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/ Calcium Channel / Pinaverium bromide/匹维溴铵

Pinaverium bromide/匹维溴铵 {[allProObj[0].p_purity_real_show]}

货号：A217245 同义名： Icosapentaenoic acid

Pinaverium bromide作为钙通道阻滞剂，有助于恢复肠道的正常收缩过程。

Pinaverium bromide/匹维溴铵 化学结构 CAS号：53251-94-8
Pinaverium bromide/匹维溴铵 化学结构
CAS号：53251-94-8
Pinaverium bromide/匹维溴铵 3D分子结构
CAS号：53251-94-8
Pinaverium bromide/匹维溴铵 化学结构 CAS号：53251-94-8
Pinaverium bromide/匹维溴铵 3D分子结构 CAS号：53251-94-8
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Pinaverium bromide/匹维溴铵 纯度/质量文件 产品仅供科研

货号：A217245 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >
产品名称 Ca2+ channel-like protein ↓ Calcium Channel ↓ Cav 2.2 ↓ 其他靶点 纯度
CDC25B-IN-2 ✔ Akt 99%+
Clevidipine ✔ 97%
Verapamil HCl ✔ 99%
Amlodipine ✔ 99%
Amlodipine maleate ✔ 98%
(+)-cis-Diltiazem HCl ✔ 99%
Zegocractin ++

Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM

 		99%+
Tanshinone IIA sulfonate sodium ✔ 98%
Ulixacaltamide ++

hCaV3.1, IC50: 50 nM

hCaV3.2, IC50: 110 nM

 		99%+
Dronedarone HCl ✔ 95%
Nitrendipine +

Calcium channel, IC50: 95 nM

 		98%
Efonidipine HCl monoethanolate ✔ 98%
Cinnarizine ✔ 98%
SEA0400 ++

NCX, IC50: 33 nM

 		ERK,ROS,p38 MAPK 99%+
Fasudil HCl ✔ Rho,PKA 98%
ML-9 ✔ MLCK,Akt 99%+
Flunarizine 2HCl +

Calcium channel, Ki: 68 nM

 		95%
Lomerizine 2HCl ✔ 98%
Efonidipine ✔ 98%
Levamlodipine ✔ 98%
Nisoldipine ++

L-type Cav1.2, IC50: 10 nM

 		97%
Isradipine ✔ 98%
Lacidipine ✔ 98%
Lercanidipine ✔ 99%
Loureirin B ✔ Potassium Channel 99%+
Tetracaine HCl ✔ 98%
Manidipine +++

Calcium channel, IC50: 2.6 nM

 		99%
Manidipine Dihydrochlorid +++

Calcium channel, IC50: 2.6 nM

 		98%
Nicardipine ✔ 99%
Wilforgine ✔ 98+%
Econazole ✔ 99%+
Ginsenoside Rd ✔ NF-κB 98%
Fendiline HCl ✔ 98+%
Mesaconitine ✔ 98%
Tetrandrine ✔ 95%
Nifedipine ✔ 98%
Nilvadipine ++++

Calcium channel, IC50: 0.03 nM

 		95%
Barnidipine ++++

[3H]nitrendipine, Ki: 0.21 nM

 		95+%
Azelnidipine ✔ 97%
Levetiracetam ✔ 98%
Nimodipine ✔ 95%
Benidipine HCl ✔ 98%
Pinaverium bromide ✔ 98%
Pranidipine ✔ 99%
NP118809 +

L-type calcium channel, IC50: 12.2 μM

N-type Ca2+ channel, IC50: 0.11 μM

 		95%
Amlodipine Besylate +++

Calcium channel, IC50: 1.9 nM

 		97%
Cilnidipine ✔ 99%
Cinepazide Maleate ✔ 99% (HPLC)
Terfenadine ✔ 98%
YM-58483 ✔ 99%+
Amiloride HCl ✔ 98%
Ranolazine ✔ 98%
Praeruptorin A ✔ Akt,p38 MAPK 98%
Ranolazine 2HCl ✔ 98%
Felodipine ++++

L-type calcium channel, IC50: 0.15 nM

 		98%
PD173212 +++

N-type Ca2+ channel, IC50: 36 nM

 		98%
Levamlodipine besylate ✔ 97%
Carboxyamidotriazole Orotate ✔ 98%
IGS-1.76 ✔ 98+%
WH-4-023 ++++

Cav 2.2, IC50: 0.001 μM

 		++++

Cav 2.2, IC50: 0.001 μM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Pinaverium bromide/匹维溴铵 生物活性

靶点

  • Calcium Channel
描述 Pinaverium bromide acts as a calcium channel blocker in helping to restore the normal contraction process of the bowel.

