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货号 产品名 纯度
A255643 现货 Belumosudil

Belumosudil (KD025) 是一种选择性 ROCK2 抑制剂,对 ROCK2IC50 值为 105 nM,对 ROCK1IC50 值为 24 µM,具有抗纤维化特性。

99%+
A204681 现货 Y-33075 2HCl/Y-39983盐酸

Y-33075 2HCl具有选择性作为 ROCK 抑制剂,IC50 为 3.6 nM。

99%+
A193859 现货 Fasudil HCl/盐酸法舒地尔

Fasudil HCl (HA-1077; AT877)是一种非特异性RhoA/ROCK抑制剂,同时抑制蛋白激酶,对ROCK1的Ki为0.33 μM,对ROCK2PKAPKCPKGIC50值分别为0.158 μM、4.58 μM、12.30 μM和1.650 μM。Fasudil盐酸盐还是一种强效的Ca2+通道拮抗剂和血管扩张剂。

98%
A1942326 现货 Zelasudil

98%
A511851 现货 LIMK-IN-1/化合物LIMK-IN-22J

95%
A105790 现货 GSK269962A HCl

GSK269962 HCl is a selective ROCK (Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

99%+
A168750 现货 BAY-549

ROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively.

98%+
A130094 现货 Ripasudil

K-115 HCl is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.

99%+
A225129 现货 Narciclasine/水仙环素

Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

99%+
A919821 现货 ROCK2-IN-2

ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM.

98%+
A1263609 现货 Netarsudil Mesylate

99%+
A617994 现货 RKI-1313

RKI-1313 is a negative control for RKI-1447 (GLXC-05200) which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.

99%+
A1549873 现货 RKI-1447 2HCl

98%+
A569516 现货 GSK429286A

GSK429286A selectively inhibits ROCK1 and ROCK2 with the IC50 value of 14 nM and 63 nM, respectively.

99%+
A303159 现货 SAR407899

SAR407899 is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively.

99%+
A317869 现货 RKI-1447

RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, and has anti-invasive and antitumor activities.

99%+
A1177078 现货 ROCK inhibitor-2

99%+
A1598869 现货 ROCK1-IN-1

95%
A1806913 现货 CAY10746

99%+
A2021568 现货 THK01

98%+
产品名 ROCK ROCK1 ROCK2 其他靶点 纯度
Thiazovivin +

ROCK, IC50: ~0.5 μM

98%
Netarsudil hydrochloride ++++

ROCK, Ki: 2 nM

99%+
Y-33075 2HCl ++++

ROCK, IC50: 3.6 nM

99%+
ROCK1-IN-1 ++

ROCK, Ki: 17nM

95%
GSK429286A +++

ROCK1, IC50: 14 nM

++

ROCK2, IC50: 63 nM

99%+
Ripasudil ++

ROCK1, IC50: 51 nM

++

ROCK2, IC50: 19 nM

99%+
Belumosudil ++

ROCK2, IC50: 60 nM

ROCK2, Ki: 41 nM

99%+
Y-27632 dihydrochloride ++

ROCK1, Ki: 140 nM

+

ROCK2, Ki: 300 nM

99%+
Fasudil HCl +

ROCK2, Ki: 330 nM

Rho,PKG 98%
Chroman 1 ++++

ROCK1, IC50: 52 pM

++++

ROCK2, IC50: 1 pM

99%
BAY-549 ++++

ROCK1, IC50: 0.6 nM

++++

ROCK2, IC50: 1.1 nM

98%+
AT13148 +++

ROCK1, IC50: 6 nM

+++

ROCK2, IC50: 4 nM

PKA 98+%
RKI-1447 +++

ROCK1, IC50: 14.5 nM

+++

ROCK2, IC50: 6.2 nM

99%+
Hydroxyfasudil HCl +

ROCK1, IC50: 0.73 μM

+

ROCK2, IC50: 0.72 μM

PKA 99%+
H-1152 2HCl +++

ROCK2, IC50: 0.0120 μM

PKG 99%
GSK269962A HCl ++++

ROCK1, IC50: 1.6 nM

+++

ROCK2, IC50: 4 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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