Levofloxacin hydrate是一种抗生素，针对革兰氏阴性菌，通过抑制细菌 DNA 回旋酶的超螺旋活性来阻止 DNA 复制。
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Limited Quantity
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Levofloxacin (Hemihydrate) is a fluoroquinolone antibiotic and is the optical S-(-) isomer of the racemic drug substance ofloxacin. It has a broad spectrum of in vitro activity against Gram-positive and Gram-negative bacteria, as well as certain other pathogens such as Mycoplasma, Chlamydia, Legionella and Mycobacteria spp. Plasma concentrations in healthy volunteers reach a mean peak drug plasma concentration (Cmax) of approximately 2.8 and 5.2 mg/L within 1 to 2 hours after oral administration of levofloxacin 250 and 500 mg tablets, respectively[3]. In stable COPD (chronic obstructive pulmonary disease), levofloxacin treatment causes a short-term reduction in bacterial load[4]. Levofloxacin was found to significantly improve the clinical and microbiological parameters in CP (chronic periodontitis) individuals[5]. A 30-day course of levofloxacin does not significantly improve BK viral load reduction or allograft function when used in addition to overall reduction of immunosuppression[6].
Levofloxacin hydrate/左氧氟沙星半水合物 细胞实验
Cell Line
Concentration
Treated Time
Description
References
ZF4 cells
1 × 10^6 CFU/ml
3 hours
To test the effect of Lev-S and Lev-R V. alginolyticus on promoter activity in ZF4 cells
Microb Biotechnol. 2020 Jul;13(4):1213-1227.
Mycobacterium tuberculosis H37Ra (extracellular)
0.125 mg/L (1xMIC)
7 days
To evaluate the bactericidal effect of levofloxacin against extracellular Mycobacterium tuberculosis. Results showed maximal kill (Emax) >7 log10 CFU/mL.
Clin Infect Dis. 2018 Nov 28;67(suppl_3):S293-S302.
THP-1 cells
0.125 mg/L (1xMIC)
7 days
To evaluate the bactericidal effect of levofloxacin against intracellular Mycobacterium tuberculosis. Results showed that the killing effect was 2 log10 CFU/mL lower than against extracellular bacilli.
Clin Infect Dis. 2018 Nov 28;67(suppl_3):S293-S302.
Elizabethkingia anophelis
0.5 to 128 mg/L
72 hours
To determine the minimum inhibitory concentration (MIC) and mutant prevention concentration (MPC) of levofloxacin against Elizabethkingia anophelis and investigate its resistance mechanisms
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