidafenacin is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM and less potent for M2 receptors (IC50=4.13 nM).