Carvedilol|BM 14190; SKF 105517; carvedilol hydrochloride; Coropres; Querto; Kredex; Eucardic; Carvedilolum; Dilatrend; Coreg; Carvedilol (free base)|Adrenergic Receptor|for research only|Ambeed

首页 / 抑制剂/激动剂 / / 肾上腺素能受体 / Carvedilol/卡维地洛

Carvedilol/卡维地洛 {[allProObj[0].p_purity_real_show]}

货号：A361863 同义名： BM 14190; SKF 105517

Carvedilol是一种非选择性β-肾上腺素受体拮抗剂（β₁ IC₅₀=0.6 nM；β₂ IC₅₀=4.5 nM）兼α₁受体拮抗剂（IC₅₀=2.1 nM），通过多通路协同发挥心脑保护作用。Carvedilol通过抑制 cAMP/PKA通路，减轻钙超载；激活 β-arrestin2/ERK1/2通路，促进心肌细胞存活；抑制 TGF-β1/Smad3通路，阻断纤维化；调节线粒体通透性转换孔（mPTP），减少氧化损伤。

Carvedilol/卡维地洛化学结构
CAS号：72956-09-3

Carvedilol/卡维地洛 3D分子结构
CAS号：72956-09-3

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Carvedilol/卡维地洛纯度/质量文件产品仅供科研

货号：A361863 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

肾上腺素能受体亚型比较

产品名称	Adrenergic Receptor ↓ ↑	α-adrenergic receptor ↓ ↑	β-adrenergic receptor ↓ ↑	纯度
Ivabradine HCl	✔			98%
Maprotiline HCl	✔			98%
Cisatracurium besylate	✔			96%
Yohimbine HCI		✔		99+%
BMY 7378		++ α1D-adrenoceptor, pKi: 5.1 α2C-adrenoceptor, pKi: 6.54	+ β1-adrenoceptor, pIC50: 5.1	97%
Asenapine maleate		++++ α2A-adrenergic receptor, pKi: 8.9 α2B-adrenergic receptor, pKi: 8.9		97%
Piribedil		++ adrenoceptor α2A, pKi: 7.1 adrenoceptor α2C, pKi: 7.2		98%
Prazosin HCl		✔		95%
Silodosin		✔		98%
Phenoxybenzamine HCl		✔		98%
Labetalol HCl		✔		98+%
Naftopidil		+++ α1D-adrenergic receptor, Ki: 20 nM α1A-adrenergic receptor, Ki: 3.7 nM		98%
Naftopidil 2HCl		+ α1-adrenergic receptor, IC50: 0.2 μM		99%
Alfuzosin HCl		✔		98%
Terazosin HCl		✔		99%
Atipamezole		✔		95%
Phentolamine methanesulfonate salt		✔		99%
Carvedilol		✔		99%
Doxazosin mesylate		✔		99%
Tolazoline HCl		✔		98%
Esmolol HCl			✔	95%
Propranolol HCl			++ β-adrenergic receptor, IC50: 12 nM	99%
Zenidolol HCl			++++ β2-adrenergic receptor, Ki: 0.7nM β1-adrenergic receptor, Ki: 611nM	98%
Acebutolol HCl			✔	97+%
Carteolol HCl			✔	98+%
Betaxolol			✔	99%
Betaxolol HCl			+ β1-adrenergic receptor, IC50: 6 μM	97%
Bisoprolol			✔	97%
Sotalol HCl			✔	95+%
Nebivolol HCl			+++ β1-adrenoceptor, IC50: 0.8 nM	99%
Metoprolol			✔	98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Carvedilol/卡维地洛生物活性

靶点	α-adrenergic receptor
描述	Carvedilol is a non-selective beta blocker/alpha-1 blocker with an IC50 of 3.8 μM for inhibition of LDL oxidation.

Carvedilol/卡维地洛细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
BESM cells		Cytotoxicity assay	88 h	Cytotoxicity against BESM cells after 88 hrs by HTS assay, EC50=31 μM	20547819
CHO cells		Function assay		Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique, IC50=10.4713 μM	18448342
HEK293 cells		Function assay	3 mins	Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay, IC50=7.5 μM	23241029
ScN2a-cl3 cells		Cytotoxicity assay		Cytotoxicity against mouse dividing ScN2a-cl3 cells assessed as cell viability after 5 days by calcein-AM staining-based fluorescence assay, LC50=6.1 μM	24183589

Carvedilol/卡维地洛临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00374465	Dilated Cardiomyopathy	Phase 4	Unknown	-	Poland ... 展开 >> Silesian Centre for Heart Disease, 3rd Department of Cardiology Recruiting Zabrze, Szpitalna 2 st., Poland, 41800 Principal Investigator: Romuald Wojnicz, MD, PhD Sub-Investigator: Ewa N Kozielska, MD, PhD Sub-Investigator: Jolanta Nowak, MD Sub-Investigator: Krzysztof Wilczek, MD Sub-Investigator: Celina Wojciechowska, MD Sub-Investigator: Bozena Szygula, MD 收起 <<
NCT01009918	Breast Cancer ... 展开 >> Cardiac Toxicity 收起 <<	Phase 2	Active, not recruiting	November 2018	-
NCT00384566	Heart Failure ... 展开 >> Chronic Obstructive Airway Disease 收起 <<	Phase 4	Withdrawn(In order to join for... 展开 >>ces with another study already running which aims to answer the same question.) 收起 <<	-	Australia, Victoria ... 展开 >> Alfred Hospital Melbourne, Victoria, Australia, 3004 收起 <<

Carvedilol/卡维地洛参考文献

[1]Chen J, Huang C, et al. The effects of carvedilol on cardiac structural remodeling: the role of endogenous nitric oxide in the activity of carvedilol. Mol Med Rep. 2013 Apr;7(4):1155-8.

