To evaluate the ability of pefloxacin disk diffusion method to detect fluoroquinolone-resistant Salmonella enterica. Results showed that the 5 μg pefloxacin disk correctly identified all resistant isolates.
J Clin Microbiol. 2015 Nov;53(11):3411-7
Xenopus oocytes expressing human α4β2 nAChRs
100 µM
30 s preapplication + 5 s coapplication
To investigate the inhibitory effects of Pefloxacin on two stoichiometries of α4β2 nAChRs. Results showed that Pefloxacin significantly inhibited (α4)2(β2)3 nAChRs (inhibition of 73.3 ± 1.9%) but had no significant effect on (α4)3(β2)2 nAChRs.
ACS Chem Neurosci. 2022 Jun 15;13(12):1805-1817
Pefloxacin mesylate dihydrate/甲磺酸培氟沙星二水合物 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Sprague-Dawley rats
Male Sprague-Dawley rats
Intravenous injection
10 mg/kg
Single dose
To investigate the pharmacokinetics of pefloxacin and its interaction with cyclosporin A in rat blood, brain, and bile. Results showed that pefloxacin could penetrate the blood-brain barrier, and the concentration in bile was higher than in blood, suggesting active biliary excretion of pefloxacin. Cyclosporin A had no significant impact on the pharmacokinetics of pefloxacin in rat blood and brain.
Br J Pharmacol. 2001 Mar;132(6):1310-6
Mice
Normal mice
Oral
400 mg/kg
Single dose
Measure proteoglycan synthesis, observed early inhibition followed by a repair-like response
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