There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Phenoxybenzamine hydrochloride is a selective antagonist of both α-adrenoceptor and calmodulin that is commonly used for the treatment of hypertension, specifically caused by pheochromocytoma. The IC50 (100 nM) derived from the blockade of [3H]yohimbine binding by phenoxybenzamine was significantly less than the IC50 (550 nM) for the corresponding reversal by phenoxybenzamine of the effects of norepinephrine on cyclic AMP accumulation[2]. Phenoxybenzamine hydrochloride (50 nM) in conbination with Phenoxybenzamine hydrochloridetolamine (1000 nM) enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with pretreatment with Phenoxybenzamine hydrochloride (50 nM) alone in endothelium-intact aortae. Combined treatment with either dexmedetomidine (300 or 1000 nM) and Phenoxybenzamine hydrochloride (50 nM) or Phenoxybenzamine hydrochloridetolamine (1000 nM) and Phenoxybenzamine hydrochloride (50 nM) enhance Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with Phenoxybenzamine hydrochloride alone (50 nM)[3]. PHEN (Phenoxybenzamine Hydrochloride) exhibited a significant inhibitory effect on the proliferation of both U251 and U87MG glioma cell lines in a positive dose-dependent manner. PHEN apparently attenuated the malignancy of glioma in terms of migration and invasion and also suppressed the tumorigenic capacity both in vitro and in vivo[4].
Phenoxybenzamine HCl/盐酸酚苄明 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Rat hippocampal slice cultures
0.1 µM–1 mM
24 hours
To evaluate the neuroprotective effect of Phenoxybenzamine under oxygen glucose deprivation (OGD) conditions. Results showed that Phenoxybenzamine significantly reduced neuronal death induced by OGD over a broad dose range (0.1 µM–1 mM).
Int J Mol Sci. 2014 Jan 20;15(1):1402-17
Phenoxybenzamine HCl/盐酸酚苄明 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Wistar rats
Lateral fluid percussion (LFP) model of severe traumatic brain injury
Intravenous injection
1 mg/kg
Single administration, 8 hours post-injury
To evaluate the neuroprotective effect of Phenoxybenzamine after severe traumatic brain injury. Results showed that Phenoxybenzamine significantly improved neurological severity scores and foot fault assessments, and at 25 days post-injury, it significantly improved learning and memory compared to saline-treated controls. Additionally, Phenoxybenzamine-treated animals had significantly lower expression of pro-inflammatory signaling proteins CCL2, IL1β, and MyD88 at 32 hours post-TBI.
United States, California
... 展开 >>
University of California, Los angeles
Recruiting
Los Angeles, California, United States, 90025
Principal Investigator: Masha J Livhits, MD
Sub-Investigator: Eric J Kuo, MD 收起 <<
United States, California
... 展开 >>
University of California, Los angeles
Recruiting
Los Angeles, California, United States, 90025
Principal Investigator: Masha J Livhits, MD
Sub-Investigator: Eric J Kuo, MD 收起 <<
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