[2]Stafylas PC, Sarafidis PA. Carvedilol in hypertension treatment. Vasc Health Risk Manag. 2008;4(1):23-30.

Carvedilol/卡维地洛实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.46mL

0.49mL

0.25mL

12.30mL

2.46mL

1.23mL

24.60mL

4.92mL

2.46mL

Carvedilol/卡维地洛技术信息

CAS号	72956-09-3
分子式	C₂₄H₂₆N₂O₄
分子量	406.47
SMILES Code	OC(CNCCOC1=CC=CC=C1OC)COC2=CC=CC(N3)=C2C4=C3C=CC=C4
MDL No.	MFCD00864692

别名	BM 14190; SKF 105517; carvedilol hydrochloride; Coropres; Querto; Kredex; Eucardic; Carvedilolum; Dilatrend; Coreg; Carvedilol (free base)
运输	蓝冰
InChI Key	OGHNVEJMJSYVRP-UHFFFAOYSA-N
Pubchem ID	2585

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, 2-8°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(258.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00374465	Dilated Cardiomyopathy	Phase 4	Unknown	-	Poland ... 展开 >> Silesian Centre for Heart Disease, 3rd Department of Cardiology Recruiting Zabrze, Szpitalna 2 st., Poland, 41800 Principal Investigator: Romuald Wojnicz, MD, PhD Sub-Investigator: Ewa N Kozielska, MD, PhD Sub-Investigator: Jolanta Nowak, MD Sub-Investigator: Krzysztof Wilczek, MD Sub-Investigator: Celina Wojciechowska, MD Sub-Investigator: Bozena Szygula, MD 收起 <<
NCT01009918	Breast Cancer ... 展开 >> Cardiac Toxicity 收起 <<	Phase 2	Active, not recruiting	November 2018	-
NCT00384566	Heart Failure ... 展开 >> Chronic Obstructive Airway Disease 收起 <<	Phase 4	Withdrawn(In order to join for... 展开 >>ces with another study already running which aims to answer the same question.) 收起 <<	-	Australia, Victoria ... 展开 >> Alfred Hospital Melbourne, Victoria, Australia, 3004 收起 <<
NCT02357004	Hypertensive	Not Applicable	Active, not recruiting	January 2019	United States, Alabama ... 展开 >> David A. Calhoun, MD Birmingham, Alabama, United States, 35294 收起 <<
NCT00553969	Pre-hypertension	Phase 1 Phase 2	Completed	-	United States, Minnesota ... 展开 >> University of Minnesota, Variety Club Research Center 102 Minneapolis, Minnesota, United States, 55455 收起 <<
NCT03370835	Pulmonary Disease, Chronic Obs... 展开 >>tructive Asthma Adverse Effect of Beta-adrenoreceptor Antagonists 收起 <<	Phase 4	Completed	-	United States, California ... 展开 >> VA West Los Angeles Medical Center Los Angeles, California, United States, 90073 收起 <<
NCT00493480	Cirrhosis Por... 展开 >>tal Hypertension 收起 <<	Phase 3	Completed	-	Denmark ... 展开 >> Hvidovre Hospital Hvidovre, Denmark, 2650 收起 <<
NCT03720067	Cirrhosis Por... 展开 >>tal Hypertension Variceal Hemorrhage 收起 <<	Phase 2 Phase 3	Recruiting	December 20, 2022	Brazil ... 展开 >> Universidade Federal do Rio de Janeiro Recruiting Rio de Janeiro, Brazil Contact: Guilherme FM Rezende, MD, PhD 55-21-999976292 guimottarezende@gmail.com Sub-Investigator: Andre Luiz M Torres, MD 收起 <<
NCT00000294	Cocaine-Related Disorders	Phase 2	Completed	-	United States, Minnesota ... 展开 >> University of Minnesota Minneapolis, Minnesota, United States, 55455 收起 <<
NCT00524134	Epilepsy	Phase 2 Phase 3	Terminated(PI left the institu... 展开 >>tion.) 收起 <<	-	United States, New York ... 展开 >> Columbia Comprehensive Epilepsy Center New York, New York, United States, 10032 收起 <<
NCT00060918	Hypertension	Phase 4	Completed	-	-
NCT00553969	-		Completed	-	-
NCT00129363	Congestive Heart Failure	Phase 3	Completed	-	United States, California ... 展开 >> Mattel Children's Hospital at UCLA Los Angeles, California, United States, 90025 Children's Hospital Los Angeles Los Angeles, California, United States, 90027 Stanford University Palo Alto, California, United States, 94303 United States, Colorado University of Colorado Denver, Colorado, United States, 80218 United States, Florida University of Miami Miami, Florida, United States, 33101 United States, Illinois Children's Memorial Hospital Chicago, Illinois, United States, 60614 United States, Massachusetts Children's Hospital, Boston Boston, Massachusetts, United States, 02115 United States, Michigan C.S. Mott Children's Hospital Ann Arbor, Michigan, United States, 48109 Children's Hospital of Michigan Detroit, Michigan, United States, 48201-2196 United States, Missouri Washington University St. Louis, Missouri, United States, 63110-1014 United States, New York Columbia University New York, New York, United States, 10032-1537 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee Vanderbilt Children's Hospital Nashville, Tennessee, United States, 37332 United States, Texas UT Southwestern Medical Center Dallas, Texas, United States, 75235-7794 Texas Children's Hospital Houston, Texas, United States, 77030 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 United States, Washington Seattle Childrens Hospital and Regional Medical Center Seattle, Washington, United States, 98105 收起 <<
