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/ 拓扑异构酶 / Idarubicin HCl/盐酸伊达比星

Idarubicin HCl/盐酸伊达比星 {[allProObj[0].p_purity_real_show]}

货号：A131979 同义名： 伊达比星盐酸盐 / 4-Demethoxydaunorubicin hydrochloride; Idarubicin (hydrochloride)

Idarubicin HCl是伊达比星的盐酸盐形式，是一种蒽环类抗生素和DNA拓扑异构酶 II（topo II）抑制剂，对MCF-7细胞的IC50为3.3 ng/mL（在无细胞实验中）。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Idarubicin HCl/盐酸伊达比星 化学结构 CAS号：57852-57-0
Idarubicin HCl/盐酸伊达比星 化学结构
CAS号：57852-57-0
Idarubicin HCl/盐酸伊达比星 3D分子结构
CAS号：57852-57-0
Idarubicin HCl/盐酸伊达比星 化学结构 CAS号：57852-57-0
Idarubicin HCl/盐酸伊达比星 3D分子结构 CAS号：57852-57-0
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Idarubicin HCl/盐酸伊达比星 纯度/质量文件 产品仅供科研

货号：A131979 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Topo I ↓ Topo II ↓ Topo IV ↓ Topoisomerase ↓ 其他靶点 纯度
Ellagic acid ✔ 98%
β-Lapachone ✔ 99%+
(s)-10-hydroxycamptothecin ✔ 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

 		98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

 		98%
Topotecan ++++

Topo I (MCF-7 Luc cells), IC50: 13 nM

Topo I (DU-145 Luc cells), IC50: 2 nM

 		98%
Irinotecan HCl Trihydrate ✔ 98%
SN-38 ✔ 98%
Levofloxacin hydrate ✔ 98%
Dexrazoxane ✔ 99%+
Ofloxacin ✔ 98+%
Enoxacin ✔ 99%+
Flumequine +

Topo II, IC50: 15 μM

 		98%
Levofloxacin ✔ 97%
Etoposide ✔ 98%
Pefloxacin mesylate dihydrate ✔ 99.5%
Marbofloxacin ✔ 98+%
Voreloxin HCl ✔ 98%
Mitoxantrone 2HCl ✔ PKC 98%
Nalidixic acid ✔ 98%
Doxorubicin ✔ 97%
Novobiocin sodium ✔ 95%
Amonafide ✔ 99%+
Pirarubicin ✔ 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

 		99%+
Genistein ✔ EGFR 98%
Teniposide ✔ 98%
Moxifloxacin ✔ 98%
Ciprofloxacin ✔ 98%
Clinafloxacin ✔ 99%
Gatifloxacin ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Epirubicin HCl ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Idarubicin HCl/盐酸伊达比星 生物活性

靶点

  • Topo II

    Topo II (MCF-7 cells), IC50:3.3 ng/mL
描述 Idarubicin is a 4-demethoxy analog of the leukemia therapeutic daunorubicin, which intercalate in DNA and inhibit topoisomerase II, resulting in cancer cell cytotoxicity at lo concentration (IC50=20-120nM)[3]. Idarubicin has shown a greater cytotoxicity than daunorubicin or doxorubicin in various in vitro systems. This has been attributed to a better ability of idarubicin to induce the formation of topoisomerase II -mediated DNA breaks[4]. Idarubicin produces a concentration-dependent reduction in cell growth, with an IC50 value of approximately 0.01 μM. Idarubicin produced a concentration-dependent inhibition of DNA synthesis[5].

Idarubicin HCl/盐酸伊达比星 细胞研究

细胞系 浓度 检测类型 检测时间 活性说明 数据源
HepG2 cells Function assay Inhibition of liver stage Plasmodium berghei infection in HepG2 cells, IC50=6.62 μM 22586124
human ES2 cells Cytotoxic assay 24 h Cytotoxicity against human ES2 cells after 24 hrs by XTT assay, IC50=3.2 μM 24900668
human K562 cells Proliferation assay 72 h Antiproliferative activity against human K562 cells after 72 hrs, GI50=3.3 μM 25420175
human MCF7 cells Cytotoxic assay 24 h Cytotoxicity against human MCF7 cells after 24 hrs by XTT assay, IC50=7.3 μM 24900668

Idarubicin HCl/盐酸伊达比星 参考文献

[1]Orlandi P, Barbara C, et al. Idarubicin and idarubicinol effects on breast cancer multicellular spheroids. J Chemother. 2005 Dec;17(6):663-7.

[2]Colburn DE, Giles FJ, et al. In vitro evaluation of cytochrome P450-mediated drug interactions between cytarabine, idarubicin, itraconazole and caspofungin. Hematology. 2004 Jun;9(3):217-21.

[3]Dautant A, Langlois d'Estaintot B, Gallois B, Brown T, Hunter WN. A trigonal form of the idarubicin:d(CGATCG) complex; crystal and molecular structure at 2.0 A resolution. Nucleic Acids Res. 1995 May 25;23(10):1710-6.

[4]Robert J. Clinical pharmacokinetics of idarubicin [published correction appears in Clin Pharmacokinet 1993 Oct;25(4):350]. Clin Pharmacokinet. 1993;24(4):275-288.

[5]Gewirtz DA, Randolph JK, Chawla J, Orr MS, Fornari FA. Induction of DNA damage, inhibition of DNA synthesis and suppression of c-myc expression by the anthracycline analog, idarubicin (4-demethoxy-daunorubicin) in the MCF-7 breast tumor cell line. Cancer Chemother Pharmacol. 1998;41(5):361-369.

Idarubicin HCl/盐酸伊达比星 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.36mL

1.87mL

0.94mL

18.73mL

3.75mL

1.87mL

Idarubicin HCl/盐酸伊达比星 技术信息

CAS号57852-57-0
分子式C26H28ClNO9
分子量 533.95
SMILES Code O=C1C2=C(O)C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@](O)(C(C)=O)C4)=C4C(O)=C2C(C5=C1C=CC=C5)=O.[H]Cl
MDL No. MFCD00897212
别名 伊达比星盐酸盐 ;4-Demethoxydaunorubicin hydrochloride; Idarubicin (hydrochloride); NSC 256439; 4-DMD; 4-Demethoxydaunorubicin; 4-demethoxydaunorubicin HCl; Idarubicin hydrochloride
运输蓝冰
InChI Key JVHPTYWUBOQMBP-RVFAQHLVSA-N
Pubchem ID 636362
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, 2-8°C
溶解方案

DMSO: 85 mg/mL(159.19 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二

Tags: Idarubicin | 57852-57-0 | 4-Demethoxydaunorubicin | Topoisomerase | Topo II Inhibitor | Cell Cycle/DNA Damage | Anti-infection | Autophagy | Apoptosis | Topoisomerase | Bacterial | Fungal | Autophagy | Antibiotic | DNA/RNA Synthesis | c-Myc | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Idarubicin HCl/盐酸伊达比星 纯度/质量文件 | Idarubicin HCl/盐酸伊达比星 亚型比较 | Idarubicin HCl/盐酸伊达比星 生物活性 | Idarubicin HCl/盐酸伊达比星 细胞研究 | Idarubicin HCl/盐酸伊达比星 参考文献 | Idarubicin HCl/盐酸伊达比星 实验方案 | Idarubicin HCl/盐酸伊达比星 技术信息

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