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/ Dehydrodiisoeugenol/脱氢二异丁香酚

Dehydrodiisoeugenol/脱氢二异丁香酚 {[allProObj[0].p_purity_real_show]}

货号：A1371141 同义名： 去氢二异丁香酚

Dehydrodiisoeugenol是一种天然产物，具有抗炎和抗菌活性，可抑制小鼠巨噬细胞 (含LPS刺激) 中 NF-κB 活化和环氧合酶 (COX)-2 基因的表达。

Dehydrodiisoeugenol/脱氢二异丁香酚 化学结构 CAS号：2680-81-1
Dehydrodiisoeugenol/脱氢二异丁香酚 化学结构
CAS号：2680-81-1
Dehydrodiisoeugenol/脱氢二异丁香酚 3D分子结构
CAS号：2680-81-1
Dehydrodiisoeugenol/脱氢二异丁香酚 化学结构 CAS号：2680-81-1
Dehydrodiisoeugenol/脱氢二异丁香酚 3D分子结构 CAS号：2680-81-1
规格 价格 会员价 库存 数量
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Dehydrodiisoeugenol/脱氢二异丁香酚 纯度/质量文件 产品仅供科研

货号：A1371141 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 NF-κB ↓ 其他靶点 纯度
Ammonium pyrrolidine-1-carbodithioate ✔ 98%
QNZ ++++

NF-κB, IC50: 11 nM

 		99%+
Sodium 4-Aminosalicylate Dihydrate ✔ 98%
Sodium Salicylate ✔ 95%
Parthenolide ✔ p53 97% HPLC
JSH-23 +

NF-κB, IC50: 7.1 μM

 		98%
Phenethyl caffeate ✔ 98%
Andrographolide ✔ 98+%
Curcumin ✔ HDAC,Nrf2 98%
SC75741 +++

NF-κB, EC50: 200 nM

 		99%+
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

 		p53 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 COX ↓ COX-1 ↓ COX-2 ↓ 其他靶点 纯度
Piroxicam ✔ 98%
Salicylic acid ✔ 98%
Phenacetin ✔ 98%
Etodolac ✔ 99%
Flunixin meglumine ✔ 98%
Ibuprofen L-lysine ✔ 98%
Nabumetone ✔ 98%
Acemetacin ✔ 98%
Diflunisal ✔ 98%
Pranoprofen ✔ 98%
Ampiroxicam ✔ 98%
Meloxicam ✔ 98%
Sulindac ✔ 98%
Ketoprofen ✔ 98%
Mefenamic Acid ✔ 95%
Bromfenac sodium ✔ 98%
Oxaprozin ✔ 99%
Aspirin ✔ 99%
Nepafenac ✔ 98%
Zaltoprofen ✔ 99%
Salicin ✔ 98%
Suprofen ✔ 99%+
Xanthohumol ✔ 99%
Parecoxib ✔ 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

 		98%
Etoricoxib ✔ 99%
Niflumic Acid ✔ 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

 		99+%
Ibuprofen +

COX-1, IC50: 13 μM

 		+

COX-2, IC50: 370 μM

 		98%
Indomethacin ++

COX1, IC50: 0.28 μM

 		+

COX-2, IC50: 14 μM

 		97%
Lornoxicam ++++

COX-1, IC50: 5 nM

 		++++

COX-2, IC50: 8 nM

 		98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

 		+++

COX-2, IC50: 50 nM

 		99%
Asaraldehyde ✔ 98%
Naproxen +

COX-1, IC50: 8.7 μM

 		+

COX-2, IC50: 5.2 μM

 		98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

 		+++

COX-2, IC50: 200 nM

 		98%
NS-398 ++

COX-2, IC50: 3.8 μM

 		95%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

 		+++

COX-2, IC50: 150 nM

 		98%+
Nimesulide +

COX-2, IC50: 26 μM

 		98%
Lumiracoxib ++

COX-1, Ki: 3 μM

 		+++

COX-2, Ki: 60 nM

 		98%
Rutaecarpine ✔ 95%
Celecoxib ++++

COX-2, IC50: 40 nM

 		98%
Carprofen ++++

canine COX2, IC50: 30 nM

 		98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

 		++

COX-2 (human), IC50: 3.50 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Dehydrodiisoeugenol/脱氢二异丁香酚 生物活性

描述 Dehydrodiisoeugenol, a natural product isolated and purified from the seeds of Myristica fragrans Houtt. with anti-inflammatory activity, inhibits LPS-stimulated expression of the COX-2 in RAW264.7 murine macrophages and phosphorylation-dependent proteolysis of inhibitor IκB-α and transcriptional activity of NF-κB in the cells, and can cross the blood-brain barrier rapidly and might be one of the main bioactive substances of nutmeg.