NCT00060931	Hypertension	Phase 4	Completed	-	-
NCT00198614	Coronary Disease ... 展开 >> Atrial Fibrillation 收起 <<	Not Applicable	Completed	-	Japan ... 展开 >> National Cardiovascular Center Suita, Osaka, Japan, 565-8565 收起 <<
NCT01340248	Chronic Stable Angina	Phase 1	Completed	-	Korea, Republic of ... 展开 >> Kyungpook national university Daegu, Seoul, Korea, Republic of, 700-721 收起 <<
NCT00524134	-		Terminated(PI left the institu... 展开 >>tion.) 收起 <<	-	-
NCT01862497	-		Completed	-	United States, Texas ... 展开 >> University of Texas Southwestern Medical Center at Dallas Dallas, Texas, United States, 75390 收起 <<
NCT01196507	Cirrhosis	Not Applicable	Completed	-	India ... 展开 >> Institute of Liver & Biliary Sciences (ILBS) New Delhi, Delhi, India, 110 070 收起 <<
NCT01110824	Acute Myeloid Leukemia ... 展开 >> Precursor-cell Lymphoblastic Leukemia-Lymphoma Lymphoid Neoplasm Multiple Myeloma Lymphoma Autologous Hematopoietic Stem Cell Transplantation 收起 <<	Phase 3	Completed	-	Spain ... 展开 >> Hospital Clinic Barcelona, Catalunya, Spain, 08035 Hospital Clinic Barcelona, Catalunya, Spain, 08036 收起 <<
NCT00673075	Hypertension ... 展开 >>Coronary Artery Disease 收起 <<	Phase 4	Completed	-	-
NCT00108082	Hypertrophy, Left Ventricular	Phase 3	Completed	-	-
NCT00673075	-		Completed	-	-
NCT00108082	-		Completed	-	-
NCT00924833	Hypoxia Altit... 展开 >>ude Heart Failure 收起 <<	Phase 4	Completed	-	Italy ... 展开 >> Laboratorio Ricerche Cardiologiche. Istituto Auxologico Italiano. Ospedale S. Luca. Via Spagnoletto, 3. Regina Margherita Hut (Monte Rosa, Italian Alps, 4559 m) Milan, Italy, 20148 收起 <<
NCT00924833	-		Completed	-	-
NCT00240656	Hypertension, Pulmonary	Phase 1	Completed	-	China, Hebei ... 展开 >> The First Hospital of Hebei Medical University Shijiazhuang, Hebei, China, 050031 收起 <<
NCT01723371	Pulmonary Arterial Hypertensio... 展开 >>n 收起 <<	Phase 1 Phase 2	Withdrawn(Due to lack of enrol... 展开 >>lment.) 收起 <<	-	Canada, Ontario ... 展开 >> The Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 收起 <<
NCT00323037	Congestive Heart Failure	Phase 3	Completed	-	-
NCT00323037	-		Completed	-	-
NCT00273052	Hypertension	Phase 3	Completed	-	-
NCT02012075	Heart Failure	Phase 3	Unknown	-	China, Gansu ... 展开 >> Gansu Provincial Hospital Recruiting Lanzhou, Gansu, China China, Hubei Tongji Hospital Recruiting Wuhan, Hubei, China, 430030 China, Hunan The Second Xiangya Hospital of Central South University Recruiting Changsha, Hunan, China The Third Xiangya Hospital of Central South University Recruiting Changsha, Hunan, China China, Jiangsu Northern Jiangsu People's Hospital Recruiting Yangzhou, Jiangsu, China, 225001 China, Liaoning Shengjing Hospital of China Medical University Recruiting Shenyang, Liaoning, China, 110004 China, Zhejiang The First Affiliated Hospital of College of Medicine, Zhejiang University Recruiting Hangzhou, Zhejiang, China Taizhou Hospital Recruiting Taizhou, Zhejiang, China China Beijing ANZHEN Hospital Recruiting Beijing, China, 100029 Contact: Changsheng Ma, Professor 86-010-64456078 chshma@vip.sina.com Principal Investigator: Changsheng Ma, Professor China-Japan Friendship Hospital Recruiting Beijing, China, 100029 Xuan Wu Hospital affiliated to Capital Medical University Recruiting Beijing, China, 100053 Beijing Tongren hospital affiliated to Capital Medical University Recruiting Beijing, China 收起 <<
NCT00273052	-		Completed	-	-
NCT00650416	Healthy	Phase 1	Completed	-	United States, North Dakota ... 展开 >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 收起 <<
NCT00648622	Healthy	Phase 1	Completed	-	United States, North Dakota ... 展开 >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58104 收起 <<
NCT00732511	Endothelial Function ... 展开 >> Diabetes Mellitus Hypertension 收起 <<	Phase 4	Unknown	April 2009	United States, New York ... 展开 >> SUNY Downstate Medical Center Recruiting Brooklyn, New York, United States, 11203 Contact: Nathaniel Winer, M.D. 718-270-6320 nathaniel.winer@downstate.edu Contact: Rozina Rana, M.D. 516-279-8092 rrana786@gmail.com 收起 <<
