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货号 产品名 纯度
A724668 现货 Banoxantrone 2HCl

Banoxantrone dihydrochloride是一种新型生物还原剂,可以还原为稳定的 DNA 亲和化合物 AQ4。AQ4 是一种有效的拓扑异构酶 II 抑制剂。

98%
A392519 现货 Gepotidacin

Gepotidacin (GSK2140944) 是一种新型三氮杂蒽二酮类细菌 II 型拓扑异构酶抑制剂。

99%
A122669 现货 Topotecan HCl/拓扑替康盐酸盐

Topotecan HCl(SKF 104864A Hydrochloride)作为一种拓扑异构酶I抑制剂,具有强效抗肿瘤活性。

98%
A191480 现货 Valrubicin/戊柔比星

Valrubicin是一种化疗药物,其对TPA-和PDBu诱导的PKC激活具有0.85和1.25 μM的IC50值,具有抗癌和抗炎性能。

99%+
A619128 现货 Exatecan/依喜替康

Exatecan (DX-8951) 是一种具有 2.2 μM (0.975 μg/mL) IC50DNA 拓扑异构酶 I 抑制剂,用于癌症研究。

98%
A159794 现货 Camptothecin/喜树碱

Camptothecin (CPT) 是一种生物碱,作为 DNA 拓扑异构酶 I (Topo I) 抑制剂,IC50 为 679 nM。它对结直肠癌、乳腺癌、肺癌和卵巢癌表现出强效的抗肿瘤活性,并通过改变人类癌细胞中的微小 RNA (miRNA) 表达模式来调节缺氧诱导因子 1α (HIF-1α) 活性。

98%
A357594 现货 Trovafloxacin mesylate/曲伐沙星甲磺酸盐

Trovafloxacin mesylate 是一种广谱喹诺酮类抗生素,对革兰氏阳性、革兰氏阴性和厌氧菌有效。Trovafloxacin mesylate 通过阻断 DNA 拓扑异构酶 IV 和 DNA促旋酶 的活性发挥作用。它也是一种有效、选择性、口服活性 Pannexin 1 通道(PANX1)抑制剂,对 PANX1 内向电流的 IC50 为 4 μM。

98%
A309111 现货 Irinotecan hydrochloride/伊立替康盐酸盐

Irinotecan hydrochloride是一种拓扑异构酶I抑制剂,主要用于治疗结肠癌和直肠癌。

98%
A244220 现货 Irinotecan HCl Trihydrate/盐酸依立替康三水合物

Irinotecan HCl Trihydrate是一种具有抗肿瘤活性的拓扑异构酶 I 抑制剂。

98%
A326372 现货 Gimatecan

98%
A1671100 现货 Pixantrone HCl

98%+
A405309 现货 12-Ethyl-9-hydroxycamptothecin

98%+
A166750 现货 Mitoxantrone dihydrochloride/盐酸米托蒽醌

Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity.

98%
A472083 现货 Amsacrine/安吖啶

Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity.

99%+
A951815 现货 β-Lapachone/β-拉帕醌

β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC50=0.44 μM).

99%+
A774318 现货 Finafloxacin hydrochloride/盐酸非那沙星

Finafloxacin HCl, an 8-cyano subclass of fluoroquinolone, has demonstrated potent antibacterial activity in a range of in vitro and in vivo models against Gram-negative and Gram-positive bacterial isolates.

95%
A1671830 现货 MrgprX2 antagonist-8

98%
A105718 现货 Balofloxacin/巴洛沙星

Balofloxacin, a quinolone antibiotic, can interfer with DNA gyrase and inhibit the synthesis of bacterial DNA.

98%
A102576 现货 Teniposide/替尼泊苷

Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine.

98%
A148164 现货 Daunorubicin HCl/盐酸柔红霉素

Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis.

98%
产品名 Topo I Topo II Topo IV Topoisomerase 其他靶点 纯度
Ellagic acid 98%
β-Lapachone 99%+
(s)-10-hydroxycamptothecin 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

98%
Topotecan ++++

Topo I (MCF-7 Luc cells), IC50: 13 nM

Topo I (DU-145 Luc cells), IC50: 2 nM

99%+
Irinotecan HCl Trihydrate 98%
SN-38 98%
Levofloxacin hydrate 98%
Dexrazoxane 99%+
Ofloxacin 98+%
Enoxacin 99%+
Flumequine +

Topo II, IC50: 15 μM

98%
Levofloxacin 97%
Etoposide 98%
Pefloxacin mesylate dihydrate 99+%
Marbofloxacin 98+%
Voreloxin HCl 98%
Mitoxantrone dihydrochloride PKC 98%
Nalidixic acid 98%
Doxorubicin 98%
Novobiocin sodium 98%
Amonafide 99%+
Pirarubicin 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

99%+
Genistein EGFR 98%
Teniposide 98%
Moxifloxacin 98%
Ciprofloxacin 98%
Clinafloxacin 98%
Gatifloxacin 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

98%
Epirubicin HCl 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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