Valrubicin是一种化疗药物，其对TPA-和PDBu诱导的PKC激活具有0.85和1.25 μM的IC50值，具有抗癌和抗炎性能。

Banoxantrone dihydrochloride是一种新型生物还原剂，可以还原为稳定的 DNA 亲和化合物 AQ4。AQ4 是一种有效的拓扑异构酶 II 抑制剂。

Exatecan (DX-8951) 是一种具有 2.2 μM (0.975 μg/mL) IC50 的 DNA 拓扑异构酶 I 抑制剂，用于癌症研究。

Camptothecin (CPT) 是一种生物碱，作为 DNA 拓扑异构酶 I (Topo I) 抑制剂，IC50 为 679 nM。它对结直肠癌、乳腺癌、肺癌和卵巢癌表现出强效的抗肿瘤活性，并通过改变人类癌细胞中的微小 RNA (miRNA) 表达模式来调节缺氧诱导因子 1α (HIF-1α) 活性。

Gepotidacin (GSK2140944) 是一种新型三氮杂蒽二酮类细菌 II 型拓扑异构酶抑制剂。

Trovafloxacin mesylate 是一种广谱喹诺酮类抗生素，对革兰氏阳性、革兰氏阴性和厌氧菌有效。Trovafloxacin mesylate 通过阻断 DNA 拓扑异构酶 IV 和 DNA促旋酶 的活性发挥作用。它也是一种有效、选择性、口服活性 Pannexin 1 通道（PANX1）抑制剂，对 PANX1 内向电流的 IC50 为 4 μM。

Topotecan HCl（SKF 104864A Hydrochloride）作为一种拓扑异构酶I抑制剂，具有强效抗肿瘤活性。

Irinotecan hydrochloride是一种拓扑异构酶I抑制剂，主要用于治疗结肠癌和直肠癌。

Irinotecan HCl Trihydrate是一种具有抗肿瘤活性的拓扑异构酶 I 抑制剂。

Finafloxacin HCl, an 8-cyano subclass of fluoroquinolone, has demonstrated potent antibacterial activity in a range of in vitro and in vivo models against Gram-negative and Gram-positive bacterial isolates.

Balofloxacin, a quinolone antibiotic, can interfer with DNA gyrase and inhibit the synthesis of bacterial DNA.

Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.

7-Ethylcamptothecin is derived from Camptothecin with anti-cancer activity against various murine tumors through inhibition of Topo I (topoisomerase).

Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication.

Moxifloxacin HCl is a fluoroquinolone antibiotic agent.

A choleretic.