Fasudil | AT877 | RhoA/ROCK Inhibitor | AmBeed-信号通路专用抑制剂

首页 / / / / Fasudil/法舒地尔

Fasudil/法舒地尔 {[allProObj[0].p_purity_real_show]}

货号：A702414 同义名： AT877; HA-1077

Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.

Fasudil/法舒地尔化学结构
CAS号：103745-39-7

Fasudil/法舒地尔 3D分子结构
CAS号：103745-39-7

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]} {[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]} {[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]}	现货	1周咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

Fasudil/法舒地尔纯度/质量文件产品仅供科研

货号：A702414 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

PKA 亚型比较
PKC 亚型比较
ROCK 亚型比较
转化生长因子-β 亚型比较
Calcium Channel 亚型比较
自噬亚型比较

产品名称	PKA ↓ ↑	其他靶点	纯度
Daphnetin	+ PKA, IC50: 9.33 μM	PKC,EGFR	95%
AT13148	++++ PKA, IC50: 3 nM		95%
A-674563 HCl	+++ PKA, Ki: 16 nM		99%
H-89 2HCl	++ PKA, Ki: 48 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	PKC ↓ ↑	PKCα ↓ ↑	PKCβ ↓ ↑	PKCγ ↓ ↑	PKCδ ↓ ↑	PKCε ↓ ↑	PKCζ ↓ ↑	PKCη ↓ ↑	PKCθ ↓ ↑	其他靶点	纯度
Daphnetin	+ PKC, IC50: 25.01 μM									PKA,EGFR	95%
Dequalinium Chloride											99%+
Quercetin	✔									Sirtuin,Src	95%
Myricetrin		✔									96%
Go 6983		+++ PKCα, IC50: 7 nM	+++ PKCβ, IC50: 7 nM	+++ PKCγ, IC50: 6 nM	+++ PKCδ, IC50: 10 nM		++ PKCζ, IC50: 60 nM				99%+
Go6976	+++ PKC, IC50: 7.9 nM	++++ PKCα, IC50: 2.3 nM	+++ PKCβ1, IC50: 6.2 nM							FLT3	99%+
Bisindolylmaleimide I		+++ PKCα, IC50: 20 nM	+++ PKCβ2, IC50: 16 nM PKCβ1, IC50: 17 nM	+++ PKCγ, IC50: 20 nM							99%+
Lawsone methyl ether			✔								99%
Sotrastaurin		++++ PKCα, Ki: 0.95 nM	++++ PKCβ1, Ki: 0.64 nM		++++ PKCδ, Ki: 2.1 nM	++++ PKCε, Ki: 3.2 nM		++++ PKCη, Ki: 1.8 nM	++++ PKCθ, Ki: 0.22 nM		99%+
Enzastaurin		++ PKCα, IC50: 39 nM	+++ PKCβ, IC50: 6 nM	+ PKCγ, IC50: 83 nM		+ PKCε, IC50: 110 nM					98%
Midostaurin		++ PKCα, IC50: 22 nM	++ PKCβ2, IC50: 31 nM PKCβ1, IC50: 30 nM	++ PKCγ, IC50: 24 nM	+ PKCδ, IC50: 330 nM	+ PKCε, IC50: 1.25 μM		+ PKCη, IC50: 160 nM			99%
Ro 31-8220 mesylate		++++ PKCα, IC50: 5 nM	+++ PKCβ2, IC50: 14 nM PKCβ1, IC50: 24 nM	++ PKCγ, IC50: 27 nM		++ PKCε, IC50: 24 nM					99%+
Staurosporine		++++ PKCα, IC50: 2 nM		++++ PKCγ, IC50: 5 nM	+++ PKCδ, IC50: 20 nM	++ PKCε, IC50: 73 nM		++++ PKCη, IC50: 4 nM			99%+
Ruboxistaurin HCl		+ PKCα, IC50: 0.36 μM	++++ PKCβ2, IC50: 5.9 nM PKCβ1, IC50: 4.7 nM	+ PKCγ, IC50: 0.3 μM	+ PKCδ, IC50: 0.25 μM			++ PKCη, IC50: 0.052 μM			99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	ROCK ↓ ↑	ROCK1 ↓ ↑	ROCK2 ↓ ↑	其他靶点	纯度
