Diclofenac Sodium Salt

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Chemical Structure| 15307-79-6 同义名 : Diclofenac Sodium; GP 45840; Diclofenac(sodium salt); Diclofenac(Sodium)
CAS号 : 15307-79-6
货号 : A105695
分子式 : C14H10Cl2NNaO2
纯度 : 98%
分子量 : 318.13
MDL号 : MFCD00082251
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 10 mg/mL(31.43 mM)，配合低频超声，并水浴加热至45℃助溶
生物活性
靶点

  • COX-2

    COX-2, IC50:200 nM

  • COX-1

    COX-1, IC50:60 nM
描述 Diclofenac Sodium (GP 45840) is a potent, nonselective anti-inflammatory agent that functions as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1]. Diclofenac Sodium triggers apoptosis in neural stem cells (NSCs) by activating the caspase cascade[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.72mL

3.14mL

1.57mL

31.43mL

6.29mL

3.14mL
参考文献

[1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.

[2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.