NCT01970059	Hypertension	Phase 3	Unknown	-	China, Gansu ... 展开 >> Gansu Provincial Hospital Recruiting Lanzhou, Gansu, China China, Hebei The Fourth Hospital of Hebei Medical University Recruiting Shijiazhuang, Hebei, China China, Hunan The Second Xiangya Hospital of Central South University Recruiting Changsha, Hunan, China China, Jiangsu The Second Affiliated Hospital of Soochow University Recruiting Suzhou, Jiangsu, China Northern Jiangsu People's Hospital Recruiting Yangzhou, Jiangsu, China, 225001 China, Liaoning Shengjing Hospital of China Medical University Recruiting Shenyang, Liaoning, China, 110004 China, Shandong Qilu Hospital of Shandong University Recruiting Jinan, Shandong, China, 250012 Contact: Yun Zhang, Professor 86 135731022060 yun-zhang@163.com Principal Investigator: Yun Zhang, Professor China, Zhejiang Taizhou Hospital Recruiting Taizhou, Zhejiang, China China Xuan Wu hospital affiliated to Capital Medical University Recruiting Beijing, China, 100053 Beijing Tongren hospital affiliated to Capital Medical University Recruiting Beijing, China, 11691777 Longhua Hospital Shanghai University of Traditional Chinese Medicine Recruiting Shanghai, China 收起 <<
NCT01819870	Essential Hypertension ... 展开 >> Chronic Stable Angina Congestive Heart Failure 收起 <<	Phase 1	Unknown	August 2013	Korea, Republic of ... 展开 >> Kyungpook National University Hospital Clinical Trial Center Completed Daegu, eok-dong 2(i)-ga Jung-gu, Korea, Republic of, 700-721 收起 <<
NCT00347360	-		Completed	-	-
NCT03576664	Sleep Deprivation ... 展开 >> Sleep Wake Disorders Sleep 收起 <<	Early Phase 1	Recruiting	April 1, 2019	Denmark ... 展开 >> Neurobiology Research Unit, Rigshospitalet Recruiting Copenhagen, Denmark, 2100 Contact: Sebastian C Holst, PhD +45 71421746 holst@nru.dk Contact: Peter S Jensen, MSc peje@nru.dk 收起 <<
NCT00347360	Hypertension	Phase 3	Completed	-	-
NCT00624065	Hypertension	Phase 3	Completed	-	-
NCT03542058	Chemotherapy Related Cardiac D... 展开 >>ysfunction 收起 <<	Phase 3	Not yet recruiting	June 2021	-
NCT02251509	Atrial Fibrillation	Phase 4	Unknown	September 2017	United States, Nebraska ... 展开 >> Creighton University Recruiting Omaha, Nebraska, United States, 68178 Contact: Caroline Nubel 402-280-4032 carolinenubel@creighton.edu Principal Investigator: Pallavi Bellamkonda, MBBS 收起 <<
NCT00537043	Hypertension	Phase 1	Completed	-	United States, New Jersey ... 展开 >> GSK Investigational Site Hackensack, New Jersey, United States, 07601 United States, Texas GSK Investigational Site Austin, Texas, United States, 78704 收起 <<
NCT03069339	Cirrhosis	Not Applicable	Recruiting	March 15, 2019	India ... 展开 >> Institute of liver and Biliary Sciences Recruiting New Delhi, Delhi, India, 110070 Contact: Dr Apurva Pandey, MD +91-11-01146300000 pandeap@gmail.com 收起 <<
NCT00444834	Hypertension	Phase 2	Terminated(IMP supply)	-	Denmark ... 展开 >> Site 02 Esbjerg, Denmark Site 01 Frederiksberg, Denmark 收起 <<
NCT00052026	Congestive Heart Failure	Phase 3	Completed	-	United States, Alabama ... 展开 >> University of Alabama Birmingham, Alabama, United States, 35249-6852 United States, California Mattel Children's Hospital at UCLA Los Angeles, California, United States, 90025 Children's Hospital Los Angeles Los Angeles, California, United States, 90027 Stanford University Palo Alto, California, United States, 94303 United States, Colorado University of Colorado Denver, Colorado, United States, 80218 United States, Florida University of Miami Miami, Florida, United States, 33101 University of Southern Florida St. Petersburg, Florida, United States, 33701 United States, Illinois Children's Memorial Hospital Chicago, Illinois, United States, 60614 United States, Massachusetts Children's Hospital, Boston Boston, Massachusetts, United States, 02115 United States, Michigan C.S. Mott Children's Hospital Ann Arbor, Michigan, United States, 48109 Children's Hospital of Michigan Detroit, Michigan, United States, 48201-2196 United States, Missouri Washington University St. Louis, Missouri, United States, 63110-1014 United States, New York NYU Medical Center New York, New York, United States, 10016 Columbia University New York, New York, United States, 10032-1537 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Tennessee Vanderbilt Children's Hospital Nashville, Tennessee, United States, 37332 United States, Texas UT Southwestern Medical Center Dallas, Texas, United States, 75235-7794 Texas Children's Hospital Houston, Texas, United States, 77030 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 United States, Washington Seattle Childrens Hospital and Regional Medical Center Seattle, Washington, United States, 98105 收起 <<
