Fenbufen is a non-selective non-steroidal anti-inflammatory drug (NSAID), used to treat acute and chronic painful conditions. Fenbufen at both doses (800 mg or 400 mg, oral) had apparent analgesic efficacy[3]. Fenbufen is a phenylalkanoic acid derivative with analgesic and anti-inflammatory activity. At a daily dosage of 600 mg, fenbufen is comparable with aspirin 3.6 g or indomethacin 75 mg in osteoarthritis[4]. Like clinically used nonsteroidal anti-inflammatory drugs, Fenbufen shows activity in a wide spectrum of laboratory tests in mice, rats, guinea pigs, and dogs. Fenbufen has a long duration of anti-inflammatory and analgesic activity. Mechanistic studies indicate that fenbufen has no intrinsic effect on cyclooxygenase activity, whereas its major metabolite, biphenylacetic acid, is a potent inhibitor of prostaglandin synthesis. Comparative studies in the type II collagen arthritis model indicate that the anti-inflammatory properties of fenbufen are more potent than those of a second nonsteroidal anti-inflammatory drug, sulindac[5].
Fenbufen/芬布芬 细胞实验
Cell Line
Concentration
Treated Time
Description
References
rat hippocampal CA1 pyramidal cells
20 μM
at least 30 minutes
To test the effect of Fenbufen on the amplitude of electrically evoked field potentials, results showed a 122.9% increase in amplitude at 20 μM concentration.
To test the effect of Fenbufen on the amplitude of electrically evoked field potentials, results showed a 119.2% increase in amplitude at 10 μM concentration.
To test the effect of Fenbufen on the amplitude of electrically evoked field potentials, results showed a 38.7% increase in amplitude at 5 μM concentration.
To test the effect of Fenbufen on the amplitude of electrically evoked field potentials, results showed a 1.7% increase in amplitude at 1 μM concentration.
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