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货号 产品名 纯度
A326372 Gimatecan

98%
A1671100 Pixantrone HCl

98%+
A405309 12-Ethyl-9-hydroxycamptothecin

98%+
A166750 Mitoxantrone dihydrochloride/盐酸米托蒽醌

Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity.

98%
A472083 Amsacrine/安吖啶

Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity.

99%+
A724668 Banoxantrone 2HCl

Banoxantrone dihydrochloride是一种新型生物还原剂,可以还原为稳定的 DNA 亲和化合物 AQ4。AQ4 是一种有效的拓扑异构酶 II 抑制剂。

98%
A951815 β-Lapachone/β-拉帕醌

β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC50=0.44 μM).

99%+
A774318 Finafloxacin hydrochloride/盐酸非那沙星

Finafloxacin HCl, an 8-cyano subclass of fluoroquinolone, has demonstrated potent antibacterial activity in a range of in vitro and in vivo models against Gram-negative and Gram-positive bacterial isolates.

95%
A1671830 MrgprX2 antagonist-8

98%
A105718 Balofloxacin/巴洛沙星

Balofloxacin, a quinolone antibiotic, can interfer with DNA gyrase and inhibit the synthesis of bacterial DNA.

98%
A102576 Teniposide/替尼泊苷

Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine.

98%
A148164 Daunorubicin HCl/盐酸柔红霉素

Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis.

98%
A510593 Ofloxacin/氧氟沙星

Ofloxacin, a fluoroquinolone compound, can inhibit bacterial DNA gyrase.

98+%
A580248 Amsacrine HCl/安吖啶盐酸盐

Amsacrine HCl is an antineoplastic agent which can intercalate into the DNA of tumor cells.

98+%
A783659 Nalidixic acid sodium salt/萘啶酮酸

Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.

98%
A154645 7-Ethylcamptothecin/7-乙基喜树碱

7-Ethylcamptothecin is derived from Camptothecin with anti-cancer activity against various murine tumors through inhibition of Topo I (topoisomerase).

99%
A140688 Nadifloxacin/那氟沙星

Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication.

98%
A352968 Marbofloxacin/麻保沙星

Marbofloxacin can inhibit DNA-gyrase and it is an antibiotic.

98+%
A208061 Ciprofloxacin/环丙沙星

Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.

98%
A250011 Moxifloxacin HCl/盐酸莫西沙星

Moxifloxacin HCl is a fluoroquinolone antibiotic agent.

98%
产品名 Topo I Topo II Topo IV Topoisomerase 其他靶点 纯度
Ellagic acid 98%
β-Lapachone 99%+
(s)-10-hydroxycamptothecin 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

98%
Topotecan ++++

Topo I (MCF-7 Luc cells), IC50: 13 nM

Topo I (DU-145 Luc cells), IC50: 2 nM

99%+
Irinotecan HCl Trihydrate 98%
SN-38 98%
Levofloxacin hydrate 98%
Dexrazoxane 99%+
Ofloxacin 98+%
Enoxacin 99%+
Flumequine +

Topo II, IC50: 15 μM

98%
Levofloxacin 97%
Etoposide 98%
Pefloxacin mesylate dihydrate 99+%
Marbofloxacin 98+%
Voreloxin HCl 98%
Mitoxantrone dihydrochloride PKC 98%
Nalidixic acid 98%
Doxorubicin 98%
Novobiocin sodium 98%
Amonafide 99%+
Pirarubicin 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

99%+
Genistein EGFR 98%
Teniposide 98%
Moxifloxacin 98%
Ciprofloxacin 98%
Clinafloxacin 98%
Gatifloxacin 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

98%
Epirubicin HCl 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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