NCT00669279	Hypertension	Phase 4	Completed	-	United States, Florida ... 展开 >> University of Florida Gainesville, Florida, United States, 32610 收起 <<
NCT00819845	Duchenne Muscular Dystrophy ... 展开 >> Becker Muscular Dystrophy 收起 <<	Phase 4	Unknown	December 2016	Italy ... 展开 >> Unione Italiana lotta Distrofia Muscolare Recruiting Rome, Italy, 00167 Contact: Vincenzo Giglio, MD, PhD 39-6-6604881 giglio.echo@libero.it Contact: Fortunato Mangiola, MD 39-6-6604881 fortunato.mangiola@uildmlazio.org Principal Investigator: Vincenzo Giglio, MD, PhD 收起 <<
NCT00606775	Duchenne Muscular Dystrophy ... 展开 >> Cardiomyopathies 收起 <<	Phase 4	Unknown	December 2012	Japan ... 展开 >> Suzuka Hospial Recruiting Suzuka, Mie, Japan, 513-8501 Contact: Takao Nishizawa, MD. PhD +81-52-744-2150 nishizta@med.nagoya-u.ac.jp Contact: Fumihiko Yasuma, MD. PhD +81-593-78-0337 yasuma@suzuka.go.jp Sub-Investigator: Fumihiko Yasuma, MD, PhD Sub-Investigator: Toshimitsu Mori, MD Sub-Investigator: Motoko Sakai, MD, PhD Sub-Investigator: Satoshi Kuru, MD, PhD Sub-Investigator: Seigo Kimura, MD Sub-Investigator: Takuya Tamura, MD Sub-Investigator: Kentaro Sahashi, MD Sub-Investigator: Rei Shibata, MD, PhD Sub-Investigator: Taiki Ohashi, MD 收起 <<
NCT01155635	Myocardial Infarction	Phase 4	Completed	-	Japan ... 展开 >> Division of Cardiology, Kyoto University Hospital Kyoto, Japan, 606-8507 收起 <<
NCT02717507	Cancer Survivor	Phase 2	Recruiting	-	-
NCT02465645	Cirrhosis With Esophageal Vari... 展开 >>ces 收起 <<	Not Applicable	Completed	-	India ... 展开 >> Institute of Liver and Biliary Sciences New Delhi, Delhi, India, 110070 收起 <<
NCT00669279	-		Completed	-	-
NCT00552708	Hypertension	Phase 1	Completed	-	United States, Washington ... 展开 >> GSK Investigational Site Tacoma, Washington, United States, 98418 收起 <<
NCT00585091	Heart Failure	Not Applicable	Completed	-	United States, Utah ... 展开 >> University of Utah Salt Lake City, Utah, United States, 84112 收起 <<
NCT01793870	Metabolic, Cardiovascular	Phase 1	Completed	-	United Kingdom ... 展开 >> GSK Investigational Site Cambridge, United Kingdom, CB2 2GG 收起 <<
NCT01568645	Pulmonary Hypertension	Phase 1	Withdrawn	-	-
NCT00123604	Hypertension ... 展开 >>Type 2 Diabetes Mellitus 收起 <<	Phase 4	Completed	-	United States, Minnesota ... 展开 >> St. Paul Heart Clinic St. Paul, Minnesota, United States, 55102 收起 <<
NCT01425164	Coronary Heart Disease ... 展开 >> Angina Hemodialysis 收起 <<	Phase 4	Unknown	June 2012	Italy ... 展开 >> Chair of Cardiology Second University of Naples Recruiting Naples, Italy, 80100 收起 <<
NCT01212250	Cirrhosis	Not Applicable	Recruiting	December 1, 2018	India ... 展开 >> Institute of Liver & Biliary Sciences (ILBS) Recruiting New Delhi, Delhi, India Contact: Ankur Jindal, DM 9582670984 ankur.jindal3@gmail.com Principal Investigator: Ankur Jindal, MBBS, MD, DM 收起 <<
NCT01196481	Cirrhosis	Not Applicable	Completed	-	India ... 展开 >> Institute of Liver & Biliary Sciences (ILBS) New Delhi, Delhi, India, 110 070 收起 <<
NCT00459056	Abdominal Obesity ... 展开 >> Hypertension 收起 <<	Phase 3	Completed	-	United States, Minnesota ... 展开 >> St. Paul Heart Clinic St. Paul, Minnesota, United States, 55102 收起 <<
NCT00624065	-		Completed	-	-
NCT00638222	Vascular Disease ... 展开 >> Kidney Disease 收起 <<	Not Applicable	Terminated(Poor enrollment)	-	United States, Ohio ... 展开 >> University of Toledo, Health Science Campus Toledo, Ohio, United States, 43606 United States, Rhode Island Site Rhode Island Hospital Providence, Rhode Island, United States, 02903 收起 <<
NCT00657241	Hypertension	Phase 3	Completed	-	United States, New York ... 展开 >> Erie County Medical Center Buffalo, New York, United States, 14215 收起 <<
NCT00123604	-		Completed	-	-
NCT03775096	REM Sleep Behavior Disorder ... 展开 >> Pre-motor Parkinson Disease Symptomatic Parkinson Disease 收起 <<	Phase 2	Not yet recruiting	December 2019	-