Dehydrodiisoeugenol/脱氢二异丁香酚 细胞实验

Cell Line
Concentration Treated Time Description References
MCF-10A 56.80 μM (IC50) 48 h No killing effect on normal breast epithelial cells Front Pharmacol. 2025 Feb 28;16:1545498
MCF-7 15.96 μM (IC50) 48 h Inhibited breast cancer cell proliferation by blocking the G0/G1 phase of the cell cycle Front Pharmacol. 2025 Feb 28;16:1545498
MDA-MB-231 14.98 μM (IC50) 48 h Inhibited breast cancer cell proliferation by blocking the G0/G1 phase of the cell cycle Front Pharmacol. 2025 Feb 28;16:1545498
NCM460 cells 0.001-1000 μM 48 h The IC50 of DEH on NCM460 cells was significantly higher than that on HCT 116 and SW620 cells, indicating lower toxicity to normal cells. J Exp Clin Cancer Res. 2021 Apr 10;40(1):125
SW620 cells 20, 40, 60 μM 48 h DEH significantly inhibited the proliferation and growth of SW620 cells by arresting the cell cycle at the G1/S phase. J Exp Clin Cancer Res. 2021 Apr 10;40(1):125
HCT 116 cells 20, 40, 60 μM 48 h DEH significantly inhibited the proliferation and growth of HCT 116 cells by arresting the cell cycle at the G1/S phase. J Exp Clin Cancer Res. 2021 Apr 10;40(1):125
NCM460 human normal intestinal epithelial cells 30 µM Evaluate the impact of DDIE on cell viability, results showed no cytotoxicity within the tested concentration range Acta Pharm Sin B. 2024 Dec;14(12):5286-5304

Dehydrodiisoeugenol/脱氢二异丁香酚 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c mice Subcutaneous tumor-bearing mouse model Intraperitoneal injection 40 mg/kg Administered every other day for 2 weeks DHIE significantly reduced tumor burden, decreased Ki-67 infiltration level, and inhibited PLK1 expression Front Pharmacol. 2025 Feb 28;16:1545498
NOD/SCID mice CDX and PDX tumor xenograft models Intraperitoneal injection 40 mg/kg Once every other day for two weeks DEH significantly inhibited tumor growth in CDX and PDX models without affecting mouse body weight, indicating low toxicity. J Exp Clin Cancer Res. 2021 Apr 10;40(1):125
BALB/c mice CPT11-induced gut mucositis model Oral gavage 25 and 75 mg/kg Once daily for 12 days (Days 3–14) Evaluate the protective effect of DDIE against CPT11-induced gut mucositis, results showed DDIE significantly alleviated weight loss, colon shortening, epithelial barrier dysfunction, goblet cells and intestinal stem cells (ISCs) loss, and promoted wound healing Acta Pharm Sin B. 2024 Dec;14(12):5286-5304

Dehydrodiisoeugenol/脱氢二异丁香酚 参考文献

[1]Zhang YB, Zhu LQ, Yang XW. Cerebral nuclei distribution study of dehydrodiisoeugenol as an anxiogenic agent determined by RP-HPLC. Fitoterapia. 2013 Jan;84:47-53.

[2]Li F, Yang XW. Analysis of anti-inflammatory dehydrodiisoeugenol and metabolites excreted in rat feces and urine using HPLC-UV. Biomed Chromatogr. 2012 Jun;26(6):703-7.

Dehydrodiisoeugenol/脱氢二异丁香酚 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.32mL

3.06mL

1.53mL

30.64mL

6.13mL

3.06mL

Dehydrodiisoeugenol/脱氢二异丁香酚 技术信息

CAS号2680-81-1
分子式C20H22O4
分子量 326.39
SMILES Code OC1=CC=C(C2OC3=C(OC)C=C(/C=C/C)C=C3C2C)C=C1OC
MDL No. N/A
别名 去氢二异丁香酚
运输蓝冰
InChI Key ITDOFWOJEDZPCF-AATRIKPKSA-N
Pubchem ID 5379033
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, 2-8°C
溶解方案

DMSO: 105 mg/mL(321.7 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: Dehydrodiisoeugenol | 2680-81-1 | COX Inhibitor | NF-κB | Immunology/Inflammation | Anti-infection | NF-κB | COX | Bacterial | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Dehydrodiisoeugenol/脱氢二异丁香酚 纯度/质量文件 | Dehydrodiisoeugenol/脱氢二异丁香酚 亚型比较 | Dehydrodiisoeugenol/脱氢二异丁香酚 生物活性 | Dehydrodiisoeugenol/脱氢二异丁香酚 参考文献 | Dehydrodiisoeugenol/脱氢二异丁香酚 实验方案 | Dehydrodiisoeugenol/脱氢二异丁香酚 技术信息

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