Inhibit PG-hydrolyzing activity of LytM1 and G-G endopeptidase
mBio. 2025 Apr 9;16(4):e0402724
Vibrio cholerae
10 µM
4 h
Significantly inhibit PG-hydrolyzing activity of Mpg orthologs
mBio. 2025 Apr 9;16(4):e0402724
Escherichia coli
10 µM
4 h
Significantly inhibit PG-hydrolyzing activity of Mpg orthologs
mBio. 2025 Apr 9;16(4):e0402724
Acinetobacter baumannii
10 µM
4 h
Significantly inhibit PG-hydrolyzing activity of Mpg orthologs
mBio. 2025 Apr 9;16(4):e0402724
3T3-L1 preadipocytes
5, 10, 20 μM
8 days
Chebulinic acid significantly inhibited the differentiation of 3T3-L1 preadipocytes into adipocytes and reduced lipid droplet accumulation in a concentration-dependent manner. 20 μM Chebulinic acid suppressed lipid accumulation by >60%.
Int J Mol Sci. 2022 Jan 13;23(2):865
LLC-PK1 cells
0, 12.5, 25, 50 µM
24 h
Evaluate the inhibitory effect of Chebulinic acid on PEDV replication, showing significant reductions in viral genome, viral protein, and titer.
Front Cell Infect Microbiol. 2025 Mar 18;15:1531415
CCL-81 cells
0, 12.5, 25, 50 µM
24 h
Evaluate the inhibitory effect of Chebulinic acid on PEDV replication, showing significant reductions in viral genome, viral protein, and titer.
Front Cell Infect Microbiol. 2025 Mar 18;15:1531415
Human synovial microvascular endothelial cells (HSMECs)
1.7 μM
To investigate the effects of Chebulinic acid on VEGF-induced phosphorylation of Erk1/2, p38 MAPK, and Akt. Results showed that Chebulinic acid significantly inhibited VEGF-induced phosphorylation of these signaling pathways.
Arthritis Res Ther. 2020 Nov 23;22(1):273
Helicobacter pylori ATCC 700392
16-32 μg/mL
6 h
Evaluated the anti-adhesive effect of Chebulinic acid on Helicobacter pylori, showing significant inhibition of bacterial adhesion at 16 or 32 μg/mL.
Front Microbiol. 2024 Oct 2;15:1416794
GES-1
64 μg/mL
24 h
Assessed the cytotoxicity of Chebulinic acid on GES-1 cells, showing no significant effect on cell viability at 64 μg/mL.
Front Microbiol. 2024 Oct 2;15:1416794
HeLa cells
100 µM
90 min
Evaluate the effect of Chebulinic acid on the respiratory capacity of HeLa cells, showing no significant inhibition of respiratory capacity.
Theranostics. 2021 Mar 5;11(11):5077-5091
Chebulinic acid/诃子林鞣酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
DBA/1J mice
Collagen-induced arthritis (CIA) model
Oral gavage
50 mg/kg
Once daily for 14 consecutive days
To evaluate the effects of Chebulinic acid on disease progression in CIA mice. Results showed that Chebulinic acid significantly inhibited paw swelling, decreased the mean articular index and joint pathology scores, and did not increase blood pressure.
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