Thiazovivin	+ ROCK, IC50: ~0.5 μM				98%
Netarsudil HCl	++++ ROCK, Ki: 2 nM				99%+
Y-33075 2HCl	++++ ROCK, IC50: 3.6 nM				99%+
ROCK1-IN-1	++ ROCK, Ki: 17nM				95%
GSK429286A		+++ ROCK1, IC50: 14 nM	++ ROCK2, IC50: 63 nM		99%+
Ripasudil		++ ROCK1, IC50: 51 nM	++ ROCK2, IC50: 19 nM		99%+
Belumosudil			++ ROCK2, Ki: 41 nM ROCK2, IC50: 60 nM		99%+
Y-27632 2HCl		++ ROCK1, Ki: 140 nM	+ ROCK2, Ki: 300 nM		99%+
Fasudil HCl			+ ROCK2, Ki: 330 nM	Rho,PKG	98%
Chroman 1		++++ ROCK1, IC50: 52 pM	++++ ROCK2, IC50: 1 pM		99%
BAY-549		++++ ROCK1, IC50: 0.6 nM	++++ ROCK2, IC50: 1.1 nM		99%+
AT13148		+++ ROCK1, IC50: 6 nM	+++ ROCK2, IC50: 4 nM	PKA	95%
RKI-1447		+++ ROCK1, IC50: 14.5 nM	+++ ROCK2, IC50: 6.2 nM		99%+
Hydroxyfasudil HCl		+ ROCK1, IC50: 0.73 μM	+ ROCK2, IC50: 0.72 μM	PKA	98%
H-1152 2HCl			+++ ROCK2, IC50: 0.0120 μM	PKG	99%
GSK269962A HCl		++++ ROCK1, IC50: 1.6 nM	+++ ROCK2, IC50: 4 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	ALK1 ↓ ↑	ALK2 ↓ ↑	ALK3 ↓ ↑	ALK4 ↓ ↑	ALK6 ↓ ↑	Smad3 ↓ ↑	TGF-β ↓ ↑	TGFβRI/ALK5 ↓ ↑	TGFβRII ↓ ↑	纯度
LDN193189	++++ ALK1, IC50: 0.8 nM	++++ ALK2, IC50: 0.8 nM	+++ ALK3, IC50: 5.3 nM		+++ ALK6, IC50: 16.7 nM					99%+
LDN-212854	++++ ALK1, IC50: 2.4 nM	++++ ALK2, IC50: 1.3 nM	+ ALK3, IC50: 85.8 nM	+ ALK4, IC50: 2133 nM				+ ALK5, IC50: 9276 nM		99%+
ML347	++ ALK1, IC50: 46 nM	++ ALK2, IC50: 32 nM								98%
K02288	++++ ALK1, IC50: 1.8 nM	++++ ALK2, IC50: 1.1 nM	++ ALK3, IC50: 34.4 nM		+++ ALK6, IC50: 6.4 nM					99%+
LDN-193189 2HCl	++++ ALK1, IC50: 0.8 nM	++++ ALK2, IC50: 0.8 nM	+++ ALK3, IC50: 5.3 nM		+++ ALK6, IC50: 16.7 nM					99%
LDN-214117		++ ALK2, IC50: 24 nM								98%
DMH-1		+ ALK2, IC50: 107.9 nM								99%+
SB-505124				+ ALK4, IC50: 129 nM				++ ALK5, IC50: 47 nM		99%+
Vactosertib				+++ ALK4, IC50: 13 nM				+++ ALK5, IC50: 11 nM		99%+
Alantolactone						✔				98%
(E/Z)-SIS3 free base						✔				97%
Pirfenidone							✔			98%
Hesperetin							✔			97%
RepSox								++++ TGFβR1(ALK5), IC50: 4 nM		98%
GW788388								+++ ALK5, IC50: 18 nM		98%
LY364947								++ TGFβRI, IC50: 59 nM	+ TGFβRII, IC50: 0.4 μM	98%
SD-208								++ TGF-βRI (ALK5), IC50: 48 nM		99%
SB-525334								+++ TGFβR1(ALK5), IC50: 14.3 nM		99%+
LY2109761								++ TβRI, Ki: 38 nM	+ TβRII, Ki: 300 nM	99%+
Galunisertib								++ TβRI, IC50: 56 nM		98%
SB 431542								+ ALK5, IC50: 94 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	Ca2+ channel-like protein ↓ ↑	Calcium Channel ↓ ↑	Cav 2.2 ↓ ↑	其他靶点	纯度
CDC25B-IN-2	✔			Akt	99%+
