EN6 是一种小分子自噬激活剂，共价靶向溶酶体 v-ATPase 的 ATP6V1A 亚基中的半胱氨酸 277，通过 Rag 鸟苷三磷酸酶激活机械靶 mTORC1。EN6 介导的 ATP6V1A 修饰使 v-ATPase 与 Rags 解耦，导致 mTORC1 信号抑制、溶酶体酸化增加和自噬激活。

Thapsigargin是一种内质网 (ER) 应激诱导剂，是微粒体 Ca2+-ATP 酶的抑制剂。雷公藤甲素有效抑制多种细胞类型中冠状病毒 (HCoV-229E、MERS-CoV、SARS-CoV-2) 的复制。

CB-5083是一种首创的有效、选择性和口服可利用的p97 AAA ATPase/VCP抑制剂，通过其D2位点选择性抑制p97，IC50为11 nM。

7,3',4'-Trihydroxyflavone, a natural product isolated and purified from the seeds of Cassia occidentalis, can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclastogenesis via nuclear factor of activated T cells c1 (NFATc1).

BHQ is a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).

AZD0865 inhibits gastric H+,K+-ATPase by K+-competitive binding.

KM91104 is a specific v-ATPase inhibitor. It specifically targets the interaction between v-ATPase subunit a3 and subunit B2.

Esomeprazole is a proton-pump inhibitor which reduces stomach acid.

BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase.

SCH 28080 is an inhibitor of H+, K+-ATPase with IC50 of 20 nM.

Diphyllin, a natural arylnaphthalene, is potent inhibitor of vacuolar H(+)-ATPase (V-ATPase) that inhibits lysosomal acidification in osteoclasts.

Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.

CDN1163 is an allosteric sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activator that improves Ca2+ homeostasis. CDN1163 attenuates diabetes and metabolic disorders.

FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.

(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.

Ciclopirox Olamine is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses.

Diacetyl Monoxime is an inhibitor of skeletal muscle myosin-II.

Esomeprazole sodium, the sodium salt of esomeprazole which has the effect of reducing gastric acid secretion.

Ilaprazole inhibited TOPK activities with high affinity and selectivity.