There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase.
BTB06584 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HL-1 cells
100 µM
15 minutes
Evaluate the effect of BTB on mitochondrial membrane potential, results showed BTB significantly reduced ΔΨm under respiratory inhibition
Br J Pharmacol. 2014 Sep;171(18):4193-206.
MH22a cells
28.0 µM (GI50)
24 hours
Evaluation of BTB06584 cytotoxicity in MH22a cells, showing lower cytotoxicity than expected
Int J Mol Sci. 2023 Aug 5;24(15):12460.
Mouse chondrocytes
2.5 µM
48 hours
BTB06584 ameliorates early phenotype loss by inhibiting ATP hydrolysis activity of F1Fo-ATPase, reducing proton backflow and ROS production, and regulating the MAPK pathway.
Bone Res. 2022 Apr 27;10(1):38.
HCT-116 cells
80.0 µM (GI50 )
48 hours
Evaluation of BTB06584 growth inhibition in HCT-116 cells, showing lower cytotoxicity than expected
Int J Mol Sci. 2023 Aug 5;24(15):12460.
HeLa cells
100 µM
80 minutes
Evaluate the effect of BTB on ATP consumption, results showed BTB significantly slowed ATP consumption
Br J Pharmacol. 2014 Sep;171(18):4193-206.
BTB06584 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Acute lung inflammation model
Intraperitoneal injection
1 mg/kg
Single dose, pre-treatment 30 minutes before exposure
BTB06584 protects against cell death, induces robust lung neutrophil recruitment but does not induce massive eosinophil or neutrophil peroxidase release when compared to vehicle treated group.
Front Immunol. 2023 Mar 13;14:1126574
Zebrafish
Pinotage zebrafish mutants
Aqueous solution
1 μM
24 hours
Evaluate the rescue effect of BTB on hemoglobin synthesis, results showed BTB significantly increased hemoglobin synthesis
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