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/ Clonidine HCl/盐酸可乐定

Clonidine HCl/盐酸可乐定 {[allProObj[0].p_purity_real_show]}

货号：A530479 同义名： Clonidine (hydrochloride); Kapvay

Clonidine HCl是一种中枢作用且可穿透大脑的 α2-肾上腺素受体激动剂，可以降低血压。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Clonidine HCl/盐酸可乐定 化学结构 CAS号：4205-91-8
Clonidine HCl/盐酸可乐定 化学结构
CAS号：4205-91-8
Clonidine HCl/盐酸可乐定 3D分子结构
CAS号：4205-91-8
Clonidine HCl/盐酸可乐定 化学结构 CAS号：4205-91-8
Clonidine HCl/盐酸可乐定 3D分子结构 CAS号：4205-91-8
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Clonidine HCl/盐酸可乐定 纯度/质量文件 产品仅供科研

货号：A530479 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Adrenergic Receptor ↓ α-adrenergic receptor ↓ β-adrenergic receptor ↓ 其他靶点 纯度
Ivabradine HCl ✔ 98%
Maprotiline HCl ✔ 98%
Cisatracurium besylate ✔ 96%
Yohimbine HCI ✔ 99+%
BMY 7378 ++

α1D-adrenoceptor, pKi: 5.1

α2C-adrenoceptor, pKi: 6.54

 		+

β1-adrenoceptor, pIC50: 5.1

 		97%
Asenapine maleate ++++

α2A-adrenergic receptor, pKi: 8.9

α2B-adrenergic receptor, pKi: 8.9

 		97%
Piribedil ++

adrenoceptor α2C, pKi: 7.2

adrenoceptor α2A, pKi: 7.1

 		98%
Prazosin HCl ✔ 95%
Silodosin ✔ 98%
Phenoxybenzamine HCl ✔ 98%
Labetalol HCl ✔ 98+%
Naftopidil +++

α1D-adrenergic receptor, Ki: 20 nM

α1A-adrenergic receptor, Ki: 3.7 nM

 		98%
Naftopidil 2HCl +

α1-adrenergic receptor, IC50: 0.2 μM

 		99%
Alfuzosin HCl ✔ 98%
Terazosin HCl ✔ 99%
Atipamezole ✔ 95%
Phentolamine methanesulfonate salt ✔ 99%
Carvedilol ✔ 98%
Doxazosin mesylate ✔ 99%
Tolazoline HCl ✔ 98%
Esmolol HCl ✔ 95%
Propranolol HCl ++

β-adrenergic receptor, IC50: 12 nM

 		98%
Zenidolol HCl ++++

β1-adrenergic receptor, Ki: 611nM

β2-adrenergic receptor, Ki: 0.7nM

 		98%
Acebutolol HCl ✔ 97+%
Carteolol HCl ✔ 98+%
Betaxolol ✔ 95%
Betaxolol HCl +

β1-adrenergic receptor, IC50: 6 μM

 		97%
Bisoprolol ✔ 97%
Sotalol HCl ✔ 95+%
Nebivolol HCl +++

β1-adrenoceptor, IC50: 0.8 nM

 		99%
Metoprolol ✔ 98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 Autophagy ↓ 其他靶点 纯度
SBI-0206965 +++

ULK2, IC50: 711 nM

ULK1, IC50: 108 nM

 		95%
Hydroxychloroquine sulfate ✔ 99%
Valproic acid sodium ✔ HDAC 97%
PFK-015 ++

PFKFB3, IC50: 207 nM

 		99%+
MRT68921 HCl ++++

ULK2, IC50: 1.1 nM

ULK1, IC50: 2.9 nM

 		99%+
ROC-325 ✔ 99%+
Autophinib +++

Autophagy, IC50: 40 nM

 		99%
Lys05 ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Clonidine HCl/盐酸可乐定 生物活性

描述 Clonidine hydrochloride is a potent antihypertensive agent. Clonidine, as an alpha-adrenergic receptor agonist, is one of the most versatile and effective agents presently available for the treatment of hypertension[3]. Clonidine could stimulate CGRP (calcitonin gene-related peptide) synthesis and secretion in endothelial cells through the activation of alpha(2)-adrenoceptor, which is related to the NO pathway[4]. Clonidine (0.003-0.1 mg/kg, i.p.) dose-dependently attenuated the ability of phencyclidine (2.5 mg/kg, i.p.) to increase cortical dopamine output[5].

Clonidine HCl/盐酸可乐定 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03174067 Opioid Withdrawal ... 展开 >> Opioid-use Disorder 收起 << Phase 4 Completed - -
NCT00312416 Ocular Physiology ... 展开 >> Regional Blood Flow 收起 << Phase 4 Completed - Austria ... 展开 >> Department of Clinical Pharmacology Vienna, Austria, 1090 收起 <<
NCT01205204 Full Term Pregnant Patients ... 展开 >> Undergoing Lower Segment Caesarian Section 收起 << Not Applicable Withdrawn(This study was regis... 展开 >>tered with Clinical Trials.gov by mistake.) 收起 << November 2011 -

Clonidine HCl/盐酸可乐定 参考文献

[1]Zhang YM, Peng J, et al. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30(9):1746-52.

[2]Ugajski J, Zacny E, et al. The involvement of central alpha-adrenergic and histamine H2-receptors in the hypothermia induced by clonidine in the rat. Neuropharmacology. 1980 Jan;19(1):9-15.

[3]Houston MC. Clonidine hydrochloride. South Med J. 1982 Jun;75(6):713-9.

[4]Zhang YM, Peng J, Hu CP, Jiang QT, Jiang GL, Li YJ. Clonidine induces calcitonin gene-related peptide expression via nitric oxide pathway in endothelial cells. Peptides. 2009 Sep;30(9):1746-52.

[5]Jentsch JD, Sanchez D, Elsworth JD, Roth RH. Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype. Brain Res. 2008 Dec 30;1246:41-6.

Clonidine HCl/盐酸可乐定 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.75mL

0.75mL

0.38mL

18.76mL

3.75mL

1.88mL

37.52mL

7.50mL

3.75mL

Clonidine HCl/盐酸可乐定 技术信息

CAS号4205-91-8
分子式C9H10Cl3N3
分子量 266.55
SMILES Code ClC1=C(NC2=NCCN2)C(Cl)=CC=C1.Cl
MDL No. MFCD00036705
别名 Clonidine (hydrochloride); Kapvay; Benzenamine, 2,6-dichloro-N-2-imidazolidinylidene-, monohydrochloride; 2-Imidazoline, 2-(2,6-dichloroanilino)-, monohydrochloride; ST 155; Clonidine hydrochloride
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C
溶解方案

DMSO: 6 mg/mL(22.51 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(112.55 mM)，配合低频超声助溶

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案一

Tags: Clonidine | 4205-91-8 | Adrenergic Receptor Agonist | GPCR/G Protein | Neuronal Signaling | Adrenergic Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Clonidine HCl/盐酸可乐定 纯度/质量文件 | Clonidine HCl/盐酸可乐定 亚型比较 | Clonidine HCl/盐酸可乐定 生物活性 | Clonidine HCl/盐酸可乐定 临床数据 | Clonidine HCl/盐酸可乐定 参考文献 | Clonidine HCl/盐酸可乐定 实验方案 | Clonidine HCl/盐酸可乐定 技术信息

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