Etoposide | VP-16;VP-16-213;Demethyl Epipodophyllotoxin Ethylidine Glucoside. epipodophyllotoxin. US brand names: Toposar. VePesid. Foreign brand name: Lastet. Abbreviation: EPEG Code names: VP16;VP-16-123;NSC 141540;EPE | 依托泊甘 | Apoptosis Inducer | Drug Standard | DNA Topoisomerase II Inhibitor | Topoisomerase

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

A549		Growth Inhibition Assay	48 h	IC50=241.9 ± 31.23 μM	24996136
A549		Growth Inhibition Assay	48 h	IC50=139.54 ± 7.05 μM	24793877
BGC-823		Growth Inhibition Assay	48 h	IC50=43.74 ± 5.13 μM	24793877
Caco2	0.5-2.5 μM	Growth Inhibition Assay	48 h	IC50=7.26 ± 1.68 μM	25746763
CAL27		Growth Inhibition Assay	24 h	IC50=52.1 ± 1.09 μM	25220729
CAL27		Growth Inhibition Assay	48 h	IC50=18.24 ± 1.15 μM	25220729
CAL27		Growth Inhibition Assay	72 h	IC50=4.27 ± 1.14 μM	25220729
COLO 205	0.5-2.5 μM	Growth Inhibition Assay	48 h	IC50=1.61 ± 0.02 μM	25746763
DOHH-2		Growth Inhibition Assay	24 h	IC50＞100 μM	25048236
DOHH-2		Growth Inhibition Assay	48 h	IC50=19.9 μM	25048236
DOHH-2		Growth Inhibition Assay	72 h	IC50=5 μM	25048236
DU145		Growth Inhibition Assay		IC50=2.28 ± 0.04 μM	25603122
DU145	10-100 μM	Apoptosis Assay	8 h	induces cell death significantly in a very low concentration	25149681
DU145	10-100 μM	Function Assay	2 h	increases the pCHK1 expression and decreases the pCHK1 expression in a dose-dependent manner	25149681
DU145 stem-like	10-100 μM	Apoptosis Assay	8 h	induces cell death in a dose-dependent manner	25149681
DU145 stem-like	10-100 μM	Function Assay	2 h	increases the pCHK1 expression and decreases the pCHK1 expression in a dose-dependent manner	25149681
FaDu		Growth Inhibition Assay	24 h	IC50=25.89 ± 1.13 μM	25220729
FaDu		Growth Inhibition Assay	48 h	IC50=6.43 ± 1.13 μM	25220729
FaDu		Growth Inhibition Assay	72 h	IC50=5.02 ± 1.15 μM	25220729
HCT116	0.5-2.5 μM	Growth Inhibition Assay	48 h	IC50=1.73 ± 0.21 μM	25746763
HCT15		Growth Inhibition Assay		IC50=0.81 ± 0.01 μM	25603122
HD-MY-Z		Growth Inhibition Assay	24/48/72 h	IC50＞100 μM	25048236
HEK293		Growth Inhibition Assay		IC50=7.14 ± 0.36 μM	25603122
HEK293T	1-5 μM	Growth Inhibition Assay	48 h	IC50=2.42 ± 0.05 μM	25746763
HeLa		Growth Inhibition Assay	72 h	IC50=3.9 ± 2.3 μM	25486219
HeLa		Growth Inhibition Assay		GI50=0.64 ± 0.4 μM	24953821
HeLa		Growth Inhibition Assay	48 h	IC50=4.71 ± 1.4 μM	24953027
HeLa		Growth Inhibition Assay	48 h	IC50=209.90 ± 13.42 μM	24793877
Hep3B	10 μM	Function Assay	48 h	reduces the enhancing effect of BMP-6	25633564
Hep3B	0.1-10 μM	Function Assay	24 h	suppresses the expression of hepcidin mRNA	25633564
HepG2		Growth Inhibition Assay		IC50=30.16 ± 0.50 μM	25078311
HepG2		Growth Inhibition Assay	48 h	IC50=13.65 ± 0.92 μM	24996136
HH		Growth Inhibition Assay	24 h	IC50=104.7 μM	25048236
HH		Growth Inhibition Assay	48 h	IC50=48.6 μM	25048236
HH		Growth Inhibition Assay	72 h	IC50=14.7 μM	25048236
HK-2		Growth Inhibition Assay	48 h	IC50=9.17 ± 1.58 μM	24793877
HL-60		Growth Inhibition Assay	72 h	IC50=0.12 μM	24993014
HL-60[R]		Growth Inhibition Assay	72 h	IC50=3.12 μM	24993014
HT1080	1-100 μM	Growth Inhibition Assay	4/24/48 h	induces cell death significantly in a very low concentration	25078064
HT1080	0.0001-100 μM	Function Assay	1-24 h	induces p-p53(ser15) in both time- and concentration-dependent manner	25078064
HT1080	0.0001-100 μM	Growth Inhibition Assay	24 h	causes an increase in the number of cells in G2/M, while decreasing S and G1 phase cells	25078064
HT-29	0.5-2.5 μM	Growth Inhibition Assay	48 h	IC50=7.2 ± 1.04 μM	25746763
HT-29		Growth Inhibition Assay	48 h	IC50=21.45 ± 3.87 μM	24953027
HuT-78		Growth Inhibition Assay	24 h	IC50=9.3 μM	25048236
HuT-78		Growth Inhibition Assay	48 h	IC50=4.3 μM	25048236
HuT-78		Growth Inhibition Assay	72 h	IC50=4.2 μM	25048236