Clevidipine		✔			97%
Verapamil HCl		✔			99%
Amlodipine		✔			99%
Amlodipine maleate		✔			98%
(+)-cis-Diltiazem HCl		✔			99%
Zegocractin		++ Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM			99%+
Tanshinone IIA sulfonate sodium		✔			98%
Ulixacaltamide		++ hCaV3.2, IC50: 110 nM hCaV3.1, IC50: 50 nM			99%+
Dronedarone HCl		✔			95%
Nitrendipine		+ Calcium channel, IC50: 95 nM			98%
Efonidipine HCl monoethanolate		✔			98%
Cinnarizine		✔			98%
SEA0400		++ NCX, IC50: 33 nM		ERK,ROS,p38 MAPK	99%+
Fasudil HCl		✔		PKA,Rho	98%
ML-9		✔		Akt,MLCK	99%+
Flunarizine 2HCl		+ Calcium channel, Ki: 68 nM			95%
Lomerizine 2HCl		✔			98%
Efonidipine		✔			98%
Levamlodipine		✔			98%
Nisoldipine		++ L-type Cav1.2, IC50: 10 nM			97%
Isradipine		✔			98%
Lacidipine		✔			98%
Lercanidipine		✔			99%
Loureirin B		✔		Potassium Channel	99%+
Tetracaine HCl		✔			98%
Manidipine		+++ Calcium channel, IC50: 2.6 nM			99%
Manidipine Dihydrochlorid		+++ Calcium channel, IC50: 2.6 nM			98%
Nicardipine		✔			99%
Wilforgine		✔			98+%
Econazole		✔			99%+
Ginsenoside Rd		✔		NF-κB	98%
Fendiline HCl		✔			98+%
Mesaconitine		✔			98%
Tetrandrine		✔			95%
Nifedipine		✔			98%
Nilvadipine		++++ Calcium channel, IC50: 0.03 nM			95%
Barnidipine		++++ [³H]nitrendipine, Ki: 0.21 nM			95+%
Azelnidipine		✔			97%
Levetiracetam		✔			98%
Nimodipine		✔			95%
Benidipine HCl		✔			98%
Pinaverium bromide		✔			98%
Pranidipine		✔			99%
NP118809		+ N-type Ca2+ channel, IC50: 0.11 μM L-type calcium channel, IC50: 12.2 μM			95%
Amlodipine Besylate		+++ Calcium channel, IC50: 1.9 nM			97%
Cilnidipine		✔			99%
Cinepazide Maleate		✔			99% (HPLC)
Terfenadine		✔			98%
YM-58483		✔			99%+
Amiloride HCl		✔			98%
Ranolazine		✔			98%
Praeruptorin A		✔		Akt,p38 MAPK	98%
Ranolazine 2HCl		✔			98%
Felodipine		++++ L-type calcium channel, IC50: 0.15 nM			98%
PD173212		+++ N-type Ca2+ channel, IC50: 36 nM			98%
Levamlodipine besylate		✔			97%
Carboxyamidotriazole Orotate		✔			98%
IGS-1.76		✔			98+%
WH-4-023		++++ Cav 2.2, IC50: 0.001 μM	++++ Cav 2.2, IC50: 0.001 μM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	Autophagy ↓ ↑	其他靶点	纯度
SBI-0206965	+++ ULK1, IC50: 108 nM ULK2, IC50: 711 nM		95%
Hydroxychloroquine sulfate	✔		99%
Valproic acid sodium	✔	HDAC	97%
PFK-015	++ PFKFB3, IC50: 207 nM		99%+
MRT68921 HCl	++++ ULK1, IC50: 2.9 nM ULK2, IC50: 1.1 nM		99%+
ROC-325	✔		99%+
Autophinib	+++ Autophagy, IC50: 40 nM		99%
Lys05	✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Fasudil/法舒地尔生物活性

