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货号 产品名 纯度
A1229569 ATPase-IN-2

98%+
A987552 3′,4′,7-Trihydroxyflavone

7,3',4'-Trihydroxyflavone, a natural product isolated and purified from the seeds of Cassia occidentalis, can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclastogenesis via nuclear factor of activated T cells c1 (NFATc1).

95%
A348334 2,5-Di-tert-butylhydroquinone/2,5-二叔丁基对苯二酚

BHQ is a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).

98%
A1060682 EN6

EN6 是一种小分子自噬激活剂,共价靶向溶酶体 v-ATPase 的 ATP6V1A 亚基中的半胱氨酸 277,通过 Rag 鸟苷三磷酸酶激活机械靶 mTORC1。EN6 介导的 ATP6V1A 修饰使 v-ATPase 与 Rags 解耦,导致 mTORC1 信号抑制、溶酶体酸化增加和自噬激活。

99%+
A778809 Linaprazan/利那拉生

AZD0865 inhibits gastric H+,K+-ATPase by K+-competitive binding.

99%+
A1249487 KM91104

KM91104 is a specific v-ATPase inhibitor. It specifically targets the interaction between v-ATPase subunit a3 and subunit B2.

99%+
A370143 Thapsigargin/毒胡萝卜素

Thapsigargin is a naturally occurring tumor promoter derived from the plant Thapsia garganica. Potent inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Causes ER stress; can be used to induce autophagy in mammalian cells.

99%+
A388173 Esomeprazole

Esomeprazole is a proton-pump inhibitor which reduces stomach acid.

99%
A734422 BTB06584

BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase.

98%
A723745 Chebulinic acid/诃子林鞣酸

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.

99%+
A1176583 SCH28080

SCH 28080 is an inhibitor of H+, K+-ATPase with IC50 of 20 nM.

99%+
A684406 Diphyllin/二叶草素

Diphyllin, a natural arylnaphthalene, is potent inhibitor of vacuolar H(+)-ATPase (V-ATPase) that inhibits lysosomal acidification in osteoclasts.

99%+
A949923 Sodium orthovanadate/钒酸钠

Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.

99%
A587120 CDN1163

CDN1163 is an allosteric sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activator that improves Ca2+ homeostasis. CDN1163 attenuates diabetes and metabolic disorders.

99%+
A194814 FCCP/碳酰氰 4-(三氟甲氧基)苯腙

FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.

99%+
A611342 Blebbistatin

(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.

98%
A144214 Ciclopirox olamine/环吡酮胺

Ciclopirox Olamine is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses.

99%
A524606 Biacetyl monoxime/二乙酰一肟

Diacetyl Monoxime is an inhibitor of skeletal muscle myosin-II.

98%
A188600 Esomeprazole sodium/埃索美拉唑钠

Esomeprazole sodium, the sodium salt of esomeprazole which has the effect of reducing gastric acid secretion.

98%
A570627 Ilaprazole/艾普拉唑

Ilaprazole inhibited TOPK activities with high affinity and selectivity.

97%
产品名 ATPase 其他靶点 纯度
(-)-Blebbistatin 99%+
PF 03716556 ++++

H+/K+-ATPase, pIC50: ~6.5

99%+
Esomeprazole sodium 98%
BTB06584 98%
Ciclopirox 97%
CB-5083 ++++

p97 AAA ATPase, IC50: 11 nM

99%+
Ciclopirox olamine 99%
Brefeldin A +++

ATPase (HCT 116), IC50: 0.2 μM

99%+
Oligomycin A 99%
Sodium orthovanadate +++

(Na,K)-ATPase, IC50: 40 nM

99%
Golgicide A 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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