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首页 / 抑制剂/激动剂 / 膜转运蛋白 / ATPase / Sodium orthovanadate/钒酸钠

Sodium orthovanadate/钒酸钠 {[allProObj[0].p_purity_real_show]}

货号：A949923 同义名： 正钒酸钠 / NSC 79534

Sodium orthovanadate是一种碱性磷酸酶和（Na,K）-ATP 酶抑制剂，IC50 为 10 μM。

Sodium orthovanadate/钒酸钠 化学结构 CAS号：13721-39-6
Sodium orthovanadate/钒酸钠 化学结构
CAS号：13721-39-6
Sodium orthovanadate/钒酸钠 3D分子结构
CAS号：13721-39-6
Sodium orthovanadate/钒酸钠 化学结构 CAS号：13721-39-6
Sodium orthovanadate/钒酸钠 3D分子结构 CAS号：13721-39-6
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Sodium orthovanadate/钒酸钠 纯度/质量文件 产品仅供科研

货号：A949923 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

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产品名称 ATPase ↓ 其他靶点 纯度
(-)-Blebbistatin 99%+
PF 03716556 ++++

H+/K+-ATPase, pIC50: ~6.5

 		99%
Esomeprazole sodium ✔ 98%
BTB06584 ✔ 99%
Ciclopirox ✔ 97%
CB-5083 ++++

p97 AAA ATPase, IC50: 11 nM

 		99%+
Ciclopirox olamine ✔ 99%
Brefeldin A +++

ATPase (HCT 116), IC50: 0.2 μM

 		99%+
Oligomycin A ✔ 99%
Sodium orthovanadate +++

(Na,K)-ATPase, IC50: 40 nM

 		25-28%V
Golgicide A ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Sodium orthovanadate/钒酸钠 生物活性

靶点

  • ATPase

    (Na,K)-ATPase, IC50:40 nM
描述 Sodium orthovanadate (SOV) is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue[3]. The decreased tyrosine phosphorylation of PTEN and the decreased serine phosphorylation of Akt induced by ischemia were suppressed by SOV, respectively. SOV could alter the phosphorylation status of ASK1 at serine 83 and threonine 845 induced by ischemia[4]. SOV changed SFA (saturated fatty acids) and MUFA (monounsaturated fatty acids) composition in THP-1 macrophages and increased expression of SCD (stearoyl-coenzyme A desaturase). Sodium orthovanadate did not affect the amount of any PUFA[5]. SOV is able to overcome sorafenib resistance and strengthens sorafenib in suppressing sorafenib-resistant HCC (hepatocellular carcinoma) cells in vitro and in animal models. Similar to its action on parental HCC cells, SOV induced cell cycle arrest at G2/M phases by regulating cyclin B1 and cyclin-dependent kinase 1, and apoptosis by reducing mitochondrial membrane potential, in sorafenib-resistant HCC cells[6].

Sodium orthovanadate/钒酸钠 细胞实验

Cell Line
Concentration Treated Time Description References
HepG2-SR cells 5 µM 24 hours SOV significantly reduced intracellular K+ content and decreased ATPase activity. Sci Rep. 2018 Jun 26;8(1):9706.
Huh7-SR cells 10 µM 24 hours SOV significantly reduced the expression of HIF-1α and HIF-2α and inhibited their nuclear translocation. Sci Rep. 2018 Jun 26;8(1):9706.
Leishmania major promastigotes 0–250 µM 48 hours To assess the sensitivity of Leishmania major to phosphatase inhibitors with SPP overexpression or half knockout. The results showed that SPP-overexpressing parasites were more sensitive to the growth inhibition by sodium orthovanadate. Sci Rep. 2022 Sep 26;12(1):16064.

Sodium orthovanadate/钒酸钠 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c-nu/nu mice Subcutaneous Huh7-SR cell tumor model Intraperitoneal injection 15 mg/kg Once daily for 20 days SOV significantly suppressed tumor growth and enhanced the anti-tumor effect of sorafenib. Sci Rep. 2018 Jun 26;8(1):9706.

Sodium orthovanadate/钒酸钠 参考文献

[1]Wu Y, Ou-Yang JP, et al. Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B. Acta Pharmacol Sin. 2005 Mar;26(3):345-52.

[2]Cantley LC Jr, Josephson L, et al. Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. J Biol Chem. 1977 Nov 10;252(21):7421-3.

[3]Gordon JA. Use of vanadate as protein-phosphotyrosine phosphatase inhibitor. Methods Enzymol. 1991;201:477-82

[4]Wu DN, Pei DS, Wang Q, Zhang GY. Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rat hippocampus. Neurosci Lett. 2006 Aug 14;404(1-2):98-102

[5]Korbecki J, Gutowska I, Wiercioch M, Łukomska A, Tarnowski M, Drozd A, Barczak K, Chlubek D, Baranowska-Bosiacka I. Sodium Orthovanadate Changes Fatty Acid Composition and Increased Expression of Stearoyl-Coenzyme A Desaturase in THP-1 Macrophages. Biol Trace Elem Res. 2020 Jan;193(1):152-161

[6]Jiang W, Li G, Li W, Wang P, Xiu P, Jiang X, Liu B, Sun X, Jiang H. Sodium orthovanadate overcomes sorafenib resistance of hepatocellular carcinoma cells by inhibiting Na+/K+-ATPase activity and hypoxia-inducible pathways. Sci Rep. 2018 Jun 26;8(1):9706

Sodium orthovanadate/钒酸钠 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.44mL

1.09mL

0.54mL

27.19mL

5.44mL

2.72mL

54.37mL

10.87mL

5.44mL

Sodium orthovanadate/钒酸钠 技术信息

CAS号13721-39-6
分子式Na3O4V
分子量 183.91
SMILES Code O=[V]([O-])([O-])[O-].[Na+].[Na+].[Na+]
MDL No. MFCD00003511
别名 正钒酸钠 ;NSC 79534
运输蓝冰
InChI Key IHIXIJGXTJIKRB-UHFFFAOYSA-N
Pubchem ID 61671
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, room temperature
溶解方案

H2O: 8 mg/mL(43.5 mM)，配合低频超声助溶

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Sodium orthovanadate | NSC 79534 | 正钒酸钠 | ATPase | AmBeed-信号通路专用抑制剂 | Sodium orthovanadate/钒酸钠 纯度/质量文件 | Sodium orthovanadate/钒酸钠 亚型比较 | Sodium orthovanadate/钒酸钠 生物活性 | Sodium orthovanadate/钒酸钠 参考文献 | Sodium orthovanadate/钒酸钠 实验方案 | Sodium orthovanadate/钒酸钠 技术信息

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