Myricitrin, isolated from Daebong persimmon peel, is a major antioxidant flavonoid. Myricitrin had the strongest antioxidant activities by ferric ion reducing antioxidant power and α,α-diphenyl-2-picrylhydrazyl radical scavenging assays[3]. Myricitrin decreased the level of total serum cholesterol and the role of aortic atherosclerosis in hypercholesterolemic rats[4]. Myricitrin had the anti-diabetic and hepatoprotective effects on the aged mice induced by D-galactose[5]. Myricitrin ameliorated neuroinflammation and improved memory in rats with CLP(cecal ligation and puncture)-induced sepsis by regulating the NLRP3/Bax/Bcl signalling pathway[6]. Myricitrin blocks activation of protects NF-κB and MAPK signaling pathways to nigrostiatum neuron from injury in LPS-stimulated mice and is beneficial to treatment nigrostriatum inflammation of PD[7].
Myricetrin/杨梅苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Human gingival fibroblasts
10 μM
4 h
To study the effect of myricetin on LTA-induced COX-2 transcription and translation, it was found that myricetin significantly inhibited COX-2 expression.
Cell Mol Biol Lett. 2014 Mar;19(1):126-39.
Human gingival fibroblasts
10 μM
30 min
To evaluate the effects of myricetin on LTA-induced phosphorylation of ERK1/2, p38, and AKT, it was found that myricetin inhibited the activation of these kinases.
Cell Mol Biol Lett. 2014 Mar;19(1):126-39.
Normal pancreatic ductal cells
12.5–200µM
24 h
Myricetin had little effect on normal pancreatic ductal cell viability, except at the highest dose (200µM)
Cancer Lett. 2011 Sep 28;308(2):181-8.
S2-013 cells
12.5–200µM
24 h
Myricetin significantly reduced S2-013 cell viability in a dose-dependent manner
Cancer Lett. 2011 Sep 28;308(2):181-8.
Panc-1 cells
12.5–200µM
24 h
Myricetin significantly reduced Panc-1 cell viability in a dose-dependent manner
Cancer Lett. 2011 Sep 28;308(2):181-8.
MIA PaCa-2 cells
12.5–200µM
24 h
Myricetin significantly reduced MIA PaCa-2 cell viability in a dose-dependent manner
Cancer Lett. 2011 Sep 28;308(2):181-8.
Rat islet cells
20 μM
48 h
Myricetin significantly attenuated HG-induced apoptosis in isolated rat islets.
Diabetes Metab J. 2019 Apr;43(2):192-205.
INS-1 cells
20 μM
24 h
Myricetin protects INS-1 cells from HG-induced apoptosis by inhibiting ER stress, possibly through inactivation of CDK5 and consequent upregulation of PDX1 and SERCA2b.
Diabetes Metab J. 2019 Apr;43(2):192-205.
C4-2B cells
20.6 ± 0.9 μM
3 days
To evaluate the effect of myricetin on the growth of C4-2B cells, results showed that myricetin significantly reduced cell viability.
J Biomed Sci. 2022 May 9;29(1):29.
LNCaP cells
18.5 ± 0.8 μM
3 days
To evaluate the effect of myricetin on the growth of LNCaP cells, results showed that myricetin significantly reduced cell viability.
J Biomed Sci. 2022 May 9;29(1):29.
THP1 macrophages
100, 200, 400 μM
Evaluate the anti-inflammatory effect of Myricetin, results showed Myricetin significantly reduced the expression levels of RIPK1 and NF-κB.
Phytomedicine. 2023 Jul 25;116:154858.
Vero E6 cells
1.95 to 31.25 μM
72 h
Evaluate the inhibitory effect of Myricetin on SARS-CoV-2 replication, results showed EC50 of 55.18 μM.
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