描述	Fasudil hydrochloride is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.

Fasudil/法舒地尔动物实验

Species Mice	Animal Model Krit1+/− and Ccm2+/− mice	Administration	Dosage	Frequency	Description	References
Mice	Krit1+/− and Ccm2+/− mice	Intravenous administration	20 µg/kg	Single dose, evaluated after 30 minutes	Inhibited ROCK activity, reversed vascular leak and organ edema in Krit1+/? and Ccm2+/? mice	J Exp Med. 2010 Apr 12;207(4):881-96

Fasudil/法舒地尔临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01069042	Heart Failure	Phase 4	Unknown	November 2010	Taiwan ... 展开 >> National Cheng Kung University Hospital Recruiting Tainan, Taiwan, 70401 Contact: Ping-Yen Liu, MD, PhD 收起 <<
NCT03404843	Cardiovascular Diseases	Phase 2	Completed	-	United States, Colorado ... 展开 >> Colorado State University, Dept. of Health and Exercise Science Fort Collins, Colorado, United States, 80523 收起 <<
NCT01823081	Diabetic Macular Edema	Phase 3	Completed	-	Iran, Islamic Republic of ... 展开 >> Tehran, Iran, Islamic Republic of 收起 <<

Fasudil/法舒地尔参考文献

[1]Zhang J, Li XX, et al. Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. Clin Chim Acta. 2009 Mar;401(1-2):76-80.

[2]Ono-Saito N, Niki I, et al. H-series protein kinase inhibitors and potential clinical applications. Pharmacol Ther. 1999 May-Jun;82(2-3):123-31.

Fasudil/法舒地尔实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.43mL

0.69mL

0.34mL

17.16mL

3.43mL

1.72mL

34.32mL

6.86mL

3.43mL

Fasudil/法舒地尔技术信息

CAS号	103745-39-7
分子式	C₁₄H₁₇N₃O₂S
分子量	291.37
SMILES Code	O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O
MDL No.	MFCD00866182

别名	AT877; HA-1077
运输	蓝冰

存储条件	In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

Fasudil/法舒地尔 {[allProObj[0].p_purity_real_show]}

Fasudil/法舒地尔纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Fasudil/法舒地尔质控信息

Fasudil/法舒地尔生物活性

Fasudil/法舒地尔动物实验

Fasudil/法舒地尔临床研究

Fasudil/法舒地尔参考文献

Fasudil/法舒地尔实验方案

Fasudil/法舒地尔技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Fasudil/法舒地尔 {[allProObj[0].p_purity_real_show]}

Fasudil/法舒地尔 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Fasudil/法舒地尔 质控信息

Fasudil/法舒地尔 生物活性

Fasudil/法舒地尔 动物实验

Fasudil/法舒地尔 临床研究

Fasudil/法舒地尔 参考文献

Fasudil/法舒地尔 实验方案

Fasudil/法舒地尔 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Fasudil/法舒地尔纯度/质量文件产品仅供科研

Fasudil/法舒地尔质控信息

Fasudil/法舒地尔生物活性

Fasudil/法舒地尔动物实验

Fasudil/法舒地尔临床研究

Fasudil/法舒地尔参考文献

Fasudil/法舒地尔实验方案

Fasudil/法舒地尔技术信息