NCT00459056	-		Completed	-	-
NCT02619526	Heart Failure	Not Applicable	Recruiting	December 2018	Korea, Republic of ... 展开 >> Department of Internal Medicine,Dong-A University College of Medicine Recruiting Busan, Korea, Republic of Contact: Kyungil Park, MD 82-51-240-2733 sotier@dau.ac.kr 收起 <<
NCT00775619	Healthy	Not Applicable	Completed	-	-
NCT00638222	-		Terminated(Poor enrollment)	-	-
NCT00834795	Healthy	Phase 1	Completed	-	United States, Missouri ... 展开 >> Gateway Medical Research, Inc. St. Charles, Missouri, United States, 63301 收起 <<
NCT00834873	Healthy	Phase 1	Completed	-	United States, Missouri ... 展开 >> Gateway Medical Research, Inc. St. Charles, Missouri, United States, 63301 收起 <<
NCT00834795	-		Completed	-	-
NCT00566969	-		Completed	-	-
NCT00834873	-		Completed	-	-
NCT01070641	Portal Hypertension	Phase 4	Unknown	July 2011	Pakistan ... 展开 >> Aga Khan University Hospital Recruiting Karachi, Sindh, Pakistan, 74800 Contact: Syed Hasnain A Shah, MBBS, FRCP 00922134930051 ext 4676 hasnail.alishah@aku.edu Principal Investigator: Syed Hasnain A Shah, FRCP Sub-Investigator: Amna Butt, MBBS, FCPS Sub-Investigator: Ambreen Pyarali, MBBS 收起 <<
NCT02944201	Prostate Cancer	Phase 2	Recruiting	December 2018	United States, New York ... 展开 >> Montefiore Medical Center Recruiting Bronx, New York, United States, 10461 Contact: Benjamin Gartrell, MD 718-405-8404 bgartrel@montefiore.org 收起 <<
NCT00776113	Healthy	Not Applicable	Completed	-	-
NCT00566969	Cocaine Dependence ... 展开 >> Opiate Dependence 收起 <<	Not Applicable	Completed	-	United States, Connecticut ... 展开 >> Veterans Hospital West Haven, Connecticut, United States, 06516 收起 <<
NCT01586156	Pulmonary Hypertension	Not Applicable	Completed	-	United States, Ohio ... 展开 >> Cleveland Clinic Cleveland, Ohio, United States, 44195 收起 <<
NCT01221792	Post-Traumatic Stress Disorder	Phase 2	Unknown	August 2011	United States, California ... 展开 >> Artemis Institute for Clinical Research San Diego, California, United States, 92123 United States, Louisiana Lake Charles Clinical Trials Lake Charles, Louisiana, United States, 70601 United States, Washington Northwest Clinical Research Center Bellevue, Washington, United States, 98007 收起 <<
NCT02177175	Breast Cancer	Phase 2	Active, not recruiting	June 2019	United States, New York ... 展开 >> Memorial Sloan Kettering West Harrison Harrison, New York, United States, 10604 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 收起 <<
NCT01586156	-		Completed	-	-
NCT00864149	Healthy	Phase 1	Completed	-	Canada, Ontario ... 展开 >> Biovail Contract Research (A Division of Biovail Corporation) Toronto, Ontario, Canada, M1L 4S4 / M1L 4R6 收起 <<
NCT03418961	Cardiotoxicity ... 展开 >> HER2/Neu Positive Metastatic Malignant Neoplasm in the Brain Recurrent Breast Carcinoma Stage IV Breast Cancer AJCC v6 and v7 收起 <<	Phase 3	Recruiting	February 1, 2023	-
NCT02120339	Pulmonary Hypertension ... 展开 >> Cardiac MRI <40 收起 <<	Phase 2	Terminated(Low enrollment)	-	United States, Minnesota ... 展开 >> University of Minnesota Minneapolis, Minnesota, United States, 55414 收起 <<
NCT01724450	Breast Cancer ... 展开 >> Heart Failure Cardiotoxicity 收起 <<	Phase 3	Completed	-	Brazil ... 展开 >> Heart Institute University of Sao Paulo Sao Paulo, Brazil, 05403-000 收起 <<
NCT01243827	Hypertension	Phase 4	Unknown	April 2013	Japan ... 展开 >> Iwakuni City Medical Center Recruiting Yamaguchi, Japan Contact: Yoshio Matsui +81-827-21-3211 yoshio@jichi.ac.jp 收起 <<
NCT02547597	Stable Angina Pectoris	Phase 4	Completed	-	Korea, Republic of ... 展开 >> Gachon University Gil Medical Center Incheon, Korea, Republic of, 405-760 收起 <<
NCT01577914	Fasting State	Phase 1	Completed	-	India ... 展开 >> Accutest Research Lab (I) Pvt. Ltd. Ahmedabad, Gujarat, India 收起 <<
NCT01270672	Mood Disorder ... 展开 >> Substance-Related Disorders Amphetamine-Related Disorders 收起 <<	Not Applicable	Completed	-	Switzerland ... 展开 >> Clinical Pharmacology & Toxicology, University Hospital Basel Basel, Switzerland, 4053 收起 <<
NCT01484327	-		Completed	-	Greece ... 展开 >> Cardiology University Clinic Alexandroupolis, Greece 收起 <<
NCT00964678	-		Completed	-	-
NCT02385422	Liver Cirrhosis ... 展开 >> Esophageal and Gastric Varices Hemorrhage 收起 <<	Phase 4	Unknown	November 2017	China, Shanghai ... 展开 >> Shanghai Zhongshan Hospital Recruiting Shanghai, Shanghai, China, 200032 Contact: Yichao Wei, Doctor 86-13918891342 08301010253@fudan.edu.cn Principal Investigator: Shiyao Chen, Professor 收起 <<
