Ipratropium bromide

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Chemical Structure| 22254-24-6 同义名 : Sch 1000; Ipratropium (bromide)
CAS号 : 22254-24-6
货号 : A163960
分子式 : C20H30BrNO3
纯度 : 98%
分子量 : 412.36
MDL号 : MFCD00069291
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(84.88 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(242.51 mM)，配合低频超声助溶
生物活性
靶点

  • mAChR
描述 Ipratropium Bromide, as short‐acting anticholinergic, is indicated for the maintenance treatment of bronchospasm associated with COPD (chronic obstructive pulmonary disease), including chronic bronchitis and emphysema[3]. Both IB (Ipratropium Bromide) and AS (Albuterol Sulfate) elicit significant bronchodilation, although the magnitude of the bronchodilator response is greater following IB[4]. Moreover, routine nebulized ipratropium bromide premedication for bronchoscopy could be useful and beneficial[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03405090 Chronic Obstructive Pulmonary ... 展开 >>Disease 收起 << Phase 4 Recruiting August 2019 Canada, Ontario ... 展开 >> Respiratory Investigation Unit Recruiting Kingston, Ontario, Canada, K7L 2V7 Contact: Megha Ibrahim Masthan, MSc    613-549-6666 ext 4314    mim5@queensu.ca    Contact: Sandra Vincent    613-549-6666 ext 4890    vincents@queensu.ca    Principal Investigator: Denis E O'Donnell, MD, FRCPC 收起 <<
NCT00498251 Lung Injury, Acute ... 展开 >> Thoracotomy Anesthesia Intensive Care, Surgical Extravascular Lung Water 收起 << Not Applicable Completed - Switzerland ... 展开 >> University Hospital of Geneva Geneva, Switzerland, CH-1211 收起 <<
NCT01395875 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.43mL

0.49mL

0.24mL

12.13mL

2.43mL

1.21mL

24.25mL

4.85mL

2.43mL
参考文献

[1]Zhang W, et al. Eur J Pharmacol,?010, 647(1-3), 178-187.

[2]Shaik N, et al. Cell Physiol Biochem,?012, 30(6), 1517-1525.

[3]MacGregor TR, ZuWallack R, Rubano V, Castles MA, Dewberry H, Ghafouri M, Wood CC. Efficiency of Ipratropium Bromide and Albuterol Deposition in the Lung Delivered via a Soft Mist Inhaler or Chlorofluorocarbon Metered-Dose Inhaler. Clin Transl Sci. 2016 Apr;9(2):105-13.

[4]Schilero GJ, Hobson JC, Singh K, Spungen AM, Bauman WA, Radulovic M. Bronchodilator effects of ipratropium bromide and albuterol sulfate among subjects with tetraplegia. J Spinal Cord Med. 2018 Jan;41(1):42-47.

[5]Wang F, Zheng H, Zhang Y, Zhu H, Shi J, Luo Y, Zhang X, Mao H, Herth FJF, Luo F. Nebulized Ipratropium bromide protects against tracheal and bronchial secretion during bronchoscopy: A randomized controlled trial. Medicine (Baltimore). 2019 Nov;98(47):e17942.