Pinaverium bromide/匹维溴铵 细胞实验

Cell Line
Concentration Treated Time Description References
Rat colonic smooth muscle cells 0.1 – 10 µM 20 minutes To investigate the inhibitory effect of pinaverium on ACh or KCl-induced [Ca2+]i increment, results showed pinaverium inhibited [Ca2+]i increment in a dose-dependent manner. World J Gastroenterol. 2003 Mar;9(3):557-61
Human hepatocellular carcinoma cells HepG2 and Huh7 <50 µM 24 hours Pinaverium bromide significantly inhibited cell viability at high concentrations (50 or 100 μM). ACS Omega. 2023 Mar 6;8(10):9652-9661
Staphylococcus aureus CHS101 isolate 50 µM 24 hours Pinaverium bromide significantly inhibited the growth of planktonic cells and biofilm formation of S. aureus CHS101 isolate. ACS Omega. 2023 Mar 6;8(10):9652-9661
Rabbit jejunum longitudinal smooth muscle cells 1-100 µM 5 minutes To study the inhibitory effect of pinaverium on voltage-dependent inward current, with an IC50 of 1.5 μM, similar to verapamil, diltiazem, and flunarizine. Occasionally, a potentiating effect on inward current was observed. Br J Pharmacol. 1990 Feb;99(2):374-8

Pinaverium bromide/匹维溴铵 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Male Wistar rats Cold-restraint stress model In vitro tissue bath 100 nM - 30 µM Single administration, at least 15 min equilibration for each concentration To investigate the effect of pinaverium on stress-induced colonic smooth muscle contractility disorder, results showed pinaverium inhibited ACh or KCl-induced muscle contraction in a dose-dependent manner. World J Gastroenterol. 2003 Mar;9(3):557-61
Wistar rats Diarrhoea model Gavage 13.5 mg/kg Once daily for 7 consecutive days To evaluate the protective effect of Pinaverium Bromide on diarrhoea rats, results showed that Pinaverium Bromide significantly improved diarrhoea symptoms. Pharm Biol. 2021 Dec;59(1):1452-1463
Rats Rat isolated colon model Organ bath administration 3.4 μM (BaCl2 stimulation), 5.2μM (acetylcholine stimulation), 3.3μM (FK33-824 stimulation) Single administration To investigate the effect of Pinaverium bromide on the motility of rat isolated colon, results showed that it reduces calcium influx by inhibiting calcium channels, producing a spasmolytic effect, and its effect is 30 times weaker than verapamil Br J Pharmacol. 1985 Sep;86(1):89-94
Sprague-Dawley rats Chronic visceral hypersensitivity model Intragastric administration 5 mg/mL Once daily for 7 consecutive days Pinaverium bromide significantly decreased abdominal withdrawal reflex scores in rats with chronic visceral hypersensitivity and significantly reduced P2X4 receptor immunoreactivity in the colon and spinal cord. Neural Regen Res. 2013 Aug 5;8(22):2069-77