NCT00964678	Pulmonary Arterial Hypertensio... 展开 >>n 收起 <<	Phase 1 Phase 2	Completed	-	United States, Virginia ... 展开 >> Virginia Commonwealth University Richmond, Virginia, United States, 23298 收起 <<
NCT01557140	Chagas Cardiomyopathy ... 展开 >> Heart Failure Dilated Cardiomyopathy 收起 <<	Phase 4	Completed	-	Brazil ... 展开 >> Chagas Disease Outpatient Center of the Federal University of Minas Gerais Belo Horizonte, Minas Gerais, Brazil 收起 <<
NCT01171183	Cocaine Dependence ... 展开 >> Cocaine Withdrawal 收起 <<	Phase 2	Completed	-	United States, Arkansas ... 展开 >> University of Arkansas for Medical Sciences Little Rock, Arkansas, United States, 72205 收起 <<
NCT01171183	-		Completed	-	-
NCT01608893	Atrial Fibrillation	Not Applicable	Recruiting	June 2020	Canada, Alberta ... 展开 >> University of Calgary Recruiting Calgary, Alberta, Canada, T2N 4Z6 Contact: Anne Gillis Contact: Jennifer McKeage Principal Investigator: Anne M Gillis, M.D. Sub-Investigator: Henry Duff, M.D. Sub-Investigator: Derek Exner, M.D. Sub-Investigator: Katherine Kavanagh, M.D. Sub-Investigator: Vikas Kuriachan, M.D. Sub-Investigator: Brent Mitchell, M.D. Sub-Investigator: Timothy Pollack, M.D. Sub-Investigator: Russell Quinn, M.D. Sub-Investigator: Robert Sheldon, M.D. Sub-Investigator: Glen Sumner, M.D. Sub-Investigator: George Veenhuyzen, M.D. Sub-Investigator: Stephen Wilton, M.D. Sub-Investigator: George Wyse, M.D. 收起 <<
NCT02504723	Esophageal and Gastric Varices	Phase 4	Completed	-	Taiwan ... 展开 >> Kaohsiung Veterans General Hospital Kaohsiung, Taiwan, 813 收起 <<
NCT02695732	Liver Cirrhosis ... 展开 >> Esophageal and Gastric Varices 收起 <<	Phase 4	Unknown	September 2018	China ... 展开 >> Zhongshan Hospital Recruiting Shanghai, China Contact: Chu Liu, doctor 86-15201928343 09301010159@fudan.edu.cn Principal Investigator: Shiyao Chen, professor 收起 <<
NCT00864435	Healthy	Phase 1	Completed	-	Canada, Ontario ... 展开 >> Biovail Contract Research (A Division of Biovail Corporation) Toronto, Ontario, Canada, M1L 4S4 / M1L 4R6 收起 <<
NCT01103154	Variceal Rebleeding	Phase 4	Completed	-	-
NCT01354444	Alzheimer's Disease	Phase 4	Completed	-	United States, Maryland ... 展开 >> Johns Hopkins School of Medicine Bayview Campus Baltimore, Maryland, United States, 21224 收起 <<
NCT01354444	-		Completed	-	-
NCT02504723	-		Completed	-	-
NCT01383044	Variceal Bleeding	Phase 4	Unknown	June 2014	Taiwan ... 展开 >> E-DA hospital Recruiting Kaogsiung, Taiwan, 82445 Contact: Gin Ho Lo, MD 0975106248 收起 <<
NCT02066649	Portal Hypertension Related to... 展开 >> Cirrhosis 收起 <<	Phase 3	Withdrawn(We need to revise an... 展开 >>d redesign the study) 收起 <<	September 2021	United States, New Jersey ... 展开 >> Rutgers NJ Medical School Newark, New Jersey, United States, 07103 收起 <<
NCT01064180	Healthy	Phase 1	Completed	-	-
NCT01756430	Hypertension	Phase 3	Completed	-	Korea, Republic of ... 展开 >> The Hanyang Universitiy Guri Hospital Guri-si, Gyeonggi-do, Korea, Republic of, 471-701 收起 <<
NCT02286934	Healthy	Phase 1	Completed	-	Korea, Republic of ... 展开 >> Seoul National University Bundang Hospital Seongnam, Gyounggi, Korea, Republic of 收起 <<
NCT02946892	Single Ventricle ... 展开 >> Fontan 收起 <<	Phase 4	Recruiting	January 2019	United States, Texas ... 展开 >> University of Texas Southwestern Recruiting Dallas, Texas, United States, 75390 Contact: Ryan M Butts, MD ryan.butts@utsouthwestern.edu Principal Investigator: Ryan J Butts, MD 收起 <<
NCT01064154	Healthy	Phase 1	Completed	-	-
NCT02832089	Atrial Fibrillation	Phase 3	Completed	-	-
