Voreloxin HCl | AG 7352 Hydrochloride | Topoisomerase Inhibitor

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Voreloxin HCl {[allProObj[0].p_purity_real_show]}

货号：A405214 同义名： AG 7352 Hydrochloride; Vosaroxin Hydrochloride

Voreloxin HCl是一种新型拓扑异构酶 II 抑制剂，能够诱导 DNA 双链断裂，阻滞 G2 期并引发细胞凋亡，具有抗肿瘤活性。

Voreloxin HCl 化学结构
CAS号：175519-16-1

Voreloxin HCl 3D分子结构
CAS号：175519-16-1

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Voreloxin HCl 纯度/质量文件产品仅供科研

货号：A405214 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

拓扑异构酶亚型比较

产品名称	Topo I ↓ ↑	Topo II ↓ ↑	Topo IV ↓ ↑	Topoisomerase ↓ ↑	其他靶点	纯度
Ellagic acid	✔					98%
β-Lapachone	✔					99%+
(s)-10-hydroxycamptothecin	✔					98+%
Camptothecin	++ Topo I, IC50: 0.68 μM					98%
Betulinic acid	++ Eukaryotic topoisomerase I, IC50: 5 μM					98%
Topotecan	++++ Topo I (MCF-7 Luc cells), IC50: 13 nM Topo I (DU-145 Luc cells), IC50: 2 nM					98%
Irinotecan HCl Trihydrate	✔					98%
SN-38	✔					98%
Levofloxacin hydrate		✔				98%
Dexrazoxane		✔				99%+
Ofloxacin		✔				98+%
Enoxacin		✔				99%+
Flumequine		+ Topo II, IC50: 15 μM				98%
Levofloxacin		✔				97%
Etoposide		✔				98%
Pefloxacin mesylate dihydrate		✔				99.5%
Marbofloxacin		✔				98+%
Voreloxin HCl		✔				98%
Mitoxantrone 2HCl		✔			PKC	98%
Nalidixic acid		✔				98%
Doxorubicin		✔				97%
Novobiocin sodium		✔				95%
Amonafide		✔				99%+
Pirarubicin		✔				98%+
Idarubicin HCl		+++ Topo II (MCF-7 cells), IC50: 3.3 ng/mL				99%+
Genistein		✔			EGFR	98%
Teniposide		✔				98%
Moxifloxacin		✔				98%
Ciprofloxacin			✔			98%
Clinafloxacin			✔			99%
Gatifloxacin				✔		98%
Daunorubicin HCl				+++ DNA synthesis, Ki: 20 nM		98%
Epirubicin HCl				✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Voreloxin HCl 生物活性

靶点	Topo II
描述	Voreloxin hydrochloride is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.

Voreloxin HCl 细胞实验

Cell Line Human cells Yeast cells MOLT-4 cells REH cells K562 cells MOLM-14 cells	Concentration	Treated Time	Description	References
Human cells	100 μM	3 days	Screening for human cells resistant to Voreloxin	Nucleic Acids Res. 2019 Sep 5;47(15):8163-8179.
Yeast cells	100 μM	3 days	Screening for yeast cells resistant to Voreloxin	Nucleic Acids Res. 2019 Sep 5;47(15):8163-8179.
MOLT-4 cells	300 nM	24 hours	To evaluate the anti-proliferative effects of the combination of VX-11e and voreloxin on leukemia cells, showing synergistic effects in MOLT-4 cells.	Apoptosis. 2019 Dec;24(11-12):849-861.
REH cells	22 nM	24 hours	To evaluate the anti-proliferative effects of the combination of VX-11e and voreloxin on leukemia cells, showing synergistic effects in REH cells.	Apoptosis. 2019 Dec;24(11-12):849-861.
K562 cells	50 nM	24 hours	To evaluate the anti-proliferative effects of the combination of VX-11e and voreloxin on leukemia cells, showing additive, antagonistic, and one synergistic effect in K562 cells.	Apoptosis. 2019 Dec;24(11-12):849-861.
MOLM-14 cells	160 nM	24 hours	To evaluate the anti-proliferative effects of the combination of VX-11e and voreloxin on leukemia cells, showing synergistic effects in MOLM-14 cells.	Apoptosis. 2019 Dec;24(11-12):849-861.

Voreloxin HCl 参考文献

[1]Hoch U, Lynch J, et al. Voreloxin, formerly SNS-595, has potent activity against a broad panel of cancer cell lines and in vivo tumor models. Cancer Chemother Pharmacol. 2009 Jun;64(1):53-65.

[2]Tsuzuki Y, Tomita K, et al. Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 2. J Med Chem. 2004 Apr 8;47(8):2097-109.

Voreloxin HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.42mL

2.28mL

1.14mL

22.84mL

4.57mL

2.28mL

Voreloxin HCl 技术信息

CAS号	175519-16-1
分子式	C₁₈H₂₀ClN₅O₄S
分子量	437.9
SMILES Code	[H]Cl.O=C(C1=CN(C2=NC=CS2)C3=C(C=CC(N4C[C@H](OC)[C@@H](NC)C4)=N3)C1=O)O
MDL No.	MFCD13185156

别名	AG 7352 Hydrochloride; Vosaroxin Hydrochloride; Vosaroxin; SNS-595 Hydrochloride; Voreloxin Hydrochloride
运输	蓝冰

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, store in freezer, under -20°C

溶解方案

细胞实验：

DMSO: 2 mg/mL(4.57 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 2 mg/mL(4.57 mM)，配合低频超声，并水浴加热至45℃助溶

动物实验：配制的工作液建议现用现配，短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

Voreloxin HCl {[allProObj[0].p_purity_real_show]}

Voreloxin HCl 纯度/质量文件产品仅供科研

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Voreloxin HCl 生物活性

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Voreloxin HCl 技术信息

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Voreloxin HCl {[allProObj[0].p_purity_real_show]}

Voreloxin HCl 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Voreloxin HCl 质控信息

Voreloxin HCl 生物活性

Voreloxin HCl 细胞实验

Voreloxin HCl 参考文献

Voreloxin HCl 实验方案

Voreloxin HCl 技术信息

最近浏览的产品

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临床研究

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