Thiazovivin (GMP) is produced in accordance with GMP guidelines. GMP-compliant small molecules are effective as auxiliary reagents in the manufacture of cell therapies. Thiazovivin is recognized as a potent ROCK inhibitor[1].
体外研究
Thiazovivin, a ROCK inhibitor, at 2 μM, suppresses ROCK activity and enhances the survival of human embryonic stem cells (hESCs) post-dissociation without compromising their pluripotency. It strengthens cell-ECM adhesion via integrin signaling and stabilizes E-cadherin after cell dissociation, thereby protecting hESCs from death in ECM-free conditions[1].
Thiazovivin enhances the attachment and primary colony formation of embryo-derived stem-like cells (eSLCs) from cattle on feeder layers. It promotes colony outgrowth and facilitates the expansion of eSLC cultures during subculturing for passaging. Additionally, Thiazovivin increases the expression of ectodermal lineage-specific genes in cattle eSLCs[2].
Thiazovivin (GMP) (0.5 μM, at 1 day) effectively facilitates the rapid reprogramming of mouse tail tip and embryonic fibroblasts into iPSCs[1].
Thiazovivin (GMP) improves the efficiency of reprogramming endometrial adult stromal cells into iPSCs[2].
Thiazovivin (GMP) at 2 μM induces the formation of iPSCs and induced neural stem cells (iNSCs) from human urine cells (UCs)[3].
Thiazovivin (GMP) (2 μM, for the first 24 h) enhances the growth rate of hiPSCs[4].
Thiazovivin (GMP) at 0.5 μM, in combination with SB431542 and PD0325901, enhances iPSC reprogramming by regulating cell-cell interactions[5].
Thiazovivin 细胞研究
细胞系
浓度
检测类型
检测时间
活性说明
数据源
HSMCs
1 μM
Function Assay
2 h
reverses AngII-induced MYPT1 phosphorylation
24965170
SCU-i10 hiPSCs
0-20 μM
Growth Inhibition Assay
24 h
significantly modulates single-cell plating efficiency and promote NCM growth
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