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SN-38 {[allProObj[0].p_purity_real_show]}

货号：A366170 同义名： 伊立替康杂质B / 7-Ethyl-10-hydroxycamptothecin; NK 012

SN-38是 CPT-11 的活性代谢物，通过抑制 DNA 拓扑异构酶 I 和 DNA 合成引发 DNA 单链断裂，IC50 分别为 0.077 μM（DNA 合成）和 1.3 μM（RNA 合成）。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
SN-38 化学结构 CAS号：86639-52-3
SN-38 化学结构
CAS号：86639-52-3
SN-38 3D分子结构
CAS号：86639-52-3
SN-38 化学结构 CAS号：86639-52-3
SN-38 3D分子结构 CAS号：86639-52-3
规格 价格 会员价 库存 数量
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SN-38 纯度/质量文件 产品仅供科研

货号：A366170 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
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产品名称 Topo I ↓ Topo II ↓ Topo IV ↓ Topoisomerase ↓ 其他靶点 纯度
Ellagic acid ✔ 98%
β-Lapachone ✔ 99%+
(s)-10-hydroxycamptothecin ✔ 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

 		98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

 		98%
Topotecan ++++

Topo I (MCF-7 Luc cells), IC50: 13 nM

Topo I (DU-145 Luc cells), IC50: 2 nM

 		98%
Irinotecan HCl Trihydrate ✔ 98%
SN-38 ✔ 98%
Levofloxacin hydrate ✔ 98%
Dexrazoxane ✔ 99%+
Ofloxacin ✔ 98+%
Enoxacin ✔ 99%+
Flumequine +

Topo II, IC50: 15 μM

 		98%
Levofloxacin ✔ 97%
Etoposide ✔ 98%
Pefloxacin mesylate dihydrate ✔ 99.5%
Marbofloxacin ✔ 98+%
Voreloxin HCl ✔ 98%
Mitoxantrone 2HCl ✔ PKC 98%
Nalidixic acid ✔ 98%
Doxorubicin ✔ 97%
Novobiocin sodium ✔ 95%
Amonafide ✔ 99%+
Pirarubicin ✔ 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

 		99%+
Genistein ✔ EGFR 98%
Teniposide ✔ 98%
Moxifloxacin ✔ 98%
Ciprofloxacin ✔ 98%
Clinafloxacin ✔ 99%
Gatifloxacin ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Epirubicin HCl ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

SN-38 生物活性

靶点

  • Topo I
描述 SN-38, derived from the Topoisomerase I inhibitor Irinotecan, serves as its active metabolite. SN-38 impedes DNA and RNA synthesis, with IC50 values of 0.077 μM and 1.3 μM, respectively [1][2][3][4].
体内研究

SN-38 is the active and toxic metabolite of the anticancer prodrug Irinotecan. At 30 minutes post-administration, Irinotecan plasma concentrations in Slco1a/1b(−/−) mice are 1.9-fold higher compared to wild-type mice (1.89 vs. 1.01 μM, respectively), while SN-38 plasma concentrations in Slco1a/1b(−/−) mice are 8-fold higher than in wild-type mice (0.4 μg/mL vs. 0.05 μg/mL, respectively). The overall plasma exposure [AUC(5-240)] of Irinotecan is 1.7-fold higher in Oatp1a/1b knockout mice compared to wild-type mice (209.8±6.7 vs. 120.9±4.4 μM/min; P<0.01), and 2.9-fold higher for SN-38 (50±2.9 vs. 12±2 μM/min; P<0.001) [3].
体外研究

The IC50 values for LoVo, HCT116, and HT29 cell lines are 20 nM, 50 nM, and 130 nM, respectively. In all three SN-38 resistant cell lines, Top1 activity persists even in the presence of elevated concentrations of SN-38 [2].