Pinaverium bromide/匹维溴铵 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01641224 Irritable Bowel Syndrome Not Applicable Unknown May 2014 China, Jiangsu ... 展开 >> Second Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu, China, 210017 Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu, China, 210029 China Beijing Xuanwu Hospital of Traditional Chinese Medicine affiliated to Capital Medical University. Beijing, China, 100050 Shanghai First People's Hospital affiliated to Shanghai Tiao Tong University Shanghai, China, 200240 收起 <<
NCT02330029 Irritable Bowel Syndrome Not Applicable Unknown May 2017 China, Jiangsu ... 展开 >> Second Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu, China, 210017 Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu, China, 210029 China Beijing Xuanwu Hospital of Traditional Chinese Medicine affiliated to Capital Medical University. Beijing, China, 100050 Shanghai First People's Hospital affiliated to Shanghai Tiao Tong University Shanghai, China, 200240 收起 <<
NCT01678781 - Completed - China ... 展开 >> Site reference ID/Investigator# 94519 Beijing, China, 100034 Site reference ID/Investigator# 95475 Guangzhou City, China, 510515 Site reference ID/Investigator# 94521 Guangzhou, China, 510080 Site reference ID/Investigator # 94518 Shanghai, China, 200127 Site reference ID/Investigator # 94517 Shanghai, China, 200433 Site reference ID/Investigator # 94516 Shanghai, China Site reference ID/Investigator # 94515 Wuhan, China, 430022 Egypt Site Reference ID/Investigator# 95908 Alexandria, Egypt Site reference ID/Investigator# 95900 Cairo, Egypt Site reference ID/Investigator# 95901 El Sharkya, Egypt Site reference ID/Investigator# 95902 Giza, Egypt Site reference ID/Investigator# 95903 Giza, Egypt Site Reference ID/Investigator# 95906 Port Said, Egypt Mexico Site reference ID/Investigaot# 94525 Guadalajara, Mexico, 49000 Site refernce ID/Investigator# 94527 Mexico City, Mexico, 54055 Site reference ID/Investigator# 94523 Tampico, Mexico, 89190 Poland Site reference ID/Investigator# 85314 Bialystok, Poland, 15-270 Site Reference ID/Investigator# 85297 Bialystok, Poland, 15-351 Site Reference ID/Investigator# 85298 Bydgoszcz, Poland, 85-079 Site Reference ID/Investigator# 85293 Katowice, Poland, 40-031 Site Reference ID/Investigator# 85296 Lodz, Poland, 91-473 Site reference ID/Investigator# 85313 Olsztyn, Poland, 10-501 Site Reference ID/Investigator# 85295 Poznan, Poland, 60-193 Site Reference ID/Investigator# 85294 Poznan, Poland, 60-539 收起 <<

Pinaverium bromide/匹维溴铵 参考文献

[1]Dai Y, Liu JX, et al. Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World J Gastroenterol. 2003 Mar;9(3):557-61.

[2]Boyer JC, Magous R, et al. Contraction of human colonic circular smooth muscle cells is inhibited by the calcium channel blocker pinaverium bromide. Cell Calcium. 2001 Jun;29(6):429-38.

Pinaverium bromide/匹维溴铵 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.69mL

0.34mL

0.17mL

8.45mL

1.69mL

0.85mL

16.91mL

3.38mL

1.69mL

Pinaverium bromide/匹维溴铵 技术信息

CAS号53251-94-8
分子式C26H41Br2NO4
分子量 591.42
SMILES Code CC1(C)C2CCC(CCOCC[N+]3(CC4=CC(OC)=C(OC)C=C4Br)CCOCC3)C1C2.[Br-]
MDL No. MFCD01713435
别名 Icosapentaenoic acid
运输蓝冰
InChI Key IKGXLCMLVINENI-UHFFFAOYSA-M
Pubchem ID 40703
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, room temperature
溶解方案

DMSO: 50 mg/mL(84.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(16.91 mM)，配合低频超声，并水浴加热至45℃助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: Pinaverium | 53251-94-8 | Calcium Channel | Ca2+ channels | Calcium Channel Inhibitor | Membrane Transporter/Ion Channel | Neuronal Signaling | Calcium Channel | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Pinaverium bromide/匹维溴铵 纯度/质量文件 | Pinaverium bromide/匹维溴铵 亚型比较 | Pinaverium bromide/匹维溴铵 生物活性 | Pinaverium bromide/匹维溴铵 临床数据 | Pinaverium bromide/匹维溴铵 参考文献 | Pinaverium bromide/匹维溴铵 实验方案 | Pinaverium bromide/匹维溴铵 技术信息

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