There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Phenylbutazone (PB), a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Prostacyclin synthase is even more sensitive to inactivation by the combined PB and H2O2 treatment, with a corresponding half-maximal effect at PB concentrations near 25 mM[3]. However at IC80, phenylbutazone (+134.4%) and flunixin (+29.7%) had greater COX-2 selectivity than at IC50[4]. Phenylbutazone acts by inhibiting the cyclooxygenase enzyme system, which is responsible for synthesis of prostanoids such as PGE2. It markedly reduces prostanoid-dependent swelling, edema, erythema, and hypersensitivity to pain in inflamed tissues. Phenylbutazone is highly bound (greater than 98%) to plasma protein. After i.v. injection, blood levels decline with an elimination half-life of 3-10 h. The plasma kinetics of phenylbutazone may be dose dependent, with the plasma half-life increasing as the drug dosage level increases. Plasma residues of the drug at 24 h after a single i.v. dose of 2g/450 kg average about 0.9 mg/ml, but considerable variation occurs. Under optimal conditions, the bioavailability of oral phenylbutazone is probably in the region of 70%[5].
Phenylbutazone/保泰松 细胞实验
Cell Line
Concentration
Treated Time
Description
References
YAMC cells
0.4 mM
24 h
To investigate the effect of Phenylbutazone on p62 nuclear translocation in YAMC cells, results showed that Phenylbutazone increased nuclear translocation of p62, indicating potential induction of endoplasmic reticulum stress.
Microbiome. 2024 Apr 15;12(1):74.
Phenylbutazone/保泰松 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Horses
NSAID-induced intestinal inflammation model
Oral
4.4 mg/kg
Once daily for 9 days
To study the effects of Phenylbutazone on a horse model of intestinal inflammation, results showed that Phenylbutazone induced changes in the microbiota, metabolome, and host transcriptome, correlating with genes and metabolites linked to oxidative stress.
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