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/ 环氧化酶 / Etofenamate/依托芬那酯

Etofenamate/依托芬那酯 {[allProObj[0].p_purity_real_show]}

货号：A208669

Etofenamate是一种非甾体抗炎药，用于治疗关节和肌肉疼痛。

Etofenamate/依托芬那酯 化学结构 CAS号：30544-47-9
Etofenamate/依托芬那酯 化学结构
CAS号：30544-47-9
Etofenamate/依托芬那酯 3D分子结构
CAS号：30544-47-9
Etofenamate/依托芬那酯 化学结构 CAS号：30544-47-9
Etofenamate/依托芬那酯 3D分子结构 CAS号：30544-47-9
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Etofenamate/依托芬那酯 纯度/质量文件 产品仅供科研

货号：A208669 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 COX ↓ COX-1 ↓ COX-2 ↓ 其他靶点 纯度
Piroxicam ✔ 98%
Salicylic acid ✔ 98%
Phenacetin ✔ 98%
Etodolac ✔ 99%
Flunixin meglumine ✔ 98%
Ibuprofen L-lysine ✔ 99%
Nabumetone ✔ 98%
Acemetacin ✔ 98%
Diflunisal ✔ 98%
Pranoprofen ✔ 98%
Ampiroxicam ✔ 98%
Meloxicam ✔ 98%
Sulindac ✔ 98%
Ketoprofen ✔ 98%
Mefenamic Acid ✔ 95%
Bromfenac sodium ✔ 98%
Oxaprozin ✔ 99%
Aspirin ✔ 99%
Nepafenac ✔ 98%
Zaltoprofen ✔ 99%
Salicin ✔ 98%
Suprofen ✔ 99%+
Xanthohumol ✔ 99%
Parecoxib ✔ 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

 		98%
Etoricoxib ✔ 99%
Niflumic Acid ✔ 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

 		99+%
Ibuprofen +

COX-1, IC50: 13 μM

 		+

COX-2, IC50: 370 μM

 		98%
Indomethacin ++

COX1, IC50: 0.28 μM

 		+

COX-2, IC50: 14 μM

 		97%
Lornoxicam ++++

COX-1, IC50: 5 nM

 		++++

COX-2, IC50: 8 nM

 		98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

 		+++

COX-2, IC50: 50 nM

 		99%
Rofecoxib ++++

COX-2, IC50: 18 nM

 		98%
Asaraldehyde ✔ 98%
Naproxen +

COX-1, IC50: 8.7 μM

 		+

COX-2, IC50: 5.2 μM

 		98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

 		+++

COX-2, IC50: 200 nM

 		98%
NS-398 ++

COX-2, IC50: 3.8 μM

 		95%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

 		+++

COX-2, IC50: 150 nM

 		98%+
Nimesulide +

COX-2, IC50: 26 μM

 		98%
Lumiracoxib ++

COX-1, Ki: 3 μM

 		+++

COX-2, Ki: 60 nM

 		99%
Rutaecarpine ✔ 95%
Celecoxib ++++

COX-2, IC50: 40 nM

 		98%
Carprofen ++++

canine COX2, IC50: 30 nM

 		98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

 		++

COX-2 (human), IC50: 3.50 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Etofenamate/依托芬那酯 生物活性

描述 Etofenamate, a non-steroid anti-inflammatory drug (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties[3]. Etofenamate is an effective therapeutic option for the management of musculoskeletal disorders, such as blunt traumas, lumbago or osteoarthrosis[4]. The single dose of 1 g etofenamate is effective in the management of acute pain[5]. Molecules like etofenamate have a bioavailability of >20% and evidence for accumulation in synovial tissues, with efficacy demonstrated as improvement in pain and function in real-life studies of OA (osteoarthritis) patients[6]. In vivo activity in the rat paw edema inflammation model showed that SLN hydrogels containing lower doses of etofenamate (8.3 times lower) and ibuprofen (16.6 times lower) produced similar effects compared to the commercial formulations, while decreasing edema and inflammatory cell infiltration, and causing no histological changes in the epidermis[7].

Etofenamate/依托芬那酯 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00530387 Dermatitis, Photocontact Not Applicable Completed - United Kingdom ... 展开 >> Photobiology Unit, Ninewells Hospital, Dundee, Angus, United Kingdom, DD1 9SY 收起 <<

Etofenamate/依托芬那酯 参考文献

[1]Fraga A, de Almeida M, et al. Intramuscular Etofenamate versus Diclofenac in the Relief of Renal Colic : A Randomised, Single-Blind, Comparative Study. Clin Drug Investig. 2003;23(11):701-6.

[2]Bender T, Bariska J, et al. Etofenamate levels in human serum and synovial fluid following iontophoresis. Arzneimittelforschung. 2001;51(6):489-92.

[3]Fraga A, de Almeida M, Moreira-da-Silva V, Sousa-Marques M, Severo L, Matos-Ferreira A, Campos-Pinheiro L, Reis M, Ribau U, Silveira P, Almeida L. Intramuscular Etofenamate versus Diclofenac in the Relief of Renal Colic : A Randomised, Single-Blind, Comparative Study. Clin Drug Investig. 2003;23(11):701-6

[4]Marinho ODS, Pereira A. Clinical Efficacy and Safety Profile of Topical Etofenamate in the Treatment of Patients with Musculoskeletal Disorders: A Systematic Review. Pain Ther. 2020 Dec;9(2):393-410

[5]Patiñio JL, Mejía SN, Ramos EQ. Efecto analgésico del etofenamato en el manejo de las lumbalgias agudas en urgencias [Etofenamate and the analgesic effect in the management of acute pain from spine in the emergency room]. Acta Ortop Mex. 2007 Sep-Oct;21(5):253-5. Spanish

[6]Rannou F, Pelletier JP, Martel-Pelletier J. Efficacy and safety of topical NSAIDs in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S18-21

[7]Mancini G, Gonçalves LMD, Marto J, Carvalho FA, Simões S, Ribeiro HM, Almeida AJ. Increased Therapeutic Efficacy of SLN Containing Etofenamate and Ibuprofen in Topical Treatment of Inflammation. Pharmaceutics. 2021 Mar 3;13(3):328

Etofenamate/依托芬那酯 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.54mL

2.71mL

1.35mL

27.08mL

5.42mL

2.71mL

Etofenamate/依托芬那酯 技术信息

CAS号30544-47-9
分子式C18H18F3NO4
分子量 369.33
SMILES Code OCCOCCOC(C1=C(C=CC=C1)NC2=CC=CC(C(F)(F)F)=C2)=O
MDL No. MFCD00242806
别名
运输蓝冰
InChI Key XILVEPYQJIOVNB-UHFFFAOYSA-N
Pubchem ID 35375
存储条件

In solvent -20°C:3-6个月-80°C:12个月
溶解方案

DMSO: 50 mg/mL(135.38 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(270.76 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: Etofenamate | 30544-47-9 | COX | Cyclooxygenase | COX Inhibitor | Immunology/Inflammation | COX | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Etofenamate/依托芬那酯 纯度/质量文件 | Etofenamate/依托芬那酯 亚型比较 | Etofenamate/依托芬那酯 生物活性 | Etofenamate/依托芬那酯 临床数据 | Etofenamate/依托芬那酯 参考文献 | Etofenamate/依托芬那酯 实验方案 | Etofenamate/依托芬那酯 技术信息

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