SN-38 细胞实验

Cell Line
Concentration Treated Time Description References
CHLA-32 cells 1 μM 24 hours UNC2025 suppressed SN-38-induced Akt and ERK signaling activation Nat Commun. 2024 Jun 21;15(1):5292.
EWS894 cells 1 μM 24 hours UNC2025 suppressed SN-38-induced Akt and ERK signaling activation Nat Commun. 2024 Jun 21;15(1):5292.
SK-N-MC cells 1 μM 24 hours UNC2025 suppressed SN-38-induced Akt and ERK signaling activation Nat Commun. 2024 Jun 21;15(1):5292.
CHLA-10 cells 1 μM 24 hours UNC2025 suppressed SN-38-induced Akt and ERK signaling activation Nat Commun. 2024 Jun 21;15(1):5292.
TC-32 cells 1 μM 24 hours UNC2025 suppressed SN-38-induced Akt and ERK signaling activation Nat Commun. 2024 Jun 21;15(1):5292.
TC-71 cells 1 μM 24 hours UNC2025 suppressed SN-38-induced Akt and ERK signaling activation Nat Commun. 2024 Jun 21;15(1):5292.
MHH-ES-1 cells 1 μM 24 hours UNC2025 suppressed SN-38-induced Akt and ERK signaling activation Nat Commun. 2024 Jun 21;15(1):5292.
A673 cells 1 μM 24 hours UNC2025 suppressed SN-38-induced Akt and ERK signaling activation Nat Commun. 2024 Jun 21;15(1):5292.
TC-32 1 μM 24 hours SN-38 treatment increased Akt-pT308 and ERK-p42/p44 signals Nat Commun. 2024 Jun 21;15(1):5292
TC-71 1 μM 24 hours SN-38 treatment increased Akt-pT308 and ERK-p42/p44 signals Nat Commun. 2024 Jun 21;15(1):5292
MHH-ES-1 1 μM 24 hours SN-38 treatment increased Akt-pT308 and ERK-p42/p44 signals Nat Commun. 2024 Jun 21;15(1):5292
A673 1 μM 24 hours SN-38 treatment increased Akt-pT308 and ERK-p42/p44 signals Nat Commun. 2024 Jun 21;15(1):5292
SNU-5 100 nM and 10 μM 72 h SN-38 inhibited SNU-5 cell proliferation by 51.1% and 84.8% Mol Cancer Ther. 2022 Jul 5;21(7):1149-1159.
MKN-45 100 nM and 10 μM 72 h SN-38 inhibited MKN-45 cell proliferation by 43.3% and 83.4% Mol Cancer Ther. 2022 Jul 5;21(7):1149-1159.
KATO-III 100 nM and 10 μM 72 h SN-38 inhibited KATO-III cell proliferation by 31.7% and 65.6% Mol Cancer Ther. 2022 Jul 5;21(7):1149-1159.

SN-38 动物研究

Dose Rat: 2 mg/kg[3] (i.v.); 40 mg/kg (p.o.) Mice: 5 mg/kg- 75 mg/kg[4] (i.v.)
Administration i.v., p.o.
Pharmacokinetics
Animal Mice[4]
Dose 5 mg/kg
Administration i.v.
p.o.
Cmax 647 ng/ml (i.v.)
30 ng/ml (p.o.)
AUC0→∞ 279 ng·h/ml (i.v.)
86 ng·h/ml (p.o.)
Tmax 1 h (p.o.)

SN-38 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.74mL

2.55mL

1.27mL

25.48mL

5.10mL

2.55mL

SN-38 技术信息

CAS号86639-52-3
分子式C22H20N2O5
分子量 392.4
SMILES Code O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC(O)=CC=C5N=C4C3=C2)=O
MDL No. MFCD00871873
别名 伊立替康杂质B ;7-Ethyl-10-hydroxycamptothecin; NK 012; irinotecan metabolite.; 10-hydroxy-7-ethylcamptothecin; 7-ethyl-10-hydroxy-20(S)-Camptothecin
运输蓝冰
InChI Key FJHBVJOVLFPMQE-QFIPXVFZSA-N
Pubchem ID 104842
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 25 mg/mL(63.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: SN-38 | 7-Ethyl-10-hydroxycamptothecin;NK 012;irinotecan metabolite.;10-hydroxy-7-ethylcamptothecin;7-ethyl-10-hydroxy-20(S)-Camptothecin | 伊立替康杂质B | Apoptosis Inducer | Anti-tumor | Topoisomerase I Inhibitor | DNA Topoisomerase II Inhibitor | Topoisomerase | AmBeed-信号通路专用抑制剂 | SN-38 纯度/质量文件 | SN-38 亚型比较 | SN-38 生物活性 | SN-38 动物研究 | SN-38 实验方案 | SN-38 技术信息

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