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首页 / 抑制剂/激动剂 / 神经信号通路 / AChR / Cisatracurium besylate/苯磺顺阿曲库铵

Cisatracurium besylate/苯磺顺阿曲库铵 {[allProObj[0].p_purity_real_show]}

货号：A153975 同义名： 顺苯磺酸阿曲库铵 / 51W89 besylate; Cisatracurium besilate

Cisatracurium besylate 是一种非去极化神经肌肉阻断剂，能通过抑制神经肌肉的传递拮抗乙酰胆碱的效用。

Cisatracurium besylate/苯磺顺阿曲库铵 化学结构 CAS号：96946-42-8
Cisatracurium besylate/苯磺顺阿曲库铵 化学结构
CAS号：96946-42-8
Cisatracurium besylate/苯磺顺阿曲库铵 3D分子结构
CAS号：96946-42-8
Cisatracurium besylate/苯磺顺阿曲库铵 化学结构 CAS号：96946-42-8
Cisatracurium besylate/苯磺顺阿曲库铵 3D分子结构 CAS号：96946-42-8
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Cisatracurium besylate/苯磺顺阿曲库铵 纯度/质量文件 产品仅供科研

货号：A153975 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		95%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 97%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 99%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine HCl ✔ 99%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 97%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		99%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M2 mAChR, Ki: 0.1 nM

M4 mAChR, Ki: 0.21 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Cisatracurium besylate/苯磺顺阿曲库铵 生物活性

靶点

  • Adrenergic Receptor
描述 Cisatracurium Besylate is an ideal non-depolarizing muscle relaxant. The inhibitory effect of cisatracurium besylate on the proliferation activity of endothelial cells was time-dependent. Cisatracurium Besylate (0, 5, 25, or 100 µM) make the number of the autolysomes increases in a concentration dependent manner. Moreover, cisatracurium besylate can injure cells through autophagic cell death[3]. Cisatracurium besylate is frequently used in the intensive care unit in order to induce muscle relaxation to facilitate mechanical ventilation in critically ill patients[4].

Cisatracurium besylate/苯磺顺阿曲库铵 细胞实验

Cell Line
Concentration Treated Time Description References
mouse MLTC-1 tumor cells 5, 10, 50 μmol/L 12 h Cisatracurium significantly increased testosterone output in mouse MLTC-1 cells J Cell Mol Med. 2020 Dec;24(24):14184-14194
rat adult Leydig cells 5, 10, 50 μmol/L 12 h Cisatracurium significantly increased testosterone output in rat Leydig cells J Cell Mol Med. 2020 Dec;24(24):14184-14194
Human microvascular endothelial cells (HMECs) 0.32, 0.64, and 1.28 μM 24 h To investigate the effect of cisatracurium on LPS-induced MMP3 expression. Results showed that cisatracurium significantly decreased LPS-induced MMP3 expression and increased the expression of junctional proteins such as VE-cadherin and claudin-5. Biosci Trends. 2021 Mar 15;15(1):50-54

Cisatracurium besylate/苯磺顺阿曲库铵 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01181349 - Completed - -
NCT02793323 Relieve Shoulder Pain After La... 展开 >>paroscopic Surgeries 收起 << Not Applicable Completed - Lebanon ... 展开 >> Makassed General Hospital Beirut, Lebanon 收起 <<
NCT02154074 Perioperative Blood Glucose an... 展开 >>d Insulin 收起 << Phase 4 Unknown October 2014 China, Shanxi ... 展开 >> SecondXianJiaotongU Recruiting Xi'an, Shanxi, China Contact: Hongtao Liu    13572225310    lannylouis@163.com 收起 <<

Cisatracurium besylate/苯磺顺阿曲库铵 参考文献

[1]Zhang H, Wang P, et al. HPLC determination of cisatracurium besylate and propofol mixtures with LC-MS identification of degradation products. J Pharm Biomed Anal. 1998 Mar;16(7):1241-9.

[2]Dear GJ, Harrelson JC, et al. Identification of urinary and biliary conjugated metabolites of the neuromuscular blocker 51W89 by liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 1995;9(14):1457-64.

[3]Zhuang H, Tian W, Li W, Zhang X, Wang J, Yang Y, Liu X, Xia Z, Feng D, Zhang L. Autophagic Cell Death and Apoptosis Jointly Mediate Cisatracurium Besylate-Induced Cell Injury. Int J Mol Sci. 2016 Apr 6;17(4):515.

[4]Meeder AM, van der Steen MS, Rozendaal A, van Zanten AR. Phlebitis as a consequence of peripheral intravenous administration of cisatracurium besylate in critically ill patients. BMJ Case Rep. 2016 Oct 3;2016:bcr2016216448.

Cisatracurium besylate/苯磺顺阿曲库铵 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.80mL

0.16mL

0.08mL

4.02mL

0.80mL

0.40mL

8.04mL

1.61mL

0.80mL

Cisatracurium besylate/苯磺顺阿曲库铵 技术信息

CAS号96946-42-8
分子式C65H82N2O18S2
分子量 1243.48
SMILES Code O=C(OCCCCCOC(CC[N@+]1(C)[C@H](CC2=CC=C(OC)C(OC)=C2)C3=C(C=C(OC)C(OC)=C3)CC1)=O)CC[N@+]4(C)[C@H](CC5=CC=C(OC)C(OC)=C5)C6=C(C=C(OC)C(OC)=C6)CC4.O=S(C7=CC=CC=C7)([O-])=O.O=S(C8=CC=CC=C8)([O-])=O
MDL No. MFCD00871018
别名 顺苯磺酸阿曲库铵 ;51W89 besylate; Cisatracurium besilate; Cisatracurium (besylate); 51W89
运输蓝冰
InChI Key XXZSQOVSEBAPGS-DONVQRBFSA-L
Pubchem ID 62886
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, store in freezer, under -20°C
溶解方案

H2O: 50 mg/mL(40.21 mM)

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Cisatracurium besylate | 96946-42-8 | 51W89 besylate | Cisatracurium | Autophagy Inducer | Membrane Transporter/Ion Channel | Neuronal Signaling | Autophagy | nAChR | Autophagy | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Cisatracurium besylate/苯磺顺阿曲库铵 纯度/质量文件 | Cisatracurium besylate/苯磺顺阿曲库铵 亚型比较 | Cisatracurium besylate/苯磺顺阿曲库铵 生物活性 | Cisatracurium besylate/苯磺顺阿曲库铵 临床数据 | Cisatracurium besylate/苯磺顺阿曲库铵 参考文献 | Cisatracurium besylate/苯磺顺阿曲库铵 实验方案 | Cisatracurium besylate/苯磺顺阿曲库铵 技术信息

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