NCT03587558	Ventricular Premature Complexe... 展开 >>s Outflow Tract Carvedilol 收起 <<	Phase 4	Recruiting	December 31, 2020	Korea, Republic of ... 展开 >> Keimyung University Dongsan Medical Center Recruiting Daegu, Korea, Republic of, 41931 Contact: Jongmin Hwang, M.D. +82-53-250-7333 dsmcep@dsmc.or.kr Principal Investigator: Seongwook Han, MD, PhD Sub-Investigator: Yoon-Nyun Kim, MD, PhD Sub-Investigator: Hyoung-Seob Park, MD, PhD Sub-Investigator: Jongmin Hwang, MD, PhD Division of Cardiology, Department of Internal Medicine, Kyungpook National University Hospital Recruiting Daegu, Korea, Republic of, 41944 Contact: Myung Hwan Bae, MD, PhD Division of Cardiology, Department of Internal Medicine, Yeungnam University Hospital Recruiting Daegu, Korea, Republic of, 42415 Contact: Dong Gu Shin, MD, PhD Division of Cardiology, Department of Internal Medicine, Daegu Catholic University Medical Center Recruiting Daegu, Korea, Republic of, 42472 Contact: Young Soo Lee, MD, PhD Chonnam National University Hospital Recruiting Gwangju, Korea, Republic of, 61469 Contact: Hyung Wook Park, MD, PhD Korea University Anam Hospital Recruiting Seoul, Korea, Republic of, 02841 Contact: Jong-Il Choi, MD, PhD Seoul National University Hospital Recruiting Seoul, Korea, Republic of, 03080 Contact: Eue-Keun Choi, MD, PhD Severance Cardiovascular Hospital Recruiting Seoul, Korea, Republic of, 03722 Contact: Boyoung Joung, MD, PhD Seoul Asan Medical Center Recruiting Seoul, Korea, Republic of, 05505 Contact: Jun Kim, MD, PhD Seoul Samsung Medical Center Recruiting Seoul, Korea, Republic of, 06351 Contact: Young Keun On, MD, PhD Seoul St. Mary's Hospital Recruiting Seoul, Korea, Republic of, 06591 Contact: Sung-Hwan Kim 收起 <<
NCT03538015	Hypoglycemia Unawareness	Phase 2	Not yet recruiting	June 2020	United States, Utah ... 展开 >> University of Utah Not yet recruiting Salt Lake City, Utah, United States, 84132 收起 <<
NCT03736265	Cirrhosis, Liver ... 展开 >> Portal Hypertension 收起 <<	Not Applicable	Recruiting	December 2021	China, Beijing ... 展开 >> Beijing Ditan Hospital Capital Medical University Recruiting Beijing, Beijing, China, 100015 Contact: Wen Xie Xiewen6218@163.com Peking University First Hospital Recruiting Beijing, Beijing, China, 100034 Contact: Xiaoyuan Xu yangpin@public3.bta.net.com Peking University People's Hospital Recruiting Beijing, Beijing, China, 100044 Contact: Bo Feng xyfyfb_1@sina.com Beijing Friendship Hospital Recruiting Beijing, Beijing, China, 100050 Contact: Xiaoning Wu China, Shanghai Zhongshan Hospital Fudan University Recruiting Shanghai, Shanghai, China, 200032 Contact: Wei Jiang jiang.wei@zs-hospital.sh.cn The First Affiliated Hospital of Shanghai Jiao Tong University Recruiting Shanghai, Shanghai, China, 201620 Contact: Mingyi Xu xumingyi@hotmail.com 收起 <<
NCT03209180	Heart Failure With Reduced Eje... 展开 >>ction Fraction 收起 <<	Phase 4	Recruiting	December 31, 2018	Korea, Republic of ... 展开 >> Sejong Hospital Recruiting Gyeonggi-do, Bucheon, Korea, Republic of, 14754 Contact: Suk-keun Hong, MD 82-10-8947-5309 hongsk11@hanmail.net Gangdong Sacred Heart Hospital Recruiting Seoul, Gangdong, Korea, Republic of, 05355 Contact: Dae-gyun Park, MD 82-2-2224-2379 dgpark@hallym.or.kr Korea Univ. Guro Hospital Recruiting Seoul, Guro, Korea, Republic of, 08308 Contact: Eung-joo Kim, MD,PhD 82-8-2626-3022 withnoel@empas.com Samsung Medical Center Recruiting Seoul, Il-won, Korea, Republic of, 06351 Contact: Eun-Seok Jeon, MD,PhD 82-2-3410-3448 esjeon1107@gmail.com Seoul Medical Center Recruiting Seoul, Jungnang, Korea, Republic of, 02053 Contact: Seok-Yeon Kim, MD 82-2-2276-7095 ks7688@hanmail.net Korea Univ. Anam Hospital Recruiting Seoul, Seongbuk, Korea, Republic of, 02841 Contact: Sun-jun Hong, MD,PhD 82-2-920-5445 psyche94@hanmail.net Asan Medical Center Recruiting Seoul, Songpa, Korea, Republic of, 05505 Contact: Jae-Joong Kim, MD,PhD 82-2-3010-3154 jjkim@amc.seoul.kr Ajou Univ. Medical Center Recruiting Suwon-si, Yeong-tong, Korea, Republic of, 16499 Contact: Jun-han Shin, MD,PhD 82-31-219-5710 shinjh@ajou.ac.kr Seoul National University Bundang Hospital Recruiting Seongnam, Korea, Republic of, 463707 Contact: Dong-Ju Choi, MD, PhD 82-31-787-7007 djchoi@snubh.org Contact: Jin Joo Park, MD 82-31-787 ext 7074 jinjooparkmd@gmail.com Severance Hospital Recruiting Seoul, Korea, Republic of, 03722 Contact: Seok-Min Kang, MD,PhD 82-2-2273-3339 smkang@yuhs.ac Seoul Metropolitan Government Seoul National University Boramae Medical Center Recruiting Seoul, Korea, Republic of, 07061 Contact: Myung-a Kim 82-2-870-2213 kma@brmh.org Seoul National University Hospital Recruiting Seoul, Korea, Republic of, 110744 Contact: Hae-Young Lee, MD,Ph D 82-2-2072-4875 hylee612@gmail.com Wonju Severance Christian Hospital Recruiting Wonju, Korea, Republic of, 26426 Contact: Byung-Su Yoo, MD,PhD 82-33-741-0908 yubs@yonsei.ac.kr 收起 <<

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