Jurkat		Growth Inhibition Assay	72 h	IC50=1.2 ± 1.5 μM	25486219
K/VP.5		Growth Inhibition Assay	72 h	IC50=4.9 μM	25282653
K562		Growth Inhibition Assay	72 h	IC50=0.29 μM	25282653
Kelly		Growth Inhibition Assay		IC50=0.12 ± 0.01 μM	25960282
Kelly	0-10 μM	Growth Inhibition Assay	72 h	IC50=1.518 μM	25008900
KellyCis83		Growth Inhibition Assay		IC50=0.16 ± 0.02 μM	25960282
MCF 7BMI1	10-100 μM	Function Assay	2 h	induces production of γH2AX	25088203
MCF7	5-100 μM	Growth Inhibition Assay	7 d	inhibits cell growth in a dose-dependent manner	25472619
MCF7		Growth Inhibition Assay	48 h	IC50=81.09 ± 14.21 μM	24996136
MCF-7		Growth Inhibition Assay	72 h	IC50=10.9 ± 2.1 μM	25486219
MCF-7		Growth Inhibition Assay	48 h	IC50=7.2 ± 0.8 μM	25216378
MCF-7		Growth Inhibition Assay		GI50=0.25 ± 0.1 μM	24953821
MCF-7		Growth Inhibition Assay	48 h	IC50=23.9 ± 0.3 μM	24953027
MCF7 BMI1	10-100 μM	Function Assay	2 h	ETOP induces ATM activation	25088203
MCF7 EV	10-100 μM	Function Assay	2 h	induces production of γH2AX	25088203
MCF7 EV	10-100 μM	Function Assay	2 h	ETOP induces ATM activation	25088203
MDA-MB-231		Growth Inhibition Assay	72 h	IC50=21.2 ± 4.2 μM	25486219
MDA-MB-231		Growth Inhibition Assay	48 h	IC50=12.8 ± 1.0 μM	25216378
MDA-MB-231		Growth Inhibition Assay	48 h	IC50=24.22 ± 2.94 μM	24953027
MDA-MB-453		Growth Inhibition Assay	48 h	IC50=12.5 ± 0.85 μM	24953027
ME 180		Growth Inhibition Assay	48 h	IC50=8.9 ± 0.3 μM	24953027
MIAPACA		Growth Inhibition Assay		GI50=1.3 ± 0.03 μM	24953821
MKL-1	10-1000 nM	Function Assay	4 d	induces the induction of MHC-I expression	25116754
MO59J		Growth Inhibition Assay	7 d	IC50=0.1 μM	24953561
MO59K		Growth Inhibition Assay	7 d	IC50=0.17 μM	24953561
MOLT-3		Growth Inhibition Assay		IC50=0.051 ± 0.002 μM	25078311
NSCs	0.01-300 μM	Growth Inhibition Assay	48 h	IC50=0.3-3 μM	25119185
OPM-2		Growth Inhibition Assay	24 h	IC50=24.1 μM	25048236
OPM-2		Growth Inhibition Assay	48 h	IC50=4 μM	25048236
OPM-2		Growth Inhibition Assay	72 h	IC50=1.3 μM	25048236
PC-3		Growth Inhibition Assay	48 h	IC50=14.4 ± 3.23 μM	24953027
REH		Growth Inhibition Assay	24 h	IC50=0.027 μM	25048236
REH		Growth Inhibition Assay	48 h	IC50=0.014 μM	25048236
REH		Growth Inhibition Assay	72 h	IC50=0.015 μM	25048236
RPMI-8226		Growth Inhibition Assay	24 h	IC50=106.6 μM	25048236
RPMI-8226		Growth Inhibition Assay	48 h	IC50=91.1 μM	25048236
RPMI-8226		Growth Inhibition Assay	72 h	IC50=14.9 μM	25048236
SCC25		Growth Inhibition Assay	24 h	IC50=43.3 ± 1.12 μM	25220729
SCC25		Growth Inhibition Assay	48 h	IC50=20.86 ± 1.07 μM	25220729
SCC25		Growth Inhibition Assay	72 h	IC50=8.41 ± 1.11 μM	25220729
SH-EP	20 μg/ml	Function Assay	24 h	increases the expression of endogenous DEPP	25261981
SH-SY5Y	0-10 μM	Growth Inhibition Assay	72 h	IC50=0.754 μM	25008900
SK-N-AS		Growth Inhibition Assay		IC50=0.24 ± 0.03 μM	25960282
SK-N-AS	0-10 μM	Growth Inhibition Assay	72 h	IC50=1.712 μM	25008900
SK-N-ASCis24		Growth Inhibition Assay		IC50=0.57 ± 0.11 μM	25960282
SK-N-DZ	0-10 μM	Growth Inhibition Assay	72 h	IC50=5.485 μM	25008900
SMMC-7721	40 μM	Function Assay	48 h	induces γH2AX foci formation	25544361
SW480	0.5-2.5 μM	Growth Inhibition Assay	48 h	IC50=4.92 ± 0.33 μM	25746763
T47D		Growth Inhibition Assay		IC50=3.18 ± 0.11 μM	25603122
T-47D		Growth Inhibition Assay	48 h	IC50=7.7 ± 0.7 μM	25216378
U-266		Growth Inhibition Assay	24 h	IC50=86.2 μM	25048236
U-266		Growth Inhibition Assay	48 h	IC50=68.4 μM	25048236
U-266		Growth Inhibition Assay	72 h	IC50=27.4 μM	25048236
U87	0-50 μM	Growth Inhibition Assay	48 h	decreases cell viability which can be enhanced by silibinin	25750273
UW228-3	0.01-300 μM	Growth Inhibition Assay	48 h	IC50=0.99 μM	25119185

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